The mixture toxicity of heavy metals on Photobacterium phosphoreum and its modeling by ion characteristics-based QSAR

Zeng, Jianbin; Chen, Fen; Li, Mi; Wu, Ligui; Zhang, Huan; Zou, Xiaoming

doi:10.1371/journal.pone.0226541

Cited by 16 publications

(8 citation statements)

References 43 publications

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“…However, this study did not examine if this response was due to synergistic or additive interactive effects of the metals in the mixture. In prokaryotic systems, the limited studies on this form of stress have exclusively focused on determinations of IC 50 values for binary combinations of metals [18][19][20][21][22][23][24]. For example, Fulladosa et al [18] explored the synergistic/ antagonistic toxicity of binary metal pairings in Vibrio fisheri by determining IC 50 values for individual metals and binary combinations of metals.…”

Section: Introductionmentioning

confidence: 99%

Mixed heavy metal stress induces global iron starvation response

et al. 2022

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Multiple heavy metal contamination is an increasingly common global problem. Heavy metals have the potential to disrupt microbially mediated biogeochemical cycling. However, systems-level studies on the effects of combinations of heavy metals on bacteria are lacking. For this study, we focused on the Oak Ridge Reservation (ORR; Oak Ridge, TN, USA) subsurface which is contaminated with several heavy metals and high concentrations of nitrate. Using a native Bacillus cereus isolate that represents a dominant species at this site, we assessed the combined impact of eight metal contaminants, all at site-relevant concentrations, on cell processes through an integrated multi-omics approach that included discovery proteomics, targeted metabolomics, and targeted gene-expression profiling. The combination of eight metals impacted cell physiology in a manner that could not have been predicted from summing phenotypic responses to the individual metals. Exposure to the metal mixture elicited a global iron starvation response not observed during individual metal exposures. This disruption of iron homeostasis resulted in decreased activity of the iron-cofactor-containing nitrate and nitrite reductases, both of which are important in biological nitrate removal at the site. We propose that the combinatorial effects of simultaneous exposure to multiple heavy metals is an underappreciated yet significant form of cell stress in the environment with the potential to disrupt global nutrient cycles and to impede bioremediation efforts at mixed waste sites. Our work underscores the need to shift from single- to multi-metal studies for assessing and predicting the impacts of complex contaminants on microbial systems.

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Section: Introductionmentioning

confidence: 99%

Mixed heavy metal stress induces global iron starvation response

et al. 2022

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“…This revealed additive, synergistic, and antagonistic effects based on ionization potential, the first hydrolysis constant, and formation constant value. 194 In another study, such a model also characterized binding…”

Section: In Silico and Computational Modelsmentioning

confidence: 99%

Heavy Metal Exposure and Cardiovascular Disease

Pan,

Gong,

Liang

2024

Circulation Research

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Heavy metals are harmful environmental pollutants that have attracted widespread attention due to their health hazards to human cardiovascular disease. Heavy metals, including lead, cadmium, mercury, arsenic, and chromium, are found in various sources such as air, water, soil, food, and industrial products. Recent research strongly suggests a connection between cardiovascular disease and exposure to toxic heavy metals. Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of reactive oxygen species, which can then exacerbate reactive oxygen species generation and induce inflammation, resulting in endothelial dysfunction, lipid metabolism distribution, disruption of ion homeostasis, and epigenetic changes. Over time, heavy metal exposure eventually results in an increased risk of hypertension, arrhythmia, and atherosclerosis. Strengthening public health prevention and the application of chelation or antioxidants, such as vitamins and beta-carotene, along with minerals, such as selenium and zinc, can diminish the burden of cardiovascular disease attributable to metal exposure.

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“…Giovanella et al applied V. fischeri to analyze the biotoxicity of diesel‐contaminated soil [58]. Zeng et al experimented to assess the inhibitory toxicity of five heavy metals (Cu 2+ , Co 2+ , Zn 2+ , Fe 3+ , and Cr 3+ ), as well as their binary mixtures, against P. phosphoreum T3 [59]. In addition, Wanjari et al successfully isolated Vibrio harveyi and Vibrio natriegens from seawater samples.…”

Section: Development Of Luminescent Bacteria–based Biosensorsmentioning

confidence: 99%

Recent advances in the development and applications of luminescent bacteria–based biosensors

Li,

Zhao,

et al. 2024

Luminescence

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Luminescent bacteria–based biosensors are widely used for fast and sensitive monitoring of food safety, water quality, and other environmental pollutions. Recent advancements in biomedical engineering technology have led to improved portability, integration, and intelligence of these biotoxicity assays. Moreover, genetic engineering has played a significant role in the development of recombinant luminescent bacterial biosensors, enhancing both detection accuracy and sensitivity. This review provides an overview of recent advances in the development and applications of novel luminescent bacteria–based biosensors, and future perspectives and challenges in the cutting‐edge research, market translation, and practical applications of luminescent bacterial biosensing are discussed.

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The mixture toxicity of heavy metals on Photobacterium phosphoreum and its modeling by ion characteristics-based QSAR

Cited by 16 publications

References 43 publications

Mixed heavy metal stress induces global iron starvation response

Mixed heavy metal stress induces global iron starvation response

Heavy Metal Exposure and Cardiovascular Disease

Recent advances in the development and applications of luminescent bacteria–based biosensors

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