The number of follicles and ovarian volume in the assessment of response to clomiphene citrate treatment in polycystic ovarian syndrome

Abstract

Small multiple follicles (> 9) and enlarged ovarian volume (> 6.8 ml) were the most prominent transvaginal ultrasonographic features of ovaries in Clomiphene Citrate nonresponsive patients with polycystic ovarian syndrome. Higher levels of Testosterone, luteinizing hormone and significantly higher number of small follicles were associated with lack of Clomiphene Citrate response. These ultrasonographic features and laboratory assays could be clinically useful for distinguishing better the Clomiphene Citrate nonresponders from responders.

Factors influencing ovarian response to tamoxifen in anovulatory patients

“…Other investigators have described parameters estimating ovarian response after treatment with clomiphene citrate [2–4]. In one study, greater mean ovarian volume and higher level of LH (which is shown as increased LH/FSH ratio) were associated with a lack of response to clomiphene citrate [3].…”

“…Other investigators have described parameters estimating ovarian response after treatment with clomiphene citrate [2–4]. In one study, greater mean ovarian volume and higher level of LH (which is shown as increased LH/FSH ratio) were associated with a lack of response to clomiphene citrate [3]. In another, hirsutism (as a manifestation of hyperandrogenemia) and elevated BMI were considered to be good markers predicting resistance to clomiphene citrate [4].…”