The Negative Bidirectional Interaction Between Climate Change and the Prevalence and Care of Liver Disease: A Joint BSG, BASL, EASL, and AASLD Commentary

Donnelly, Mhairi; Stableforth, William; Krag, Aleksander; Reuben, Adrian

doi:10.1053/j.gastro.2022.02.020

Cited by 13 publications

(8 citation statements)

References 41 publications

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“…The intersection between climate change and NAFLD is underappreciated but becoming increasingly relevant. Agricultural infrastructure set up to provide food and other resources has been collapsing as scarcity of available land, drought, wildfires, and the frequency of major storms directly influence farming (Donnelly et al, 2022). This in turn contributes to increasing rates of obesity as more people increasingly rely on processed foods (Donnelly et al, 2022).…”

Section: Linkage Between Climate Change Non-alcoholic Fatty Liver Dis...mentioning

confidence: 99%

“…Agricultural infrastructure set up to provide food and other resources has been collapsing as scarcity of available land, drought, wildfires, and the frequency of major storms directly influence farming (Donnelly et al, 2022). This in turn contributes to increasing rates of obesity as more people increasingly rely on processed foods (Donnelly et al, 2022). Obesity has been linked to development of insulin resistance, and both contribute to the development of NAFLD.…”

Section: Linkage Between Climate Change Non-alcoholic Fatty Liver Dis...mentioning

confidence: 99%

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Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines

et al. 2022

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Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world and one of the leading indications for liver transplantation. It is one of the many manifestations of insulin resistance and metabolic syndrome as well as an independent risk factor for cardiovascular disease. There is growing evidence linking the incidence of NAFLD with psychiatric illnesses such as schizophrenia, bipolar disorder and depression mechanistically via genetic, metabolic, inflammatory and environmental factors including smoking and psychiatric medications. Indeed, patients prescribed antipsychotic medications, regardless of diagnosis, have higher incidence of NAFLD than population norms. The mechanistic pharmacology of antipsychotic-associated NAFLD is beginning to emerge. In this review, we aim to discuss the pathophysiology of NAFLD including its risk factors, insulin resistance and systemic inflammation as well as its intersection with psychiatric illnesses.

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Section: Linkage Between Climate Change Non-alcoholic Fatty Liver Dis...mentioning

confidence: 99%

Section: Linkage Between Climate Change Non-alcoholic Fatty Liver Dis...mentioning

confidence: 99%

Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines

et al. 2022

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“…The downstream effects of climate change on health may affect GI practice in a variety of ways. Food insecurity and malnutrition can contribute to obesity and fatty liver disease, for example, 3,21,22 which in turn may further derange the microbiome and impair gut immune function 23–25 . Climate change has led to a changing pattern of infectious diseases with an increased risk for diarrheal diseases and hepatitis, 1 with morbidity and mortality often exacerbated by the unsanitary conditions of forced migration and limited access to clean water 7,10 .…”

Section: Figurementioning

confidence: 99%

GI multisociety strategic plan on environmental sustainability

et al. 2022

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“…Climate sensitive mycotoxins from fungi have been linked to hepatocellular carcinoma. Adverse effects on food security can lead to a paradoxical increase in obesity and non-alcoholic fatty liver disease 10. Other concerning aspects of environmental sustainability include the use of non-recyclable plastic waste (or potentially recyclable plastic waste that is not recycled), We witness this in many aspects of our practice, and there is an opportunity to address this.…”

Section: Introductionmentioning

confidence: 99%

Greener gastroenterology and hepatology: the British Society of Gastroenterology Strategy for Climate Change and Sustainability

Veitch

2022

Frontline Gastroenterol

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There is a global climate emergency, and also a global health concern related to climate change. The British Society of Gastroenterology (BSG) acknowledges these issues, and supports the concerns of its members to address them. Climate change has adverse effects on gastroenterological and liver disease, and on healthcare systems. The healthcare industry, itself, is also a major contributor to greenhouse gases. BSG has developed a strategy on Climate Change and Sustainability, which encompasses all of the activities of the society, and its members: personal, professional, organisational, political, international and research.

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The Negative Bidirectional Interaction Between Climate Change and the Prevalence and Care of Liver Disease: A Joint BSG, BASL, EASL, and AASLD Commentary

Cited by 13 publications

References 41 publications

Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines

Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines

GI multisociety strategic plan on environmental sustainability

Greener gastroenterology and hepatology: the British Society of Gastroenterology Strategy for Climate Change and Sustainability

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