The neuroprotective effect of olive leaf extract is related to improved blood–brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia

Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats

“…This observed effect of Olea europaea leaf extract has been attributed to the main component oleuropein (Scheffler et al, 2008). HPLC analysis of olive leaf extract by our colleagues showed that the major constituent of our extract is also oleuropein, comprising 35.6% of the extract (Mohagheghi et al, 2010).…”

“…The collective ethanol extract was filtered, and the filtrate was concentrated to dryness under reduced pressure in a rotary evaporator and the resulting ethanol extract was freeze-dried. Quantification of some identified compounds of the extract using high performance liquid chromatography (HPLC) by our colleagues showed that oleuropein (356 mg/g), tyrosol (3.73), hydroxy tyrosol (4.89) and caffeic acid (49.41) were the main compositions of the olive leaf extract (Mohagheghi et al, 2010). The same extract was also used in this study.…”

Characterization of Phenolic Profiles of Italian Single Cultivar Olive Leaves (Olea europaea L.) by Mass Spectrometry

“…Oleuropein constituents are best known for their blood pressure-lowering effects, but the latest studies reveal their health benefits extend well beyond that. Additional anti-inflammatory and antioxidant properties offer promise in fighting atherosclerosis, diabetes, cancer, neurodegenerative diseases, and even arthritis [17][18][19][20][21][22]. Among the ten analyzed varieties, the amount of oleuropein in olive leaves was higher in August and lower in November.…”

Pretreatment Effect of Alcoholic Olive Leaf Extract on Oxidative and Antioxidative Enzymes Status in Ovariectomized Rats

“…After evaporation of solvent using a rotary evaporator, the remainder of the extract was administered orally (12). Two weeks after surgery, OVX-OLE group received olive leaf extract with dose of 100 mg/kg body weight in 0.5 mL normal saline by gavages for 30 days (13). Rats in the control and OVX groups received 0.5 mL normal saline orally.…”