The natural course of HCV infection and the need for treatment

Bruno, Savino; Facciotto, C.

doi:10.1016/s1665-2681(19)31865-4

Cited by 24 publications

(14 citation statements)

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“…However, we included only patients naive to antiviral therapy to avoid the bias of the interferon effect on both the 13 C-ABT reliability [35] and the natural course of the disease [36]. At present, ethical rules and new guideline recommendations would not allow to enrol HCV-infected patients without considering antiviral therapy.…”

Section: Discussionmentioning

confidence: 99%

13C-Aminopyrine breath test accurately predicts long-term outcome of chronic hepatitis C

Rocco

Nucci

Valente

et al. 2012

Journal of Hepatology

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Section: Discussionmentioning

confidence: 99%

13C-Aminopyrine breath test accurately predicts long-term outcome of chronic hepatitis C

Rocco

Nucci

Valente

et al. 2012

Journal of Hepatology

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“…Over 175 million people are chronically infected by hepatitis C virus (HCV), often resulting in hepatitis, liver fibrosis, cirrhosis and development of hepatocellular carcinoma (HCC)1. The liver consists of unique subsets of antigen presenting cells and lymphocytes2, 3.…”

Section: Introductionmentioning

confidence: 99%

A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease

et al. 2011

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“…Patients who spontaneously clear HCV can be identified by testing positive for antibody to HCV (anti-HCV) in the absence of detectable HCV-RNA [10]. In those who develop chronic infections (anti-HCV positive/HCV-RNA positive) progression to fibrosis, cirrhosis, end stage liver disease, and hepatocellular carcinoma can occur [9, 11–14]. …”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Spontaneous Clearance of Hepatitis C Virus in Chinese Population

Kong

Pan

Chi

et al. 2014

BioMed Research International

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Hepatitis C virus (HCV) infections spontaneously clear in approximately 15–45% of infected individuals. Factors which influence spontaneous HCV clearance remain to be identified. The purpose of the present study was to identify variables associated with spontaneous HCV clearance in a referred population of Chinese patients. The prevalence of host, viral, and environmental factors known to influence the outcome of HCV infections was compared in 92 HCV spontaneous clearance subjects and 318 HCV persistent infection subjects. Univariate and multivariate analyses were performed to identify those factors associated with spontaneous HCV clearance. In univariate analysis, female gender, a history of icteric hepatitis, serologic evidence of concurrent HBV infection, and rs12979860 CC genotype were positively associated with spontaneous HCV clearance, while alcohol consumption was negatively associated with clearance. In multivariate analysis, female gender, a history of icteric hepatitis, concurrent HBV infection, and rs12979860 CC genotype remained independent variables associated with spontaneous HCV clearance. Spontaneous HCV clearance is more likely to occur in females, subjects with a history of icteric hepatitis, HBV coinfections, and those with the rs12979860 CC genotype.

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The natural course of HCV infection and the need for treatment

Cited by 24 publications

References 50 publications

13C-Aminopyrine breath test accurately predicts long-term outcome of chronic hepatitis C

13C-Aminopyrine breath test accurately predicts long-term outcome of chronic hepatitis C

A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease

Factors Associated with Spontaneous Clearance of Hepatitis C Virus in Chinese Population

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