2003
DOI: 10.1007/978-3-7091-0643-3_8
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The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour

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Cited by 171 publications
(199 citation statements)
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“…Second, iron concentrations in the SNc that increase with age can mask signal alterations on NmMRI. 3 Therefore, we could not exclude this effect when evaluating neuromelanin in elderly individuals. Third, the low spatial resolution of NmMRI did not allow 3D image acquisition.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Second, iron concentrations in the SNc that increase with age can mask signal alterations on NmMRI. 3 Therefore, we could not exclude this effect when evaluating neuromelanin in elderly individuals. Third, the low spatial resolution of NmMRI did not allow 3D image acquisition.…”
Section: Discussionmentioning
confidence: 99%
“…2 It is thought to be formed as a by-product of the catecholamine metabolism cascade through enzymatic and/or oxidative polymerization. 2,3 PD is characterized by the progressive loss of dopaminergic neurons that contain neuromelanin in the SNc and of noradrenergic neurons in the LC. Several pathologic studies have shown the selective loss of ventral intermediate and lateral cell groups of the SNc in PD.…”
mentioning
confidence: 99%
“…Neuromelanin appears to result from the autoxidation of dopamine, in a process that generates reactive oxygen species (ROS) [100] The presence of high amounts of iron in PD SN [101], which contribute to the production of free radicals via the FentonͲHaber Weiss reaction, has also been pointed out as a cause for selective degeneration of these neurons. In this reaction, hydrogen peroxide (H 2 O 2 ) generated during normal metabolism, during electron transport in mitochondria, or by pathogenic mechanisms, can be subsequently converted to the extremely toxic hydroxyl radical ( .…”
Section: Sources Of Oxidative Damage In Pdmentioning
confidence: 99%
“…Zecca et al in post-mortem studies detected increased content of iron in the hyperechogenic SN in 40 PD patients. A negative correlation was found between hyperechogenic SN and neuromelanin content of SN 33,34 . Although the exact mechanism by which iron gets redistributed in various region of the brain is poorly understood, it is known that brain cells in certain areas of the brain have variable ability of to accumulate iron.…”
Section: Echogenicity Of Substantia Nigra and Iron Metabolismmentioning
confidence: 86%