The natural phenolic compounds as modulators of NADPH oxidases in hypertension

Yousefian, Mozhdeh; Shakour, Neda; Hosseinzadeh, Hossein; Hayes, A. Wallace; Hadizadeh, Farzin; Karimi, Gholamreza

doi:10.1016/j.phymed.2018.08.002

Cited by 135 publications

(96 citation statements)

References 122 publications

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“…And phosphorylation of eNOS at serine 1177 enhances its activity [20], which may be directly associated with the difference of the 4 fractions on NO-mediated endothelium-dependent vascular relaxation. This was consistent with the report [21] that phenolic poly-hydroxyl compounds prevented NADPH oxidase expression and ROS production while increasing NO bioavailability.…”

Section: Discussionsupporting

confidence: 94%

The Effects of Lysimachia christinae Hance Extract Fractions on Endothelium-Dependent Vasodilatation

Zhang

Liu

et al. 2019

Pharmacology

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Background: Endothelium-dependent dilatation is a predictor for vascular function. NADPH oxidase-derived O₂^– can inactivate nitric oxide and induce vascular injury. Method: The crude ethanolic extract of Lysimachia christinae Hance were separated out 4 fractions of different olarities by petroleum ether, ethyl acetate, n-butanol (NB), and aqueous. The endothelial integrity was appraised by vascular tension measurement. Dihydroethidium was utilized to observe the vascular reactive oxygen species (ROS) production. Western-blot was adopted to detect protein expression. Results: Among the 4 fractions of L. christinae Hance, the NB fraction showed the most potent capacity of promoting endothelium-dependent vascular relaxation and inhibiting ROS formation in aortic rings, which were likely attributed by suppressing the expression of NAD(P)H oxidase subunit (gp91^phox, p47^phox, and p67^phox) and enhancing the phosphorylation of endothelial NOS in vascular tone. Conclusions: These results suggest that the NB fraction possess the strongest vascular pharmacological activities among the crude ethanolic extract of L. christinae Hance, which may help us for purifying bioactive constituents and discovering new drugs from this herb in future.

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Section: Discussionsupporting

confidence: 94%

The Effects of Lysimachia christinae Hance Extract Fractions on Endothelium-Dependent Vasodilatation

Zhang

Liu

et al. 2019

Pharmacology

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“…PCs present in food have potential inhibitory effects on the activity of NADPH oxidase, scavenge free radicals, and produce an ameliorative role in hypertension (Yousefian et al, 2019). Barraza-Garza et al (2020) showed that a higher polyphenol amount showed better protection against oxidative stress in in vitro cell culture.…”

Section: Antioxidants Propertiesmentioning

confidence: 99%

Concept, mechanism, and applications of phenolic antioxidants in foods

2020

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In this review, the concept of phenolic antioxidants, mechanisms of action, and applications have been reviewed. Phenolic compounds (PCs) acts as an antioxidant by reacting with a variety of free radicals. The mechanism of antioxidant actions involved either by hydrogen atom transfer, transfer of a single electron, sequential proton loss electron transfer, and chelation of transition metals. In foods, the PCs act as antioxidants which are measured with several in vitro spectroscopic methods. The PCs have been found in milk and a wide range of dairy products with sole purposes of color, taste, storage stability, and quality enhancement. The role of PCs in three types of food additives, that is, antimicrobial, antioxidant, and flavoring agents have been critically reviewed. The literature revealed that PCs present in a variety of foods possess several health benefits such as antibacterial, antihyperlipidemic, anticancer, antioxidants, cardioprotective, neuroprotective, and antidiabetic properties. Practical applications Phenolic compounds are strong antioxidants and are safer than synthetic antioxidants. The wide occurrence in plant foods warranted continuous review applications. This review, therefore, presented an updated comprehensive overview of the concept, mechanism, and applications of phenolic antioxidants in foods.

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“…Previous studies have indicated the beneficial effects of sirtuins as the best small molecule that activate sirtuins, which extended lifespan in a yeast model [104][105][106][107][108][109]. Although only the longevity extension effect of resveratrol has been reported in C. elegans and D. melanogaster, many subsequent studies reported that resveratrol intake promotes health and plays a preventive role in age-related diseases, such as cancer [110][111][112][113], atherosclerosis [114,115], arthritis [116,117], cataract [118][119][120], cardiovascular disease [121], hypertension [122,123], type 2 diabetes [124][125][126][127], osteoporosis [128][129][130], and Alzheimer disease [131][132][133]. In clinical studies, resveratrol intake improved the memory capacity of elderly individuals and reduced blood lipid levels in obese and type 2 diabetic patients [134,135].…”

Section: Resveratrolmentioning

confidence: 99%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

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Chronic inflammation, a pervasive feature of the aging process, is defined by a continuous, multifarious, low-grade inflammatory response. It is a sustained and systemic phenomenon that aggravates aging and can lead to age-related chronic diseases. In recent years, our understanding of age-related chronic inflammation has advanced through a large number of investigations on aging and calorie restriction (CR). A broader view of age-related inflammation is the concept of senoinflammation, which has an outlook beyond the traditional view, as proposed in our previous work. In this review, we discuss the effects of CR on multiple phases of proinflammatory networks and inflammatory signaling pathways to elucidate the basic mechanism underlying aging. Based on studies on senoinflammation and CR, we recognized that senescence-associated secretory phenotype (SASP), which mainly comprises cytokines and chemokines, was significantly increased during aging, whereas it was suppressed during CR. Further, we recognized that cellular metabolic pathways were also dysregulated in aging; however, CR mimetics reversed these effects. These results further support and enhance our understanding of the novel concept of senoinflammation, which is related to the metabolic changes that occur in the aging process. Furthermore, a thorough elucidation of the effect of CR on senoinflammation will reveal key insights and allow possible interventions in aging mechanisms, thus contributing to the development of new therapies focused on improving health and longevity.

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The natural phenolic compounds as modulators of NADPH oxidases in hypertension

Cited by 135 publications

References 122 publications

The Effects of <b><i>Lysimachia christinae Hance</i></b> Extract Fractions on Endothelium-Dependent Vasodilatation

The Effects of <b><i>Lysimachia christinae Hance</i></b> Extract Fractions on Endothelium-Dependent Vasodilatation

Concept, mechanism, and applications of phenolic antioxidants in foods

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

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