The Origin of Cholesterol’s Condensing Effect

Daly, Trevor A.; Wang, Minghui; Regen, Steven L.

doi:10.1021/la105039q

Cited by 57 publications

(86 citation statements)

References 20 publications

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“…Similar results were also obtained when the properties of cholesterol versus cholestanol (dihydrocholesterol) in bilayers were compared [24,25].…”

Section: Comparison Between the Effect Of B-sitostanol And B-sitosterolsupporting

confidence: 68%

“…In the studies on the domainpromoting ability of cholesterol and its derivatives in phospholipid bilayers, was evidenced that both cholesterol and cholestanol (dihydrocholesterol) promote domains formation in a similar way and both compounds are of similar packing properties [24]. Similarities of condensing properties for cholesterol and cholestanol (dihydrocholesterol) were also found in DPPC and DPPC/DPPG liposomes [25]. Our intention is to compare the effect of plant sterol (b-sitosterol) and the corresponding stanol (b-sitostanol) on various membrane phospholipids.…”

Section: Introductionmentioning

confidence: 90%

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The influence of plant stanol on phospholipids monolayers – The effect of phospholipid structure

Hąc-Wydro

Zając

Dynarowicz-Łątka

2011

Journal of Colloid and Interface Science

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“…Similar results were also obtained when the properties of cholesterol versus cholestanol (dihydrocholesterol) in bilayers were compared [24,25].…”

Section: Comparison Between the Effect Of B-sitostanol And B-sitosterolsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 90%

The influence of plant stanol on phospholipids monolayers – The effect of phospholipid structure

Hąc-Wydro

Zając

Dynarowicz-Łątka

2011

Journal of Colloid and Interface Science

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“…Ceramide EOS was found to stabilize the OR phases [94]. The location and the mechanism of action of cholesterol in vivo, just like in phospholipids membranes, are still not fully understood [95][96][97]. It is not clear how the cholesterol molecules are distributed between the phases.…”

Section: Lateral Organizationmentioning

confidence: 99%

The physical chemistry of the stratum corneum lipids

Boncheva

2014

Intern J of Cosmetic Sci

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SynopsisThe extracellular matrix of stratum corneum (SC) participates actively in the defensive performance of human skin. Understanding its physicochemical properties is essential for understanding the skin homoeostasis, for the development of efficient therapies for skin disorders and diseases and for ensuring the safety of products designed for topical application. This article summarizes the current knowledge of the composition, self-assembly and molecular organization of the SC lipids, reviews the evidence connecting these parameters and the barrier properties of human skin, and outlines the immediate issues in the field of SC lipid research. R ESUM E: La matrice extracellulaire du stratum corneum (SC) participe activement a la performance d efensive de la peau humaine. Comprendre ses propri et es physico-chimiques est essentielle pour comprendre l'hom eostasie de la peau, pour le d eveloppement de th erapies efficaces pour les troubles et les maladies de la peau, et pour assurer la s ecurit e des produits conc ßus pour une application topique. Cet article r esume les connaissances actuelles sur la composition, l'auto-assemblage, et l'organisation mol eculaire des lipides SC, examine les preuves reliant ces param etres et les propri et es de barri ere de la peau humaine, et d ecrit les probl emes imm ediats dans le domaine de la recherche sur les lipides SC. IntroductionThe field of skin research is replete with opportunities for those intent on working on scientifically interesting topics while making a noticeable, positive difference in people's lives [1]. The range of important problems that the field can help solving is broad. It comprises (i) reducing infant mortality, especially in the developing countries where defective skin barrier is the second major cause of preterm mortality [2][3][4][5][6]; (ii) improving the skin health of some 20-30% of the population in the developed countries which suffer from some sort of skin barrier dysfunction [7,8]; (iii) developing efficient strategies for the dermal and transdermal delivery of drugs and vaccines [9]; (iv) increasing the national and personal security by developing methods to retard or prevent the skin penetration of chemical warfare agents, toxic spills and pesticides [10, 11]; (v) enhancing the safety of topical products (e.g. fragrances, cosmetics, cleansing agents, sunscreens and insect repellents) [12]. Thus, the targets in skin research cover the full spectrum from counter-acting leaky skin and preventing its penetration by chemicals to pushing chemicals through it. One common major problem underlies these diverse topics: our insufficient understanding of the factors that determine skin permeability.Understanding the permeability of human skin to a large extent means understanding the extracellular lipid matrix of the stratum corneum (SC), the topmost skin layer which constitutes the main barrier to transdermal fluxes [13][14][15][16][17][18][19]. As the lipid matrix forms an uninterrupted pathway from the skin surface to the viable skin tissu...

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“…The rigid nucleus of cholesterol has been suggested to play an important role in the condensing effect of cholesterol on a fluidic monolayer 48 . The rigid nucleus of cholesterol would maximize the hydrocarbon chain contact with neighboring molecules 49 . Thus cholesterol drove the condensation of hydrocarbon chains and induced a more conformational order of the hydrocarbon chains, resulting in the cholesterol-induced condensing effect accompanying with the ordering effect on the monolayers at a LE state.…”

Section: Ra Anγ Bmentioning

confidence: 99%