The Need for Manganese in the Bone Development of the Chick

Caskey, C. D.; Gallup, Willis D.; Norris, L. C.

doi:10.1093/jn/17.5.407

Cited by 45 publications

(8 citation statements)

References 22 publications

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“…Although it is evident that there is a relationship between Zn and F, the regression coefficient is not very high, allowing also other interrelations concerning F. In the reduced model of Zn as well as of Cu, Mn was a significant explanatory factor. The role of Mn has been clearly established as essential for normal skeletal development (Caskey et al 1939, Hurley et al 1961. Furthermore Mn is the important ion in the metabolism of mucopolysaccharides (Leach 197 1) affecting the formation of the organic matrix of bone.…”

Section: Discussionmentioning

confidence: 99%

Zn and Cu Content in Human Cancellous Bone

Lappalainen

Knuuttila

Lammi

et al. 1982

Acta Orthopaedica Scandinavica

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Section: Discussionmentioning

confidence: 99%

Zn and Cu Content in Human Cancellous Bone

Lappalainen

Knuuttila

Lammi

et al. 1982

Acta Orthopaedica Scandinavica

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“… 9 It was involved in the formation of chondroitin sulfate via polymerization and galactotransferase processes; 10 this is the most important step in bone hyaline cartilage structure. So, any deficiency in Mn causes significant reduction in bone size, 11 likely due to reduced chondroitin sulfate content of the bone organic matrix. 10 Also, zinc is a cofactor of both collagenase 12 and bone alkaline phosphatase.…”

Section: Introductionmentioning

confidence: 99%

Correlation between bone mineral density and serum trace elements in response to supervised aerobic training in older adults

Alghadir

Gabr

Al-Eisa

et al. 2016

CIA

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BackgroundLife style and physical activity play a pivotal role in prevention and treatment of osteoporosis. The mechanism for better bone metabolism and improvement of physical disorders is not clear yet. Trace minerals such as Ca, Mn, Cu, and Zn are essential precursors for most vital biological process, especially those of bone health.ObjectiveThe main target of this study was evaluating the effective role of supervised aerobic exercise for 1 hour/day, 3 days/week for 12 weeks in the functions of trace elements in bone health through measuring bone mineral density (BMD), osteoporosis (T-score), bone markers, and trace element concentrations in healthy subjects aged 30–60 years with age average of 41.2±4.9.MethodsA total of 100 healthy subjects (47 males, 53 females; age range 30–60 years) were recruited for this study. Based on dual-energy x-ray absorptiometry (DEXA) scan analysis, the participants were classified into three groups: normal (n=30), osteopenic (n=40), and osteoporotic (n=30). Following, 12 weeks of moderate aerobic exercise, bone-specific alkaline phosphatase (BAP), BMD, T-score, and trace elements such as Ca, Mn, Cu, and Zn were assessed at baseline and post-intervention.ResultsSignificant improvement in serum BAP level, T-score, and BMD were observed in all participants following 12 weeks of moderate exercise. Participants with osteopenia and osteoporosis showed significant increase in serum Ca and Mn, along with decrease in serum Cu and Zn levels following 12 weeks of aerobic training. In control group, the improvements in serum trace elements and body mass index were significantly linked with the enhancement in the levels of BAP, BMD hip, and BMD spine. These results supported the preventive effects of moderate exercise in healthy subjects against osteoporosis. In both sexes, the changes in serum trace elements significantly correlated (P<0.05) with the improvement in BAP, BMD hip, BMD spine, and body mass index in all groups.ConclusionThe observed changes in the levels of Ca, Mn, Cu, and Zn were shown to be positively correlated with improved bone mass density among control and osteoporosis subjects of both sexes. These results demonstrate that aerobic exercise of moderate intensity might protect bone and cartilage by regulation of body trace elements which are involved in the biosynthesis of bone matrix structures and inhibition of bone resorption process via a proposed anti-free radical mechanism.

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“…Manganese is known to be an essential trace element for growth and reproduction in many animals, including mice, rats, chickens, pigs and guinea pigs (1â€"6).It is particularly important for the growth and development of the skeleton during both embryonic and juvenile periods of growth (7)(8)(9)(10)(11)(12)(13). The effects on skeletal growth ap pear to be mediated by changes in mucopolysaccharide synthesis, involving the cartilaginous matrices of forming bones (14)(15)(16).…”

mentioning

confidence: 99%

Congenital Ataxia and Otolith Defects Due to Manganese Deficiency in Mice

Erway

Hurley

Fraser

1970

The Journal of Nutrition

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Manganese deficiency in mice caused congenital ataxia in some prog eny. The most diagnostic means of detecting the ataxia was to place all mice in a tank of water and observe their ability to maintain a normal, upright position. The incidence of ataxia increased approximately in proportion to the duration and severity of the manganese-deficient state of the mother. Cleared otic capsules revealed that otoliths were reduced in size, or were absent, in many of the manganese-deficient progeny. Supplementation of the manganese-deficient females after day 14 of gestation was ineffective in reducing the incidence of the otolithic effect. Supplementation between days 12 and 14 was only partially effective, whereas supplementation starting on day 11 was sufficient for completely normal development of otoliths. The absence of oto lithic crystals is attributed to a defect in the synthesis of the organic matrix which appears to be composed of acid mucopolysaccharides. The absence of otoliths was also found in manganese-deficient chicks and presumably explains the long-standing reports of ataxia due to manganese deficiency in poultry and other domestic animals.

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The Need for Manganese in the Bone Development of the Chick

Cited by 45 publications

References 22 publications

Zn and Cu Content in Human Cancellous Bone

Zn and Cu Content in Human Cancellous Bone

Correlation between bone mineral density and serum trace elements in response to supervised aerobic training in older adults

Congenital Ataxia and Otolith Defects Due to Manganese Deficiency in Mice

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