The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling

Dong, Lixue; Yang, Guosheng; Pan, Yu-Fei; Chen, Yao; Tan, Ye-Xiong; Dai, Rongyang; Ren, Yibin; Fu, Jing; Wang, Hongyang

doi:10.1038/cr.2011.103

Cited by 45 publications

(27 citation statements)

References 40 publications

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“…It has been previously reported that Gankyrin regulates transcription indirectly through NFkB and Wnt signaling pathways (2,17). To identify the transcriptional targets of Gankyrin, we conducted genome-wide screening using SW480 cells with Gankyrin knockdown on an Affymetrix gene expression array, which identified 937 genes that were differentially regulated by Gankyrin knockdown (1.5-fold, P < 0.05).…”

Section: Il-8 Signaling Pathway Is Regulated By Gankyrin In Crc Cellsmentioning

confidence: 99%

“…Overexpression of Gankyrin induces cyclin D1 protein expression in hepatic carcinoma (17). To test whether Gankyrin requires Cyclin D1 in promoting cell migration, we overexpressed Gankyrin in 3T3 fibroblast derived from Ccnd þ/þ and Ccnd À/À mice (30).…”

Section: Gankyrin Promotes Colorectal Cell Migration Through Targetinmentioning

confidence: 99%

“…(v) Gankyrin mediates Ras-induced tumorigenesis by suppressing ROCK activity (16), and (vi) Gankyrin enhances PI3K/AKT/HIFa signaling pathway in hepatocellular carcinoma (HCC; refs. [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Gankyrin Activates IL-8 to Promote Hepatic Metastasis of Colorectal Cancer

Bai

Tai

et al. 2013

Cancer Research

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Hepatic metastasis is responsible for the majority of colorectal cancer (CRC)-related mortalities. Although Gankyrin (PSMD10) has been implicated in cancer metastasis, its exact role and underlying mechanisms of CRC hepatic metastasis remain largely unknown. Herein, we showed that the expression of Gankyrin was higher in primary CRC with hepatic metastasis compared with CRC without metastasis. RNAi-mediated silencing of Gankyrin expression in highly metastatic human CRC cells impaired their migratory and metastatic capacity in vivo. Genome-wide transcriptome profiling revealed activation of the interleukin (IL)-8 signaling pathway by Gankyrin. Protein levels of IL-8 and cyclin D1 (CCND1), the two important molecules in the IL-8 pathway, were positively correlated with Gankyrin expression in human CRC specimens. Furthermore, genetic deletion of cyclin D1 showed its requirement in Gankyrin-mediated cell migration. Finally, administration of recombinant IL-8 rescued the migratory defect of CRC cells where Gankyrin expression was silenced. Together, our findings highlight the importance of Gankyrin in hepatic metastasis of CRC and point out its candidature as a potential prognostic marker and therapeutic target to improve the clinical management of metastatic CRC. Cancer Res; 73(14); 4548-58. Ó2013 AACR.

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Section: Il-8 Signaling Pathway Is Regulated By Gankyrin In Crc Cellsmentioning

confidence: 99%

Section: Gankyrin Promotes Colorectal Cell Migration Through Targetinmentioning

confidence: 99%

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Gankyrin Activates IL-8 to Promote Hepatic Metastasis of Colorectal Cancer

Bai

Tai

et al. 2013

Cancer Research

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“…101 Enforced expression of PSMD10 in hepatoma cells promoted dedifferentiation and also increased CD133 expression. 102 Regulation of PSMD10 transcription is activated by β-catenin and c-myc, 103 in addition to the general transcription panel members regulating other proteasome units expression, such as NRF2. 104 PSMD10 is a ubiquitin receptor and is involved in facilitation of degradation of both tumor suppressors p53 and Rb by the proteasome.…”

Section: Rbx1mentioning

confidence: 99%

Proteasome expression and activity in cancer and cancer stem cells

Voutsadakis

2017

Tumour Biol.

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Proteasome is a multi-protein organelle that participates in cellular proteostasis by destroying damaged or short-lived proteins in an organized manner guided by the ubiquitination signal. By being in a central place in the cellular protein complement homeostasis, proteasome is involved in virtually all cell processes including decisions on cell survival or death, cell cycle, and differentiation. These processes are important also in cancer, and thus, the proteasome is an important regulator of carcinogenesis. Cancers include a variety of cells which, according to the cancer stem cell theory, descend from a small percentage of cancer stem cells, alternatively termed tumor-initiating cells. These cells constitute the subsets that have the ability to propagate the whole variety of cancer and repopulate tumors after cytostatic therapies. Proteasome plays a role in cellular processes in cancer stem cells, but it has been found to have a decreased function in them compared to the rest of cancer cells. This article will discuss the transcriptional regulation of proteasome sub-unit proteins in cancer and in particular cancer stem cells and the relationship of the proteasome with the pluripotency that is the defining characteristic of stem cells. Therapeutic opportunities that present from the understanding of the proteasome role will also be discussed.

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“…Prof. Yan [10] reported the role of T cells in skin inflammation, Shao and Qian [11,12] have investigated the mechanisms of infections, Profs. Wang and Li have investigated the role of Wnt/β-catenin signaling in diseases [13,14]. Also researchers have made progress in elucidating mechanisms of development of tumorigenesis of lung cancer, breast cancer and colon cancer [13,15,16].…”

mentioning

confidence: 99%