The Novel Coronavirus – Latest Findings

Brüssow, Harald

doi:10.1111/1751-7915.13592

Cited by 6 publications

(5 citation statements)

References 91 publications

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“…This result is consistent with the research of Yang Yao in Shaanxi province outside Wuhan (12). In that study, the majority were mild cases (86.84%), and only 9.6% required a ventilator, far fewer than those reported in prior studies from the early stages of the COVID-19 pandemic (11), indicating that this disease has potentially become more mild as the chains of transmission have grown. However, the majority of COVID-19 cases, including those which are mild, can still quickly become severe or critical without medical support (13).…”

Section: Comparison Of Patient Characteristics In the Different Patiesupporting

confidence: 91%

“…The cases described herein were from the widespread national outbreak stage (9). In the current stage, no male dominance among the patients was evident, with fewer patients having been exposed to the Seafood Market (11). Furthermore, the mean age of COVID-19 patients presenting in the present study was 46.5 years.…”

Section: Comparison Of Patient Characteristics In the Different Patiementioning

confidence: 64%

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Clinical and Epidemiological Characteristics of COVID-19 Patients in Chongqing China

Yang

Qiu

Kong

et al. 2020

Front. Public Health

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Objectives: To study in-depth the clinical and epidemiological characteristics of pneumonia resulting from COVID-19 and provide evidence for effective public health decisions. Methods: This was a retrospective, single-center research study. Participants were enrolled from patients presenting at the Chongqing Public Health Medical Treatment Center from Jan 24 to Feb 7, 2020, and were confirmed as having COVID-19. Results: A total of 114 COVID-19 patients (99 mild, 4 severe, 11 critical) of which 56 (56/114; 49.1%) were male, 58 (58/114; 50.9%) were female with a mean age of 46.05 years. Twenty nine (29/114; 25.44%) patients suffered from chronic diseases. Neutrophils counts in 23.68% (27/114) of patients were abnormally low and abnormally high in 21.05% (24/114). Erythrocyte sedimentation rate and the C-reactive protein levels were abnormally elevated in 76.5% (62/81) and 62.9% (66/105) of patients, respectively. Creatine kinase isoenzymes (CK-MB), pro-brain natriuretic peptide (pro-BNP) and troponin levels were above the normal range in 7.10% (8/112), 66.7% (10/15), and 100% of patients, respectively. The percentage of patients in which the partial pressure of oxygen (PaO 2)/fraction of inspired O 2 (FiO 2) ratio exceeded 200 was 60%. A total of 91 (91/114; 79.82%) patients displayed severe bilateral pneumonia, 52 (52/114; 45.61%) exhibited ground-glass opacity, and pulmonary consolidation was observed in 4 (3.51%) patients. Differences in shortness of breath, insomnia, inappetence, the procalcitonin (PCT) levels, FiO 2 and PaO 2 /FiO 2 among the three groups were statistically significant (p < 0.05). Differences between the mild and severe groups was observed in neutrophil and lymphocyte counts, CD4 expression, and levels of C-reactive protein, alanine aminotransferase, aspartate aminotransferase and albumin (P < 0.05). Between the mild and critical groups, differences were observed in neutrophils, platelets, and CD4 expression (P < 0.05). A difference in C-reactive protein levels between severe and critical groups was also found (P < 0.05). Yang et al. SARS-CoV-2 and COVID-19 Patients Conclusions: In the majority of cases no gender differences were observed and mostly the symptoms were mild. Evidence of efficient human-to-human virus transmission was found. The elderly with comorbidities were more prone to develop into severe or critical illness. Age and comorbidity may be risk factors for poor outcome.

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Section: Comparison Of Patient Characteristics In the Different Patiesupporting

confidence: 91%

Section: Comparison Of Patient Characteristics In the Different Patiementioning

confidence: 64%

Clinical and Epidemiological Characteristics of COVID-19 Patients in Chongqing China

Yang

Qiu

Kong

et al. 2020

Front. Public Health

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“…The COVID‐19 pandemic has brought back into focus the global vulnerability of our society to infectious diseases (Brüssow, 2020). Among them, antimicrobial resistance (AMR) is currently one of the major global health concerns, with current predictions indicating that it will cause 10 million deaths annually by 2050 and a global cost of 100 trillion USD (Trotter et al ., 2019).…”

mentioning

confidence: 99%

Mining for novel antibiotics in the age of antimicrobial resistance

Udaondo

Matilla

2020

Microbial Biotechnology

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The misuse of antimicrobials is causing an alarming increase in the appearance of antibiotic-resistant microorganisms. In this context, the identification of novel antibiotics against new targets and with low rates of resistance development is a major global challenge. In this article, we highlight a number of recent articles that exploit a variety of in vitro, in vivo and in silico state-of-the-art approaches to identify and develop new antimicrobials. Rapid progress in this research field will be crucial to combating a global health problem, antimicrobial resistance, that is expected to be the leading cause of death by 2050.

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“…In China, the last part of 2019 has been characterized by the detection of a novel severe acute respiratory syndrome of unknown origin that did not respond to common treatments of respiratory illnesses. The causative agent of this rapidly-diffusing disease has been identified in an unknown coronavirus that has been denoted as SARS-CoV-2 (Brussow 2020 and references therein, Chen et al 2020). The unravelling of the virus genome has highlighted that SARS-CoV-2 shares remarkable similarities with the coronaviruses responsible for SARS and MERS syndromes, but also some clear distinctive features.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the time evolution of SARS-CoV-2 lethality rate in Italy: Evidence of an unaltered virus potency

Balasco

d’Alessandro

Smaldone

et al. 2020

Preprint

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In recent months, the entire world is facing a dramatic health emergency caused by the diffusion of a hitherto unknown coronavirus (SARS-CoV-2). Despite the efforts, the understanding of the many facets of the pandemic is still rather limited. In the present manuscript, we have monitored the evolution of the lethality rate in Italy by using the data collected over the last three months. Our data indicate that there is a striking correlation between the number of infected people of a certain week and the deaths of the following one. Despite the overall simplicity of the applied approach and its many approximations, the analysis of the Italian scenario provides some interesting insights into the pandemic. Indeed, we have found that the lethality rate is virtually unchanged over the last two months. This implies that the reduction of the deaths is strictly connected to the decrease of cases. Unfortunately, the present study does not support the idea that the virus potency has lowered in the last weeks, as our data demonstrate that the likelihood of a fatal outcome after the infection has not decreased in the recent outbreak evolution. Moreover, we show that the lethality rate is still very high in the country (≈13.5%). Since this number is remarkably higher if compared to the actual lethality estimates made worldwide, this finding suggests that the number of detected cases may be a gross underestimation of the actual infected people, likely due to the presence of a significant number of non-symptomatic or paucisymptomatic individuals in the population.

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The Novel Coronavirus – Latest Findings

Cited by 6 publications

References 91 publications

Clinical and Epidemiological Characteristics of COVID-19 Patients in Chongqing China

Clinical and Epidemiological Characteristics of COVID-19 Patients in Chongqing China

Mining for novel antibiotics in the age of antimicrobial resistance

Analysis of the time evolution of SARS-CoV-2 lethality rate in Italy: Evidence of an unaltered virus potency

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