The Oxidant Effect of Bisphenol A (BPA) Can be Decoupled from its Endocrine Disruptor Property

Abstract

Bisphenol A (BPA) is an environmental defilement released mainly from polycarbonate plastic and epoxy resins. The main toxicological impact of BPA is its endocrine disruptor activities. Its structural features confer the ability to bind to both estrogen receptor (ER) subtypes. Furthermore, we recently reported that BPA aggravates male reproductive hormones. In addition to its endocrine disruptor properties, we have also reported that BPA possesses oxidant activity which is able to trigger oxidative stress. Several types of research previously reported that oxidative stress may cause hormonal imbalance and vice versa. However, the relation of both the toxicological properties of BPA is poorly understood. In this study, we found that oral testosterone undecanoate treatment in BPA-induced rats does not prevent decreasing serum superoxide dismutase, glutathione peroxidase, and catalase, and increasing serum malondialdehyde. Oral N-acetyl cysteine (NAC) in BPA-induced rats also does not attenuate decreasing total testosterone levels. These results suggest that the oxidant effect and endocrine disruptor property of BPA can be separated and might not interfere with one another. Therefore, future treatment in any pathological condition resulting from BPA exposure has to be carried out with more comprehensive approaches rather than focusing on its endocrine disruptor activity.

Angelica keiskeileaves extract attenuates psychosocial stress in overcrowding-subjected rats

“…In the present study, MDA and SOD were used as oxidative stress markers. MDA is produced as a byproduct of lipid peroxidation, and SOD acts as a radical scavenger by catalyzing the dismutation of the superoxide anion radical into non-reactive molecules [46,47]. Studies showed that the animal model of psychosocial stress exhibits elevated MDA levels and reduced levels of SOD in the brain tissue [48], causing the depletion of 5-HT levels and triggering anxiety- and depressive-related behaviors, as evidenced by the open field and forced swim tests.…”

Bisphenol A Meningkatkan Malondialdehid dan Indeks Apoptosis Hati Tikus (Rattus norvegicus) Jantan

“…Bisphenol-A merupakan salah satu senyawa endocrine disruptors yang dapat mengganggu biosintesis, sekresi, kerja atau metabolisme hormon endogen (Sipahutar et al, 2007). Selain sebagai endocrine disruptors, disebutkan bahwa BPA juga menyebabkan peningkatan senyawa radikal di dalam tubuh dan menginduksi terjadinya stres oksidatif (Wisesa et al, 2020). Asahi et al (2010) dan Moon et al (2012) melaporkan bahwa BPA meningkatkan produksi reactive oxygen species (ROS), dan menyebabkan disfungsi mitokondria.…”

“…Toksisitas BPA selama ini hanya difokuskan efeknya pada sistem reproduksi (Chitra et al, 2003;Aydoðan dan Barlas, 2006). Namun, penelitian terbaru mengemukakan bahwa BPA juga menyebabkan stres oksidatif, dan efek stres oksidatif BPA ini bersifat independen terhadap efek toksiknya pada sistem reproduksi (Wisesa et al, 2020). Bisphenol A juga menyebabkan stres oksidatif pada organ vital manusia (Asahi et al, 2010;Moon et al, 2012).…”

Preparation of a Novel Resin Based Covalent Framework Material and Its Application in the Determination of Phenolic Endocrine Disruptors in Beverages by SPE-HPLC

“…Among them, bisphenol A (BPA) and bisphenol F (BPF), as important intermediates, are mostly used in the production of polycarbonate plastics and epoxy resins, ref. [ 3 , 4 , 5 , 6 ] while nonylphenol (NP) and octyl phenol (OP) are widely used in the production of plastic bags, plasticizers, detergents, pesticides, etc [ 7 , 8 , 9 , 10 ]. These EDCs widely exist in the environment, causing potential harm to human health [ 11 , 12 ], and the amount of these disruptors is very small in environmental samples.…”