The Nature of the Inhibitory Effect of Normal Human Gastric Jiuice on Heidenhain Pouch Dogs

Smith, William O.; Hoke, Robert Sebastian; Landy, Jerome J.; Caputto, Ranwel; Wolf, Stewart

doi:10.1016/s0016-5085(58)80100-6

Cited by 22 publications

(6 citation statements)

References 9 publications

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“…(1) mild chronic inflammation, oedema and lymphoid follicles; or (2) a moderate chronic inflammatory infiltrate with occasional polymorphonuclear leucocytes and increased amounts of connective tissue. The former histologic picture has been referred to by previous authors as a positive result, induced by their experimental method (Smith et al, 1958;Hennes et al, 1962;Krohn et al, 1968). However, we found this histologic picture in the pre-immunisation biopsies of our control and test dogs with normal pouch secretion and normal serology, and similar findings have been described in a standard histology test of domestic animals (Trautman et al, 1957).…”

Section: Discussionmentioning

confidence: 92%

“…Intravenous injection of human gastric juice into dogs was shown to have an immediate inhibitory effect on gastric secretion by Brunschwig et al (1939). Subsequently, Smith, Joel and Wolf (1958), and Smith et al (1958), described histologic gastritis as well as decreased secretion in dogs following intravenous injection of human gastric juice. Later, the same group (Hennes et al, 1962), reported the production of atrophic gastritis following the injection of gastric juice with Freund's adjuvant into dogs, and suggested an immunologic mechanism as the basis for these findings.…”

Section: Introductionmentioning

confidence: 99%

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Induction of autoallergic gastritis in dogs

Porteous

Fisher

Lewin

et al. 1974

The Journal of Pathology

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Induction of autoallergic gastritis in dogs

Porteous

Fisher

Lewin

et al. 1974

The Journal of Pathology

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“…The authors noted that the most pronounced inhibition was obtained from the gastric juice of patients with achlorhydria, and only to a lesser degree from extracts of normal gastric juice. The inhibition phenomenon has been confirmed by several investigators (Blackburn and Code 1948, Blackburn et al 1950, and Smith et al 1958. Gastric juice extracts from humans have been shown to inhibit gastric secretion in the rat (Menguy and Smith 1959, 1960, Katzka 1962, Nell and Barnard 1963.…”

mentioning

confidence: 79%

The Effects of a Gastric Inhibitory Substance on Gastric Secretion in the Pylorus Ligated Rat¹

Semb

1966

Acta Physiologica Scandinavica

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An extract was prepared from juice secreted by vagally denervated isolated pouches of the gastric antrum in the dog, by dialyzing against water and lyophilization. This gastric inhibitory substance (GIS) was assayed in pylorus ligated rats. Three groups of rats served as controls. One group received no injections, while the two other were injected with saline (1 ml/100 g rat) intravenously (i.v.) or intraperitoneally (i.p.). Two different types of gastric secretion were studied: (a) basal or spontaneous gastric output, and (b) gastric acid response to exogenous gastrin. GIS lowered significantly the basal or spontaneous output of acid, but did not alter the basal output of pepsin significantly. When GIS was injected into animals stimulated by gastrin, there was a highly significant lower output of both acid and pepsin.

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“…Purification of intrinsic factor has reached a sample effective in 3 mg. doses and showing only three sedimentation peaks (41) . Workers in Wolf's laboratory (42) in their purification of inhibitory substance found in normal human gastric juice and saliva obtained a fraction, either a small mucoprotein or a carbo hydrate, which is released from the antrum and which requires vagal inner vation for its secretion. It is active in small doses and has profoundly im portant long-term properties, review of which must unfortunately wait transfer of information from progress report and gossip to definitive publica tion.…”

Section: Gastric Secretionmentioning

confidence: 99%

“…Both cephalic and intestinal phases of gastric secretion can also be inhibited by perfusing an antral pouch with acid (131,132) . Is this inhibition mediated by Wolf's (42) inhibitor? A number of thoroughly confusing observations (133,134,135) on the effect of surgical manipulation of the antrum would become clearer if this were so.…”

Section: Coordination Of Digestive Functionsmentioning

confidence: 99%

Digestive System

Davenport

1959

Annu. Rev. Physiol.

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To understand digestion we need first a gross, qualitative description of the fate of ingesta; what is secreted in response to the meal, how ingesta are transformed by reaction with secretions and by the propulsive mechanism, what is absorbed and what rejected. This should be followed by an exact quantitative and temporal description in the style of chemical kinetics in which net changes are reported in terms of two-way fluxes. Coupled with this should be a detailed account of the physiological and morphological basis of secretion, transformation, and absorption reaching down to the deepest levels at which anatomy, biochemistry, and biophysics become indistinguishable one from another. Finally we require a description complete at all levels of controlling processes. Then we can put the fragments of our knowledge to sether to characterize what happens in the gut.2Descriptive, analytical, and synthetic aspects of our knowledge of diges tion are incomplete, for gastroenterological physiology suffers from difficul ties inherent in all biological science. Even summary descriptions must fre quently be revised as we gain new tools and insights, and scientific attack does not proceed in an orderly manner. Before we had learned to describe di gestion in simple terms there were triumphs of analysis, as for example the discovery of the secretin mechanism, but we cannot say how individual parts cooperate to perform the total function. In addition, gastroenterological physiology has its peculiar troubles. What is ingested may range from a ten course dinner served at the Duchess of Guermantes' to repulsive mixtures of mud and mush appropriately called "test meals." There are wide species dif ferences, and even within one species the digestive apparatus shows great functional variability. Consequently, when we come to describe what actu ally occurs during digestion we must specify what meal was eaten by what animal under what circumstances. SECRETION FROM THE SALIVARY GLANDSNot only do salivary glands differ from species to species, but several glands in one animal secrete juices of different compositions. The parotid 1 This review considers selected aspects of the recent literature available in the University of Michigan library at the end of May, 1958. 2 Papers on the following phases of digestion are cited for completeness but will not be discussed: on secretion (161 to 172); on the pancreas (173 to 177); on bile ( 178 to 182); on absorption (183 to 199); on cholesterol absorption (200 to 210); on neuro physiology (211 to 217); on smooth muscle (218 to 220); on the esophagus (221 to 228); on regulation (218 to 229); on the effects of drugs and 5-hydroxytryptamine (229 to 242); on growth, injury, and repair (24.3 to 249); on blood flow (250 to 255); and on methods (257 to 263). 183Annu. Rev. Physiol. 1959.21:183-210. Downloaded from www.annualreviews.org Access provided by Western Michigan University on 02/03/15. For personal use only.Quick links to online content Further ANNUAL REVIEWS 184 DAVENPORT gland of dog and man s...

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The Nature of the Inhibitory Effect of Normal Human Gastric Jiuice on Heidenhain Pouch Dogs

Cited by 22 publications

References 9 publications

Induction of autoallergic gastritis in dogs

Induction of autoallergic gastritis in dogs

The Effects of a Gastric Inhibitory Substance on Gastric Secretion in the Pylorus Ligated Rat¹

Digestive System

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The Nature of the Inhibitory Effect of Normal Human Gastric Jiuice on Heidenhain Pouch Dogs

Cited by 22 publications

References 9 publications

Induction of autoallergic gastritis in dogs

Induction of autoallergic gastritis in dogs

The Effects of a Gastric Inhibitory Substance on Gastric Secretion in the Pylorus Ligated Rat1

Digestive System

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The Effects of a Gastric Inhibitory Substance on Gastric Secretion in the Pylorus Ligated Rat¹