The nevoid basal cell carcinoma syndrome

Lindeberg, H; Jepsen, F. Løve

doi:10.1111/j.1600-0560.1983.tb00317.x

Cited by 21 publications

(5 citation statements)

References 7 publications

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“…This could be due to differences in lifestyle and skin protection practices, with males less likely to wear sunscreen and protect the face on a daily basis but more likely to wear hats than females, and females more often engaging in risky sunbathing and tanning behaviors that may possibly increase ultraviolet exposure to the legs [Santmyire et al, 2001;Kasparian et al, 2009]. Histologically, all subtypes of BCCs, including the more aggressive micronodular and morphea-like subtypes, were noted in this study, which is similar to the findings of Lindeberg and Jepsen [1983]. Metastatic BCC lesions have also been reported in BCNS and radiotherapy can increase the rate and speed of occurrence [Winkler and Guyuron, 1987;Gorlin, 2004;Manfredi et al, 2004].…”

Section: Discussionsupporting

confidence: 91%

Features of basal cell carcinomas in basal cell nevus syndrome

Tom

Hurley

Oliver

et al. 2011

American J of Med Genetics Pt A

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Basal cell nevus syndrome (BCNS) is an autosomal dominant genodermatosis that is characterized by early onset basal cell carcinomas (BCCs) that define the disease and often lead to diagnosis of the underlying syndrome. The objective of this study was to investigate the anatomic location, subtypes, and impact of BCCs on a group of 61 individuals affected with BCNS attending a research colloquium. Fifty individuals had at least one prior BCC with 22 participants having over 100 lesions. The median age of syndrome diagnosis was 11 years and median age of first BCC was 16 years. Males had more lesions on the upper back, upper extremities, and M-zone of the face, while females had more lesions on the scalp, back, and lower extremities. Pigmented BCCs were concentrated on the neck, upper trunk, and extremities. Subjects with >100 lesions showed wider anatomic distribution. The number of BCCs did not correlate with any of the other major features of the syndrome. Eighty percent of affected individuals reported great concern related to BCCs, citing the limitations and morbidity of available treatments. Vigilant surveillance, which was found to be inconsistent for participants in this study, is warranted. Future work should include development of a consensus guideline on skin examinations and strategies to optimize therapy of BCCs in this syndrome.

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Section: Discussionsupporting

confidence: 91%

Features of basal cell carcinomas in basal cell nevus syndrome

Tom

Hurley

Oliver

et al. 2011

American J of Med Genetics Pt A

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“…This could be due to differences in lifestyle and skin protection practices, with males less likely to wear sunscreen and protect the face on a daily basis but more likely to wear hats than females, and females more often engaging in risky sunbathing and tanning behaviors that may possibly increase ultraviolet exposure to the legs [Santmyire et al, 2001; Kasparian et al, 2009]. Histologically, all subtypes of BCCs, including the more aggressive micronodular and morphea‐like subtypes, were noted in this study, which is similar to the findings of Lindeberg and Jepsen [1983]. Metastatic BCC lesions have also been reported in BCNS and radiotherapy can increase the rate and speed of occurrence [Winkler and Guyuron, 1987; Gorlin, 2004; Manfredi et al, 2004].…”

Section: Discussionsupporting

confidence: 88%

Argon‐based atmospheric pressure plasma enhances early bone response to rough titanium surfaces

Coelho

Giro

Teixeira

et al. 2012

J Biomedical Materials Res

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This study investigated the effect of an Argon-based atmospheric pressure plasma (APP) surface treatment operated chairside at atmospheric pressure conditions applied immediately prior to dental implant placement in a canine model. Surfaces investigated comprised: rough titanium surface (Ti) and rough titanium surface + Argon-based APP (Ti-Plasma). Surface energy was characterized by the Owens-Wendt-Rabel-Kaelble method and chemistry by X-ray photoelectron spectroscopy (XPS). Six adult beagles dogs received two plateau-root form implants (n = 1 each surface) in each radii, providing implants that remained 1 and 3 weeks in vivo. Histometric parameters assessed were bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Statistical analysis was performed by Kruskall-Wallis (95% level of significance) and Dunn's post-hoc test. The XPS analysis showed peaks of Ti, C, and O for the Ti and Ti- Plasma surfaces. Both surfaces presented carbon primarily as hydrocarbon (C-C, C-H) with lower levels of oxidized carbon forms. The Ti-Plasma presented large increase in the Ti (+11%) and O (+16%) elements for the Ti- Plasma group along with a decrease of 23% in surface-adsorbed C content. At 1 week no difference was found in histometric parameters between groups. At 3 weeks significantly higher BIC (>300%) and mean BAFO (>30%) were observed for Ti-Plasma treated surfaces. From a morphologic standpoint, improved interaction between connective tissue was observed at 1 week, likely leading to more uniform and higher bone formation at 3 weeks for the Ti-Plasma treated implants was observed.

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“…The syndrome presents a dominant autosomal transmission (2,12) and one third of the patients do not have previous family history thus suggesting mutation or incomplete penetration of the gene (5).…”

Section: Introductionmentioning

confidence: 99%

Nevoid Basal-Cell Syndrome: literature review and case report in a family

et al. 1995

Sao Paulo Med. J.

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The Nevoid Basal-Cell Carcinoma Syndrome (NBCC), or as it is also referred to, basal-cell nevus syndrome or Gorlin-Goltz syndrome, is characterized by multiple early-appearing basal cell carcinomas, keratocytosis of the mandible, and anomalies of the ocular, skeletal reproductive system. We describe four patients in the same family, all of them possessing a large number of skin tumors associated with other typical clinical and X-Ray anomalies of NBCC. The definitive treatment of NBCC has yet to be established, however, early diagnosis is very important as well as the periodical follow-up examination of ten patients, mainly due to the transformations in the skin lesions that may occur.

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The nevoid basal cell carcinoma syndrome

Cited by 21 publications

References 7 publications

Features of basal cell carcinomas in basal cell nevus syndrome

Features of basal cell carcinomas in basal cell nevus syndrome

Argon‐based atmospheric pressure plasma enhances early bone response to rough titanium surfaces

Nevoid Basal-Cell Syndrome: literature review and case report in a family

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