The neolignans of Licaria canella

Giesbrecht, Astrea Mennucci; Franca, Nidia C.; Gottlieb, Otto R.; Rocha, Arnaldo I. Da

doi:10.1016/0031-9422(74)85041-7

Cited by 38 publications

(11 citation statements)

References 6 publications

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“…Found: 165.08. Elemicin ( 2 ), [24]: 1 H NMR δ 3.33 (d, 2H, 3 J = 6.6 Hz, C H 2 ); 3.82 (s, 3H, OC H 3 ); 3.84 (s, 6H, ( H 3 CO)CC(OC H 3 )C(OC H 3 ); 5.08 (dd, 1H, 2 J = 1.8 Hz, 3 J cis = 10 Hz, HC H CHCH 2 ); 5.11 (dd, 1H, 2 J = 1.8 Hz, 3 J trans = 17 Hz, H CHCHCH 2 ); 5.95 (ddd, 1H, 3 J cis = 10 Hz, 3 J trans = 17 Hz, 3 J = 6.6 Hz, HCHC H CH 2 ); 6.40 (s, 2H, 2 × aromatic H ). MS calculated for C 12 H 16 O 3 Na [ M + Na] + : 231.11.…”

Section: Methodsmentioning

confidence: 99%

Isolation of Bioactive Compounds That Relate to the Anti‐Platelet Activity of Cymbopogon ambiguus

Grice

Rogers

Griffiths

2011

Evidence-Based Complementary and Alternative Medicine

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Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant's anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6 μM, in comparison to aspirin, with an IC50 value of 46.1 μM. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions.

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Section: Methodsmentioning

confidence: 99%

Isolation of Bioactive Compounds That Relate to the Anti‐Platelet Activity of Cymbopogon ambiguus

Grice

Rogers

Griffiths

2011

Evidence-Based Complementary and Alternative Medicine

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“…Comparando com os valores obtidos para a quercetina (CE 50 de 4,13μg.mL -1 ), o extrato em etanol dos galhos de L. martiniana foi o que se comportou de forma mais semelhante ao padrão.Em alguns trabalhos sobre a composição química das espécies desse gênero relata-se a presença de lignanas furofurânicas (Alegrio et al 1981), monoterpenos, sesquiterpenos (Maia et al 1985) e o fenilpropanoides (Giesbrecht et al 1974).…”

Section: Resultsunclassified

Investigação do potencial antioxidante e anticolinesterásico de 20 espécies da família Lauraceae

2012

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Lauraceae é uma das famílias mais importantes na floresta amazônica. Diversas de suas espécies apresentam em sua composição substâncias com pronunciadas atividades biológicas. Nesse trabalho, os extratos obtidos em etanol de galhos e folhas de 20 espécies de Lauraceae foram coletados na Reserva Florestal Ducke e avaliados quant o às atividades antioxidante frente ao radical livre 2,2-difenil-1-picrilhidrazila(DPPH) e inibidora da enzima acetilcolinesterase. O extrato dos galhos de Licaria martinianal apresentou a maior capacidade de sequestro do radical DPPH (6,96 µg.mL-1),mas os extratos de Ocotea iminor foram os mais ativos na inibição da enzima acetilcolinesterase, apresentando também pronunciada atividade antioxidante. O perfil de atividade antioxidante e anticolinesterásico destes extratos está sendo relatado pela primeira vez neste trabalho.

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“…Compound 85 was isolated from the benzene extract of trunk wood of an unclassified Aniba species [50]. Canellin B ( 86 ) was first obtained from the benzene extract of the trunk wood of Licaria canella [51]. The trunk wood of an Amazonian Aniba species contained armenin A ( 81 ), armenin B ( 82 ), C ( 83 ), canellin B ( 86 ), canellin D ( 87 ), canellin E ( 88 ), porosin ( 90 ), and porosin B ( 91 ) [52].…”

Section: Neolignansmentioning

confidence: 99%