The mitochondria in human normal and cholestatic liver

Ekholm, R.; Edlund, Y

doi:10.1007/978-3-642-49764-3_60

Cited by 11 publications

(5 citation statements)

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“…In several cases the mitochondria contain striped regions (figs. lB, 2 and 3) resembling those described in other con-nections by Jezequel (2) and Ekholm and Edlund (1).…”

Section: Discussionsupporting

confidence: 83%

Electron Microscopic Study of Liver Mitochondria from Human Alcoholics

Kiessling

Lindgren

Strandberg

et al. 1964

Journal of Internal Medicine

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“…In several cases the mitochondria contain striped regions (figs. lB, 2 and 3) resembling those described in other con-nections by Jezequel (2) and Ekholm and Edlund (1).…”

Section: Discussionsupporting

confidence: 83%

Electron Microscopic Study of Liver Mitochondria from Human Alcoholics

Kiessling

Lindgren

Strandberg

et al. 1964

Journal of Internal Medicine

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Section: Introductionmentioning

confidence: 75%

“…To the best of our knowledge, the first description of giant mitochondria in liver parenchymal cells were reported by Ekholm and Edlund in 1960 in patients diagnosed with cholestatic liver disease. 8 In this TEM study, the authors described enlarged mitochondria that harbour inclusions of a 'crystalloid' nature. The authors put forward that the occurrence of giant mitochondria is the result of differences in the biochemical pathways between normal versus cholestatic livers.…”

Section: Introductionmentioning

confidence: 98%

Giant mitochondria in human liver disease

Shami,

Samarska,

Koek

et al. 2023

Liver International

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This thematic review aims to provide an overview of the current state of knowledge about the occurrence of giant mitochondria or megamitochondria in liver parenchymal cells. Their presence and accumulation are considered to be a major pathological hallmark of the health and fate of liver parenchymal cells that leads to overall tissue deterioration and eventually results in organ failure. The first description on giant mitochondria dates back to the 1960s, coinciding with the availability of the first generation of electron microscopes in clinical diagnostic laboratories. Detailed accounts on their ultrastructure have mostly been described in patients suffering from alcoholic liver disease, chronic hepatitis, hepatocellular carcinoma and non‐alcoholic fatty liver disease. Interestingly, from this extensive literature survey, it became apparent that giant mitochondria or megamitochondria present themselves with or without highly organised crystal‐like intramitochondrial inclusions. The origin, formation and potential role of giant mitochondria remain to‐date largely unanswered. Likewise, the biochemical composition of the well‐organised crystal‐like inclusions and their possible impact on mitochondrial function is unclear. Herein, concepts about the possible mechanism of their formation and three‐dimensional architecture will be approached. We will furthermore discuss their importance in diagnostics, including future research outlooks and potential therapeutic interventions to cure liver disease where giant mitochondria are implemented.

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“…In addition to the three types of IMFB, electronopaque round masses measuring up to 150 m~ in diameter were located in the matrix of the mitochondria and readily distinguished from the regular mitochondrial granules (Figs. 7,9,10). These usually occurred in relationship to type III IMFB and less frequently in relationship to types I and II.…”

mentioning

confidence: 99%

Intramitochondrial Filamentous Bodies in the Thick Limb of Henle of the Rat Kidney

Suzuki

Mostofi

1967

The Journal of Cell Biology

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"Intramitochondrial filamentous bodies" (IMFB) were occasionally found within the matrix of some mitochondria of the thick limb of Hcnle of the rat kidney, but not clsewhere in thc tubular system. Three types wcre recognized: type I, an accumulation of filaments 55 A thick; type II, a bundle of parallel filaments having the same thickness as those of typc I and rcgular spacing, 87 A apart, from center to center; and type III, consisting of type II with regular light bands of 280 A periodicity and a helical border of prismatic tubular cristae. In addition to these, clectron-opaque masses showing variable and faint substructures wcre found in the matrix of mitochondria. It is suggested that all these IMFB may originate from mitochondrial cristae and that type II IMFB may be an intermediate developmental form between type I and type III. After uranyl acetate staining, IMFB and the membranes of prismatic tubular cristae showed highly increased electron opacity. The literature has been reviewed for reports of intramitochondrial filamentous inclusions in various types of cells. These inclusions have been classified according to their structural characteristics and the localization in the mitochondria and compared with IMFB reported herein.

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The mitochondria in human normal and cholestatic liver

Cited by 11 publications

References 0 publications

Electron Microscopic Study of Liver Mitochondria from Human Alcoholics

Electron Microscopic Study of Liver Mitochondria from Human Alcoholics

Giant mitochondria in human liver disease

Intramitochondrial Filamentous Bodies in the Thick Limb of Henle of the Rat Kidney

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