2011
DOI: 10.1016/j.bios.2011.04.034
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The open container-used microfluidic chip using IrOx ultramicroelectrodes for the in situ measurement of extracellular acidification

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Cited by 13 publications
(12 citation statements)
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“…On the other side, in disagreement with the grain-boundaries model, the use of argon-based plasma was found to be responsible for complex resistivity variations with film thickness due to huge discrepancies in terms of microstructure, morphology and porosity [46]. [14][15][16][17][18][24][25][26][27]. It should be mentioned that literature showed supra-Nernstian pH responses for AEIROF-based microelectrodes and related them to variations in the IrO2 oxidation state [12,19,20,22,23,25].…”
Section: Deposition Of Tungsten Thin Filmsmentioning
confidence: 95%
See 1 more Smart Citation
“…On the other side, in disagreement with the grain-boundaries model, the use of argon-based plasma was found to be responsible for complex resistivity variations with film thickness due to huge discrepancies in terms of microstructure, morphology and porosity [46]. [14][15][16][17][18][24][25][26][27]. It should be mentioned that literature showed supra-Nernstian pH responses for AEIROF-based microelectrodes and related them to variations in the IrO2 oxidation state [12,19,20,22,23,25].…”
Section: Deposition Of Tungsten Thin Filmsmentioning
confidence: 95%
“…As a result, these anodically electrodeposited iridium oxide films (AEIROF) were used for various pH-related applications: pH sensing [14,15,18], pH imaging using scanning electrochemical microscopy [19], biomedical analysis [20], neurostimulation [21], cell media microanalysis [22]. Nevertheless, even if first devices were reported for simultaneous fabrication of AEIROF-based microelectrodes into microfluidic channels [22][23][24], the integration of IrOx-based pH microsensors is still hindered by low compatibility of anodic electrodeposition with mass fabrication. In order to overcome these limitations, some technological processes were proposed, including thermal oxidation [25], physical vapour deposition [26,27] and sol-gel dipcoating/patterning deposition [28,29].…”
Section: Introductionmentioning
confidence: 99%
“…With the production of their respective by-products (e.g., H 2 O 2 ), the enzyme (e.g., oxidase enzyme) oxidizes or reduces the analytes at a properly polarized electrode (e.g., platinum) [28]. Several attempts to incorporate pH and oxygen optical sensing systems and optical sensors for glucose and lactate into microfluidic platforms have been proposed [79,105,106,107,108,109,110,111]. In this framework, a microfluidic glass chip has been fabricated by combining cell culture and metabolic monitoring equipment with fully integrated biosensors.…”
Section: Development Of Long-term Testing In Moc Systemsmentioning
confidence: 99%
“…Cells can be cultured in a tiny space and their physiological and electrical responses will be captured easily. Currently, many researches are covered in analyzing extracellular microenvironment [ 173 ] and intracellular components [ 174 ], monitoring ligand-induced cell secretion [ 175 ], recording the extracellular potential [ 176 ] and cell dynamic responses [ 177 , 178 ], etc . Besides, the cell patterning technique is an important issue in fundamental cell biology, tissue engineering, and neuron network research.…”
Section: Development Trends Of Electrochemical Cell-based Biosensomentioning
confidence: 99%