The Occurrence and Metabolism of Lanthanides

Evans, Christopher H.

doi:10.1007/978-1-4684-8748-0_7

Cited by 14 publications

(3 citation statements)

References 104 publications

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“…26,27 In fact, the impermeability of a number of other blood-tissue barriers to lanthanum has also been demonstrated, including the placenta and retina. 28,29 No functional or histopathological evidence of central nervous system toxicity of lanthanum has been identified in oral or intravenous studies with lanthanum carbonate in animals (Damment SJP, Greaves P, Downes N, Presented at the 36th Annual Meeting of the American Society of Nephrology, San Diego, CA, USA, 2003; Jones C, Webster I, Damment SJP, Presented at the 19th Congress of the ERA-EDTA, Lisbon, Portugal, 2004). Although brain lanthanum deposition has been reported recently in an animal model of renal failure, 30 this finding has been challenged as a contamination artifact, 31 as the mode of administration chosen (diet admixture) carried a high risk of sample contamination during autopsy.…”

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confidence: 99%

Cognitive function in Stage 5 chronic kidney disease patients on hemodialysis: No adverse effects of lanthanum carbonate compared with standard phosphate-binder therapy

Altmann

Barnett

Finn

2007

Kidney International

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Patients with Stage 5 chronic kidney disease who have hyperphosphatemia require treatment with phosphate binders to lower serum phosphorus levels. Existing binders are effective but may be associated with important safety disadvantages. Lanthanum carbonate is a phosphate binder with demonstrated efficacy, safety, and tolerability in clinical trials. Changes in cognitive function were evaluated over time using the Cognitive Drug Research computerized cognitive assessment system (Simple Reaction Time, Digit Vigilance Task, Choice Reaction Time, Numeric Working Memory, and Delayed Picture Recognition) in 360 hemodialysis patients who were enrolled in a 2-year, multicenter, comparative study of lanthanum carbonate versus standard therapy. A decline in cognitive function from baseline was observed in both groups. The deterioration in cognitive function was similar in both the lanthanum carbonate and standard therapy groups. One parameter - Numeric Working Memory - showed a statistically significant between-group difference in favor of lanthanum carbonate (P=0.02). Given the magnitude of the changes, however, and the differences that were observed at baseline between treatment groups, the clinical significance of this difference is doubtful. This study demonstrates that cognitive function deteriorates in hemodialysis patients over a 2-year time period. Use of lanthanum carbonate as a phosphate binder does not adversely affect cognitive function compared with standard therapy.

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mentioning

confidence: 99%

Cognitive function in Stage 5 chronic kidney disease patients on hemodialysis: No adverse effects of lanthanum carbonate compared with standard phosphate-binder therapy

Altmann

Barnett

Finn

2007

Kidney International

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“…In our study, we employed the typical way of making the extraction solutions by allowing the alloys to be immersed in a basal medium. However, this could be insufficient considering the tendencies of REEs to form compounds or participation with constituents of the culture media or physiological fluids ( Evans and Evans, 1990 ). This resulted in divergent ranges of toxicity when interpreting the toxicities of REEs in correlation with their solubilities ( Wald, 1989 ; Pagano et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of extract solution from magnesium alloys supplemented with different compositions of rare earth elements on in vitro epithelial and osteoblast progenitor cells

Nie

Chen

Liu³

et al. 2023

Front. Bioeng. Biotechnol.

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Background: Magnesium alloys (Mg-alloys) have been widely researched in recent years to serve clinically as a promising bioactive material. Supplementation with rare earth elements (REEs) has been of particular interest due to their contributions to mechanical properties and potential involvement in biological processes.Methods: In this study, two culture systems were used: human umbilical vein endothelial cells and mouse osteoblastic progenitor cells. The effects of the extract solution from different compositions of Mg-alloys containing gadolinium (Gd), dysprosium (Dy), and yttrium (Y) were evaluated through observation of cell proliferation, viability, and specific cell functions.Results: Within the range of weight percentages, these Mg-REE alloys did not show appreciable negative impacts on either cell line. Interestingly, moderate compositions (Mg-1.5Gd-1.5Dy-0.825Y-0.5Zr and Mg-2Gd-2Dy-1.1Y-0.5Zr) tended to enhance the osteoblastic activity and promote the vascularization process, providing insights into further explorations for optimizing compositions of REEs in novel Mg alloys.

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“…There is no recognized plausible biological mechanism to explain this inverse association. Scandium can affect the activity of several enzymes (Evans, 1990) and can behave as calcium under certain circumstances (Frausto da Silva and Williams, 1991). Horovitz (2000) suggests that scandium may substitute for several elements that have well-established physiological functions and thereby exert beneficial or essential trace metal effects.…”

Section: Discussionmentioning

confidence: 99%

Association between toenail scandium levels and risk of acute myocardial infarction in European men: the EURAMIC and Heavy Metals Study

et al. 2002

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The association between scandium status and risk of acute myocardial infarction (MI) was examined in a multicentre case control study in 10 centres from Europe and Israel. Scandium in toenails was assessed in 684 cases and 724 controls less than 70 years of age. Mean concentrations of toenail scandium were 6.74 micro/kg in cases and 7.75 microg/kg in controls. Scandium among controls, adjusted for age and centre was positively associated with concentrations of lycopene and oleic acid in adipose tissue (P = 0.002 for both nutrients). Pearson correlations adjusted for age and centre were significant (P < 0.05) between scandium and lycopene (r = 0.08), zinc (r = 0.08), mercury (r = 0.18) and oleic acid (r = 0.21). Overall, cases had lower levels of scandium than controls after adjustment for age and centre (case control ratio, 0.87; 95% CI 0.79-0.96). This association persisted after adjustment for other cardiovascular risk factors (case-control ratio 0.88; 95% CI, 0.79-0.98). The risk of MI at high scandium levels was reduced after adjustment for age and centre (P-trend = 0.04). Further adjustments for BMI, history of hypertension, smoking, alcohol intake, diabetes, family history of CHD, alpha-tocopherol, beta-carotene, lycopene, selenium and mercury slightly attenuated this trend (P = 0.055). Our results suggest that toenail scandium level is associated with a reduced risk of acute MI, but we are uncertain whether this element can really play a protective role in the development of CHD. Without an identified plausible mechanism, these results should be regarded as preliminary and should be tested in future studies.

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The Occurrence and Metabolism of Lanthanides

Cited by 14 publications

References 104 publications

Cognitive function in Stage 5 chronic kidney disease patients on hemodialysis: No adverse effects of lanthanum carbonate compared with standard phosphate-binder therapy

Cognitive function in Stage 5 chronic kidney disease patients on hemodialysis: No adverse effects of lanthanum carbonate compared with standard phosphate-binder therapy

Effects of extract solution from magnesium alloys supplemented with different compositions of rare earth elements on in vitro epithelial and osteoblast progenitor cells

Association between toenail scandium levels and risk of acute myocardial infarction in European men: the EURAMIC and Heavy Metals Study

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