The Pathogenesis of Uræmia in Acute Renal Failure Abnormality of Intrarenal Vascular Tone as Possible Mechanism

Finckh, E.S.

doi:10.1016/s0140-6736(62)90112-5

Cited by 26 publications

(5 citation statements)

References 48 publications

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“…The diminution or cessation of glomerular filtration in acute renal failure caused by both mercury and glycerol is probably the result of altered glomerular afferent-efferent arteriolar tone (8,14), a mechanism postulated by others in a variety of renal failure models (4,5,7,10,19,22). Direct evidence for such a mechanism in methemoglobin induced acute renal failure has been published recently by Ruiz-G u in a zu et al (17).…”

Section: Discussionmentioning

confidence: 93%

The Role of the Concentration Mechanism in the Development of Acute Renal Failure: Micropuncture Studies Using Diabetes Insipidus Rats

Wilson

Thiel

Arce

et al. 1969

Nephron

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The role of the concentrating mechanism in the potentiation of acute renal failure by dehydration has been studied using rats with complete diabetes insipidus. These rats were shown to be continually dehydrated even when allowed free access to water. Despite massive volumes of highly dilute urine at the time that hemoglobinuria was induced by glycerol injection, these animals developed acute renal insufficiency whose severity was intermediate between that of non-dehydrated and severely dehydrated normal rats treated similarly. Micropuncture experiments showed the appearance of the kidney in vivo and the functional abnormalities of the three types of rats to be qualitatively identical. It appears that dehydration’s effect on hemoglobinuric acute renal failure is independent of the concentrating mechanism and correlates well with plasma volume depletion. It is suggested that factors other than ADH titre, high urine concentration and low flow rate are the prime determinants of the effect of dehydration on hemoglobinuric acute renal failure in the rat.

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Section: Discussionmentioning

confidence: 93%

The Role of the Concentration Mechanism in the Development of Acute Renal Failure: Micropuncture Studies Using Diabetes Insipidus Rats

Wilson

Thiel

Arce

et al. 1969

Nephron

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“…G ó m o r i has shown by injection studies and clearance techniques that water and electrolyte depletion in the dog results in areas of nonperfused cortical tissue, decreased extraction o f PAH and decreased glomerular filtration rate out o f proportion to the changes in renal blood flow (32). Comparable mechanisms have been postulated by others (7,13,27,29,57,60). Micropuncture studies in this laboratory (55) also indicate that changes in renal vascular tone probably are responsible for cessation or gross diminution o f glomerular filtration in glycerol-induced hemoglobinuric acute renal failure.…”

Section: Discussionmentioning

confidence: 52%

Glycerol Induced Hemoglobinuric Acute Renal Failure in the Rat

Thiel

Wilson

Arce

et al. 1967

Nephron

121

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Hemoglobinuric acute renal failure occurs consistently in rats deprived of water for 24 h and injected with 50% glycerol solution (10 ml/kg) intramuscularly. Severe azotemia developed in 33% of non-dehydrated rats receiving glycerol but 44% were not azotemic, thus permitting a study of the factors which predispose to the development of acute renal failure. There was no necessary correlation between urine volume, urine osmolality, or plasma volume before injection and the development of oliguric acute renal failure, nor was the urine pH during hemoglobinuria correlated with the subsequent severity of azotemia. Plasma volume depletion was the only major difference detected between dehydrated rats which universally developed severe acute renal failure and non-dehydrated rats which were frequently spared. Small differences in plasma volume did not appear to alter the severity of renal involvement in non-dehydrated rats, however.

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“…The persistently raised blood urea and slow return of renal function probably was due to residual vasomotor disturbance. (Finckh, 1962;Finckh, Jeremy and Whyte, 1962).…”

Section: Case Historiesmentioning

confidence: 99%