The nosological structure of years of potential life lost in the economically active age in the Russian Federation in 2016

Drapkina, О. М.; Samorodskaya, I. V.; Болотова, Е. В.; Starinskaya, M. A.

doi:10.17116/profmed20192201122

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Женщины в менопаузе по сравнению с мужчинами имеют больше ранних дифференцированных адипоцитов, особенно в бедренной области [15]. В периоде менопаузального перехода и ранней постменопаузе избыточная масса тела и ожирение по некоторым данным регистрируются более чем у половины женщин [16].…”

Section: показатели контроль-бо-м насп-о-м рunclassified

Clinical and laboratory features of the course of non-alcoholic liver steatosis in women in the early postmenopausal period living on the territory of an industrial megapolis

Булатова

Shevlyukova

Sobol³

et al. 2023

jour

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The aim. To study risk factors, clinical features, anthropometric, biochemical and metabolic parameters, parameters of the functional state of the endothelium, the level of interleukin-6 (IL-6) and markers of hemostasis in patients with non-alcoholic liver steatosis in the early postmenopausal period living in Perm. Materials and methods. 100 women in the early postmenopausal period were examined: 70 patients with the clinical form non-alcoholic liver steatosis and overweight or obesity of varying severity (49.9±1.1 years) and 30 practically healthy women without obesity and liver pathology (47.3±2.6 years). Biochemical parameters, lipid spectrum, insulin, leptin, leptin receptors, interleukin-6 (IL-6), markers of endothelial dysfunction, hemostasis parameters were determined in the blood of all subjects, body mass index (BMI), free leptin index, NOMA-IR and Caro were calculated. Liver steatosis was determined by ultrasound examination. Results. General weakness (35%), severity (35%) and pain (15%) in the right hypochondrium (35%), dyspepsia - belching (25%), nausea (15%), heartburn (10%), flatulence (10%). Hypertension was observed in 60% of women, type 2 diabetes mellitus - in 24%. All patients had a genoid type of obesity. 34% of women with non-alcoholic liver steatosis were overweight, 29% were obese of the 1st degree, 23% were obese of the 2nd degree, and 14% of patients were obese of the 3rd degree. Conclusion: In the examined women with non-alcoholic liver steatosis in the early postmenopausal period living in Perm, risk factors for the development of obesity were identified: consumption of high-calorie foods with high fat and sugar content and hypokinesia, and the course of the disease was accompanied by the development of dyslipidemia, insulin and leptin resistance, inflammatory syndrome with activation of proinflammatory cytokine IL-6 and hyperfibrinogenemia, and also endothelial dysfunction, the severity of which increased during the transition from 1 to 2-3 degrees of obesity.

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Section: показатели контроль-бо-м насп-о-м рunclassified

Clinical and laboratory features of the course of non-alcoholic liver steatosis in women in the early postmenopausal period living on the territory of an industrial megapolis

Булатова

Shevlyukova

Sobol³

et al. 2023

jour

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“…Данные об эпидемиологии ЦП в России недостаточны и разрозненны. Согласно данным ФГБУ «НМИЦ терапии и профилактической медицины» Минздрава России фиброз и ЦП занимают 5-е место в структуре показателей потерянных лет потенциальной жизни (Potential Years of Life Lost -PYLL) у населения Российской Федерации в экономически активном возрасте (15-72 года) [5]. Причем в последние годы отмечается значительное увеличение вклада в заболеваемость фиброзом и ЦП неалкогольной жировой болезни печени [6,7].…”

Section: цирроз печени и его осложнения: актуальность проблемыunclassified

Liver cirrosis and complication risk management

Бакулин

Геннадьевич²,

Oganezova

et al. 2021

Terapevticheskii arkhiv

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Liver cirrhosis (LC) takes the main place in the structure of the pathology of the digestive system in terms of the frequency of mortality, as well as in the development of fatal and poorly controlled complications, which requires the search for effective methods for preventing the progression of the disease and the development of complications. The article provides updated information on the role of the intestinal microbiota, as well as endotoxemia and increased intestinal permeability syndromes in the pathophysiology of LC and its complications. The results of recent meta-analyses of the impact of dysbiotic disorders on the prognosis of the LC and the options for their correction are presented. Understanding of the significance of involvement of gut microbiota in the pathogenesis of LC has become one of the levers of management of the risks of complications of LC. In this case, the livergut axis can be considered to be the leading link to the formation of most of the main complications of LC.

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The activities of specialists in the field of health care organization and public health to manage the factors affecting the citizens’ life expectancy

Tregubov¹,

Bovina²

2021

Profil. med.

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The nosological structure of years of potential life lost in the economically active age in the Russian Federation in 2016

Cited by 5 publications

References 6 publications

Clinical and laboratory features of the course of non-alcoholic liver steatosis in women in the early postmenopausal period living on the territory of an industrial megapolis

Clinical and laboratory features of the course of non-alcoholic liver steatosis in women in the early postmenopausal period living on the territory of an industrial megapolis

Liver cirrosis and complication risk management

The activities of specialists in the field of health care organization and public health to manage the factors affecting the citizens’ life expectancy

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