The Modulatory Role of Artichoke leaves Water Extract on Lipid Status on Rats Fed High Fat Diet

Abstract

High fat diet HFD induces excessive body fat content and lipid abnormalities. The importance of using medicinal plants becomes more patent in the present time Artichoke is a plant that traditionally used for treatment of different disease. The study aimed to investigate the role of supplementing low or high doses of water extract of artichoke leaves in rats fed HFD. For this purpose, four rat groups were established as follow: control group, high fat diet group, Low dose artichoke+ HFD group treated by low dose of artichoke extract(600 mg /kg b.w/day) after three weeks following obesity induction, and high dose artichoke +HFD rats was treated by high dose of artichoke extract(1500 mg /kg b.w /day). Body weight gain, serum lipid parameters, liver enzymes and liver histological status were examined. Results showed that HFD increased body weight, lipid parameters and causes abnormal liver enzyme levels along with fat droplets accumulation between liver cells. These parameters were counteracted by supplementing either low or high dose of artichoke extract, indicating the mitigating effect of artichoke against HFD side effects. It was noticed that the hypolipodemic and antiatherogenic effect was more observable in low dose of extract than that of high dose.

Hepatoprotective effect of Artichoke (Cynara scolymus) in laying hens

“…This finding was similar to the study carried out by Salem et al, (2017). Smilarly Abdulkhaleq et al, (2019) examined the effect of using low and high doses of water extract of artichoke leaves that given to 5255 rats observed a significant reduction in serum MDA level, and increased GSH level. Also Kaymaz et al (2017) reported that supplementation with aqueous extract of artichoke leaf of rat diet caused significant decrease of MDA level and significant increase of activity of SOD, GPx, and CAT in treatment group compared with control group.…”

“…Consistent with our findings, Yıldız et al, (2008) reported that artichoke decreased serum triglyceride levels in laying hens. Smilarly, Abdulkhaleq et al, (2019) found that artichoke extract treatment decreased the triglyceride level when compared to HFD (high feed diet) group. Suarez et al, (2019) reported that high-fat diets supplemented with 20% of artichoke significantly reduced plasma triglyceride levels (34%), plasma LDL and VLDL (29%) and total (24%) cholesterol.…”