The Mode of Action of Diuretics

Lohrmann, E.; Nitschke, Roland; Burhoff, I.; Masereel, Bernard; Pirotte, Bernard; Schlatter, Eberhard; Delarge, J.; Lang, Hans‐Jochen; Englert, Heinrich C.; Salomonsson, Max; Persson, A. Erik G.; Eidelman, Ofer; Cabantchik, Z. I.; Greger, R.

doi:10.1007/978-3-662-35158-1_107

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1991

1995

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Cited by 4 publications

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“…These substances interact in their anionic form with the luminal side of the Naf-K+-2C1-cotransporter through an ionic bound at a C1-binding site (34,41,51). At higher concentrations, torasemide blocks the basolateral C1-channel of the same nephron segment (24).…”

Section: Introductionmentioning

confidence: 98%

“…The cotransport system of the Henle's loop is the target for other high ceiling diuretics, such as furosemide, bumetanide, or piretanide (39,72). These substances interact in their anionic form with the luminal side of the Naf-K+-2C1-cotransporter through an ionic bound at a C1-binding site (34,41,51). At higher concentrations, torasemide blocks the basolateral C1-channel of the same nephron segment (24).…”

Section: Introductionmentioning

confidence: 99%

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