The Mothers and Children’s Environmental Health (MOCEH) study

Kim, Byungmi; Ha, Mina; Park, Hyesook; Lee, Bo Eun; Kim, Young Ju; Hong, Yun–Chul; Kim, Yangho; Chang, Namsoo; Roh, Yun Ho; Kim, Boong-Nnyun; Oh, Se‐Young; Ha, Eun–Hee

doi:10.1007/s10654-009-9370-7

Cited by 110 publications

(63 citation statements)

References 40 publications

(24 reference statements)

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“…Comprehensive information about the study is available elsewhere (Kim et al, 2009). The study sample comprised pregnant women at mid-pregnancy (for example, 12-28 weeks of gestation) of a normal (not-at-risk) pregnancy who were willing to participate after receiving written information about the study.…”

Section: Subject and Methodsmentioning

confidence: 99%

Association of maternal folate nutrition and serum C-reactive protein concentrations with gestational age at delivery

Kim

Hwang

et al. 2010

Eur J Clin Nutr

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Background/objectives: C-reactive protein (CRP) is the most extensively studied inflammatory risk marker, and elevated serum CRP concentrations in pregnant women are known to be associated with subsequent development of preeclampsia and preterm delivery. Researchers have suggested that folate intake may help to control the inflammation process. We examined whether folate nutrition modifies the relationship between serum CRP concentration and gestational age at delivery. Subjects/methods: Serum CRP concentrations were analyzed in 815 pregnant women between 12 and 28 weeks of gestation. Dietary intakes were assessed using a 24-h dietary recall. The serum folate and high-sensitivity CRP concentrations were analyzed by radioassay and latex agglutination tests, respectively. Results: Serum CRP concentration was negatively correlated (Po0.001) with gestational age at delivery. Serum folate concentration was negatively correlated (Po0.01) with serum CRP concentration, and total dietary folate intake was positively correlated (Po0.001) with serum folate concentration. Multiple regression analysis after adjustment for covariates revealed that maternal CRP concentrations were negatively associated with gestational age at delivery; these negative associations existed only when folate intake during pregnancy was below the Korean estimated average requirements (520 mg dietary folate equivalent per day), and serum folate concentrations were above the normal (6 ng/ml). Conclusions: We found that adequate maternal folate intake during pregnancy may have a beneficial role against shorter gestational age at delivery, which is associated with higher serum CRP concentrations in pregnant women.

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Section: Subject and Methodsmentioning

confidence: 99%

Association of maternal folate nutrition and serum C-reactive protein concentrations with gestational age at delivery

Kim

Hwang

et al. 2010

Eur J Clin Nutr

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“…New methods for contacting participants, which have been used in other more recently started studies, including use of internet, sms and e-mail, are currently being explored [92, [252][253][254][255][256][257][258][259][260][261][262].…”

Section: Follow Up and Retention Strategiesmentioning

confidence: 99%

The Generation R Study: design and cohort update 2012

et al. 2012

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The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on four primary areas of research: (1) growth and physical development; (2) behavioural and cognitive development; (3) diseases in childhood; and (4) health and healthcare for pregnant women and children. In total, 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. General follow-up rates until the age of 4 years exceed 75%. Data collection in mothers, fathers and preschool children included questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome wide association screen is available in the participating children. Regular detailed hands on assessment are performed from the age of 5 years onwards. Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.

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“…Details of the methods of the MOCEH study with specific eligibility criteria for the participation of mothers have been published earlier (32) . The study sample comprised pregnant women at mid-pregnancy (i.e.…”

Section: Study Populationmentioning

confidence: 99%

Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea

Lamichhane¹,

Leem²,

Kim³

et al. 2016

Public Health Nutr.

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Objective: Polycyclic aromatic hydrocarbons (PAH) are common dietary exposures that cross the human placenta and are classified as a probable human carcinogen. The aim of the present study was to investigate the potential impact of exposure to PAH-containing meat consumed during pregnancy on birth outcomes. Design: Prospective birth cohort study. Only non-smoking women with singleton pregnancies, who were free from chronic disease such as diabetes and hypertension, were included in the study. Maternal consumption of PAH-rich meat was estimated through FFQ. Multiple linear regression was used to assess factors related to higher intake and the association between dietary PAH and birth outcomes.

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The Mothers and Children’s Environmental Health (MOCEH) study

Cited by 110 publications

References 40 publications

Association of maternal folate nutrition and serum C-reactive protein concentrations with gestational age at delivery

Association of maternal folate nutrition and serum C-reactive protein concentrations with gestational age at delivery

The Generation R Study: design and cohort update 2012

Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea

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