The mineralization, drug release and <i>in vivo</i> bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds

Zhou, Rong; Ni, Haijian; Peng, Jie; Liu, Ning; Chen, Shu; Shao, Jiahua; Fu, Qiwei; Liu, Junjian; Chen, Feng; Qian, Qirong

doi:10.1039/c9ra09385k

Cited by 11 publications

(14 citation statements)

References 47 publications

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“…Similar findings were reported by Fu et al [ 74 ] and Zhou et al [ 75 ], who obtained ACP-contained polylactic acid nanofibers or modified tantalum scaffolds for bone regeneration, respectively. In both cases, the plate-like particles of hydroxyapatite after immersion in SBF were formed on investigated composites, providing osteoconductive properties in vitro and in vivo.…”

Section: Resultssupporting

confidence: 90%

Microwave-Assisted Fabrication of Mesoporous Silica-Calcium Phosphate Composites for Dental Application

et al. 2020

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Herein, the microwave-assisted wet precipitation method was used to obtain materials consisting of mesoporous silica (SBA-15) and calcium orthophosphates (CaP). Composites were prepared through immersion of mesoporous silica in different calcification coating solutions and then exposed to microwave radiation. The composites were characterized in terms of molecular structure, crystallinity, morphology, chemical composition, and mineralization potential by Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), and scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM-EDX). The application of microwave irradiation resulted in the formation of different types of calcium orthophosphates such as calcium deficient hydroxyapatite (CDHA), octacalcium phosphate (OCP), and amorphous calcium phosphate (ACP) on the SBA-15 surface, depending on the type of coating solution. The composites for which the progressive formation of hydroxyapatite during incubation in simulated body fluid was observed were further used in the production of final pharmaceutical forms: membranes, granules, and pellets. All of the obtained pharmaceutical forms preserved mineralization properties.

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Section: Resultssupporting

confidence: 90%

Microwave-Assisted Fabrication of Mesoporous Silica-Calcium Phosphate Composites for Dental Application

et al. 2020

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“…Simultaneously, the hydrophilicity of two structures was also significantly improved due to the capillary effects. The ACP nanospheres were observed to transform into HA nanosheets in a rapid pace after soaked in SBF, and this transformation promised rapid mineralization, improved wettability and fast protein release rate [190,191]. In vivo, both the two kinds of modified porous Ta scaffolds repaired the subchondral bone defects with substantial new bone formation, indicating a promising clinical prospect for bone defect restoration.…”

Section: Cytotoxicity (Mc3t3-e1 Cells) •mentioning

confidence: 99%

“…Similarly, the zoledronic acid-HA coated porous Ta rod also gained significantly more bone formation both at peri-implant area and within the inner space compared with the unmodified porous Ta groups in canine models [188]. Zhou et al introduced amorphous calcium phosphate (ACP) nanospheres and HA nanorods coating to modify porous Ta [190]. When immersed in SBF, the two nanostructures showed rapid mineralization on their surface and the mineral deposition increasingly accumulated within 1 week.…”

Section: Cytotoxicity (Mc3t3-e1 Cells) •mentioning

confidence: 99%

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

Huang¹,

Pan²,

Qiu³

2021

Preprint

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Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone-implant stability in long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, low elastic modulus and high friction coefficient of porous Ta can effectively avoid stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta based implants or prostheses are mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta based implants or prostheses have shown their clinical value in the treatment of individual patient who need specially designed implant or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.

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“…By contrast, new bone tissues were lacking in the unmodified samples. [192] CaP nanospheres-PLA coating…”

mentioning

confidence: 99%

“…Amorphous calcium phosphate (ACP) nanospheres and HA nanorods coating on the surface of Ta scaffold (a). Reprinted from ref [192]…”

mentioning

confidence: 99%

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

2021

View full text Add to dashboard Cite

Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone–implant stability in the long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, the low elastic modulus and high friction coefficient of porous Ta allow it to effectively avoid the stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta-based implants or prostheses is mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta-based implants or prostheses have shown their clinical value in the treatment of individual patients who need specially designed implants or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.

show abstract

The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds

Cited by 11 publications

References 47 publications

Microwave-Assisted Fabrication of Mesoporous Silica-Calcium Phosphate Composites for Dental Application

Microwave-Assisted Fabrication of Mesoporous Silica-Calcium Phosphate Composites for Dental Application

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

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