The normal range and determinants of the intrinsic heart rate in man

Jose, Anthony D.; Collison, Damien

doi:10.1093/cvr/4.2.160

Cited by 519 publications

(249 citation statements)

References 0 publications

Supporting

Mentioning

225

Contrasting

Unclassified

Order By: Relevance

“…We thus were able to conduct a second Holter monitoring in 19 subjects from whom we obtained informed consent ( Figure 1, Step II). We then verified again that they did not have any heart diseases or were taking any Vol 47 No 4 drugs which could affect their heart rate and/or rhythm, when conducting the second Holter monitoring. We excluded subjects whose Holter recording revealed recording failure or a pathological finding.…”

Section: Study Population and Holter Monitoringmentioning

confidence: 99%

Longitudinal Age-Related Changes in 24-Hour Total Heart Beats and Premature Beats and Their Relationship in Healthy Elderly Subjects

et al. 2006

View full text Add to dashboard Cite

SUMMARYThe aim of this study was to conduct a longitudinal follow-up on age-related changes in 24-hour total heart beats (THBs) and total premature beats and their correlations in healthy elderly subjects. In 15 healthy elderly subjects (mean age, 70.0 ± 4.1, age range at 1st recording, 64 to 80 years, 10 females, 5 males), we conducted Holter monitoring twice at an interval of 15 years and analysed age-related changes in THBs, atrial premature beats (APBs), and ventricular premature beats (VPBs), as well as their correlations.The results indicated that THBs, APBs, and VPBs all significantly increased with age in the healthy elderly subjects at a mean age of 70.0 ± 4.1 (THB: 91074.1 ± 11515.3 versus 99457.5 ± 12131.0; P = 0.0004, APB:119.2 ± 97.8 versus 884.4 ± 1193.8; P = 0.0008, VPB: 15.2 ± 53.6 versus 140.7 ± 228.9; P = 0.0328). Moreover, we divided the subjects into increase and nonincrease groups based on the age-related changes in APB and VPB for 15 years ([n]; Inc-APB: Noninc-APB = 6 : 9, Inc-VPB: Noninc-VPB = 5 : 10). In the increase groups, premature beats tended to increase in proportion to changes in THBs with age (APB: Y = 207.488 + 0.136 * X, r = 0.848, P = 0.0303; VPB: Y = -27.594 + 0.028 * X, r = 0.727, P = 0.1921).In conclusion, this 15-year follow-up of Holter recordings in healthy elderly subjects revealed that THBs, APBs, and VPBs increased with age, and that the increases in premature beats, especially APBs, were in proportion to those in THBs. (Int Heart J 2006; 47: 549-563) Key words: 24-hour total heart beat, Atrial premature beat, Ventricular premature beat, Healthy elderly subject, Age-related change IN general, in healthy adults younger than 70 years old, maximum heart rate (HR) on exercise, maximum and mean HR during Holter monitoring, and intrinsic HR after pharmacological autonomic block are known to decrease with age.

show abstract

Section: Study Population and Holter Monitoringmentioning

confidence: 99%

Longitudinal Age-Related Changes in 24-Hour Total Heart Beats and Premature Beats and Their Relationship in Healthy Elderly Subjects

et al. 2006

View full text Add to dashboard Cite

show abstract

“…In all patients, the IHRo was higher than the RHR and was within the normal range of IHRp based on the formula of Jose and Collison. 20 The maximal CSNRT was 110-240 msec (mean 167 ± 39 msec). The mean CSNRT was 140 + 19 msec in the patients 45 years or younger and 194 i 36 msec in the patients older than 45 years.…”

mentioning

confidence: 92%

Electrophysiology of normal sinus node with and without autonomic blockade.

Alboni¹,

Malcarne²,

Pedroni³

et al. 1982

Circulation

View full text Add to dashboard Cite

show abstract

“…The parasympathetic nervous system exerts a tonic inhibitory influence over the sinoatrial node. This is exemplified by the evidence that the intrinsic heart period (under both parasympathetic and sympathetic blockades) is shorter than resting heart period under basal conditions (26). Other cardiovascular parameters are also under the regulation of the ANS, including myocardial contractility and vascular resistance.…”

Section: Discussionmentioning

confidence: 99%

Photoperiod alters autonomic regulation of the heart

Weil

Norman

DeVries

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Outside of the tropics, environmental conditions fluctuate in a generally predictable manner across the year. Many small mammals have evolved mechanisms, such as seasonal breeding and annual adjustments in physiology, morphology, and behavior, that promote winter survival when food is scarce and thermoregulation is challenging. Photoperiod (day length) is a cue used by many seasonal breeders to predict seasonal changes in environmental conditions. One system that is uniquely situated to mediate photoperiod-induced alterations in physiology is the autonomic nervous system (ANS). The 2 branches of the ANS are key regulators of immune responses, thermoregulation, and energy balance, functions that undergo marked shifts in baseline and reactivity following acclimation to short day lengths. Although previous studies have investigated the effects of photoperiod on ANS endpoints, this study examined the direct effects of photoperiod on integrated ANS function. To test the hypothesis that short day lengths increase parasympathetic and sympathetic tones, we maintained adult male Siberian hamsters (Phodopus sungorus) to either long or short photoperiods and then analyzed electrocardiogram recordings. Short day lengths increased both parasympathetic tone, as measured by respiratory sinus arrhythmia, and sympathetic control of the heart, measured with autonomic blockade. Additionally, short day lengths enhanced the withdrawal of parasympathetic control and the increase of sympathetic tone in response to acute restraint stress. Finally, these effects were discovered to be independent of circulating androgens. These data indicate that the ANS of Siberian hamsters undergoes profound changes following prolonged exposure to short winter-like day lengths.autonomic nervous system ͉ cardiovascular ͉ parasympathetic ͉ sympathethic ͉ day length F or animals living outside of the tropics, life is characterized by dramatic daily and seasonal fluctuations in illumination, ambient temperatures, food availability, and predation pressures; adapting to this variation is critical for reproductive success and survival (1). Although variation in environmental conditions is inexorable, it is also generally predictable, and many vertebrate species have evolved mechanisms that allow for adjustment of physiology, behavior, and morphology to anticipate favorable and unfavorable energetic conditions at different times of the year (2). Because many such processes require significant time to develop, natural selection has favored individuals that have the capacity to measure day length (photoperiod) to predict annual variation in the environment (3).Seasonal reproduction, which is characterized by long-day breeding during spring and summer, when environmental conditions are relatively mild, and regression of reproductive function during short, winter-like day lengths, when energy demands are high, is canonical among the photoperiodic and circannual adjustments made by small mammals (4). Although reproductive function is the most studied response to ch...

show abstract

The normal range and determinants of the intrinsic heart rate in man

Cited by 519 publications

References 0 publications

Longitudinal Age-Related Changes in 24-Hour Total Heart Beats and Premature Beats and Their Relationship in Healthy Elderly Subjects

Longitudinal Age-Related Changes in 24-Hour Total Heart Beats and Premature Beats and Their Relationship in Healthy Elderly Subjects

Electrophysiology of normal sinus node with and without autonomic blockade.

Photoperiod alters autonomic regulation of the heart

Contact Info

Product

Resources

About