The multicenter observational non-interventional study of combination anti-tuberculosis drugs used in treatment of pulmonary tuberculosis patients

Тюлькова, Т. Е.; Мохирева, Л. В.; Старшинова, Анна; Яблонский, П. К.; Ахильгова, Л. И.; Баронова, О. Д.; Громов, А. В.; Отпущеникова, О. Н.; Оганезова, Г. С.; Левченко, М. В.; Panova, I. A.; Трушина, О. А.; Ясинецкая, Н. В.; Сахаритова, Е А

doi:10.21292/2075-1230-2020-98-8-46-56

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…The destruction of MBT occurs faster, and the likelihood of drug resistance formation decreases (Faust et al 2019). A recent Russian multicenter observational study demonstrated that the use of fixed-dose combined anti-TB drugs in patients with newly diagnosed tuberculosis or its recurrence with preserved MBT sensitivity to Isoniazid and Rifampicin in chemotherapy regimens I and III was effective and was characterized by sufficient safety and tolerability (Tyulkova et al 2020).…”

Section: Stages and Regimens To Treat Tuberculosismentioning

confidence: 99%

Modern approaches to pharmacotherapy of tuberculosis infection in children

Новиков¹,

Usacheva²,

Myakisheva³

2021

RRP

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Anti-TB drugs for children: Aetiotropic therapy is used for the treatment of tuberculosis (TB) in children, as well as in adult patients. Anti-tuberculosis drugs (anti-TB drugs) are divided into 3 lines, taking into account drug sensitivity in Mycobacterium tuberculosis (MBT). First-line anti-TB drugs (basic) are used to treat TB caused by drug-susceptible MBT. Second- and third-line (reserve) drugs are recommended for the treatment of MBT-induced multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB, respectively. Stages and regimens to treat tuberculosis: Chemotherapy of tuberculosis in children is carried out in 2 stages (intensive treatment and continuation of treatment) and includes 5 regimens. Each regimen assumes a certain combination of anti-TB drugs, indicating the duration and frequency of their administration. The final chemotherapy regimen is chosen only according to the results of determining the drug sensitivity. To improve the TB epidemic among children, it is important to improve the regimens for the use of anti-TB drugs. The effectiveness of anti-tuberculosis pharmacotherapy is largely determined by the MBT sensitivity and the rational choice of the chemotherapy regimen. The wrong choice of a chemotherapy regimen or its violation threatens to reduce the effectiveness of pharmacotherapy and expand the spectrum of resistance of the pathogen. The development of fixed-dose combination anti-TB drugs and special dosage forms for children will improve the quality of chemotherapy and adherence to treatment. Pharmacoeconomic studies are needed to increase the effectiveness of drug pharmacotherapy for tuberculosis infection in children and to optimize the costs of its implementation.

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Section: Stages and Regimens To Treat Tuberculosismentioning

confidence: 99%

Modern approaches to pharmacotherapy of tuberculosis infection in children

Новиков¹,

Usacheva²,

Myakisheva³

2021

RRP

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Experience of Fixed-Dose Combinations of Anti-Tuberculosis Drugs for Preventive Treatment in Children

Baronova,

Aksenova,

Klevno

et al. 2023

Tuberk. bolezni lëgk.

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The objective: to evaluate the effectiveness and safety of preventive treatment with fixed-dose combination of anti-tuberculosis drugs (FDCs) in children from groups at high risk of developing tuberculosis.Subjects and Methods. Effectiveness of preventive treatment was analyzed in 318 children from groups at high risk of developing tuberculosis. Also, we studied the possibility of successful completion of the full course of treatment using FDCs and preventive treatment regimens containing at least two single drugs. Inclusion criteria were as follows: the child at high risk of developing tuberculosis; no clinical and radiological signs of active tuberculosis; lack of information about the resistance to first-line drugs at the suspected source of infection; and negative HIV status. A group of children (172 people) underwent preventive treatment using FDCs, of them 126 patients received FDCs containing isoniazid 150 mg + pyrazinamide 500 mg + pyridoxine hydrochloride 15 mg, and 46 patients received FDCs containing isoniazid 150 mg + ethambutol 400 mg + pyridoxine hydrochloride 15 mg. The comparison group (CG) included 146 children who received preventive treatment with single drugs: 111 children received isoniazid and pyrazinamide, and 35 children received isoniazid and ethambutol.Results. When assessing the safety and effectiveness, no statistically significant differences were found when using FDCs and single-drug regimens. 91.9% of children receiving FDCs and 86.3% of children receiving single-drug regimens successfully completed the full course of treatment. When taking FDCs, there was a tendency to lower incidence of adverse events. With the FDC (isoniazid 150 mg + pyrazinamide 500 mg + pyridoxine hydrochloride 15 mg), the proportion of adverse events did not exceed 4.0%. There were no adverse events with the FDC (isoniazid 150 mg + ethambutol 400 mg + pyridoxine hydrochloride 15 mg).Conclusion. Preventive treatment of children with tuberculosis infection with FDC is a modern and effective technology.

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The multicenter observational non-interventional study of combination anti-tuberculosis drugs used in treatment of pulmonary tuberculosis patients

Cited by 2 publications

References 6 publications

Modern approaches to pharmacotherapy of tuberculosis infection in children

Modern approaches to pharmacotherapy of tuberculosis infection in children

Experience of Fixed-Dose Combinations of Anti-Tuberculosis Drugs for Preventive Treatment in Children

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