The pathophysiology of osteoarthritis

Ashkavand, Zahra; Malekinejad, Hassan; Vishwanath, Bannikuppe S.

doi:10.1016/j.jopr.2013.01.008

Cited by 48 publications

(59 citation statements)

References 88 publications

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“…Mechanisms suspected to cause joint damage are not known, but joint damage may occur multifactorially including oxidative damage, cartilage thinning, muscle weakening, and proprioceptive weakness (Palazzo et al, 2016). Increased age causes the tension properties of the cartilage to decrease resulting in an accumulation of glycation that causes mechanical failure (Ashkavand et al, 2013). The body's ability to repair cartilage also decreases with age (Simon, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Demographic Profile, Clinical and Analysis of Osteoarthritis Patients in Surabaya

Ahmad

Rahmawati²,

Wardhana³

2018

BHSJ

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Introduction: Osteoarthritis is a degenerative joint disease which affects joint cartilage. As many as 80% patients movement are limited and 25% of them can not even perform daily activities. Osteoarthritis is one of the ten most disabling diseases in developed countries. Due to its chronic and progressive nature, socio-economic impacts in many developed and developing countries are enormous. The purpose of this study is to determine the profile of patients with osteoarthritis in the Orthopedic Department of RSUD Dr. Soetomo Surabaya (Dr. Soetomo General Hospital)Method: This is descriptive observasional research. Questionnaires data were obtained from all patients in the Department of Trauma and Orthopedic of RSUD Dr. Soetomo Surabaya during September 1, 2016 until October 31, 2016. Thirty five subjects with osteoarthritis were analyzed for the study. The variables observed in the patient profile include sex, age, body mass index, type of osteoarthritis, Kellgren-Lawrence scoring system, and knee osteoarthritis severity index.Result: The result shows that 43% of the samples were aged 60-69 years, 83% of the samples were female, 37% of the samples had an I BMI obesity, 60% of samples had bilateral osteoarthritis, and 77% of samples from primary osteoarthritis. A total of 15 of 53 knee samples had class III, and 15 of 53 knee samples also had class I, and as many as 21 of the 35 samples had a "very severe" clinical gradation. These results may be due to patients who have low grade gradation clinics and have received medical attention at the level I health facility or II.Conclusion: From the results of this study, it can be concluded that age, sex, BMI, Kellgren-Lawrence assessment system, index severity of patients Lequesne osteoarthritis in RSUD Dr. Soetomo Surabaya is in conformity with research that has been done in many places and theories that exist.Keywords: Knee osteoarthritis, age, gender, Kellgren-Lawrnce scoring system, knee osteoarthritis severity index

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Section: Discussionmentioning

confidence: 99%

“…Research shows that obesity has a positive relationship with osteoarthritis genu (Ashkavand et al, 2013) Obesity also accelerates the progression of osteoarthritis when the damage has started. This is because in people with obesity, joints must withstand heavier loads so that increase damage risk (Simon, 2012).…”

Section: Discussionmentioning

confidence: 99%

Demographic Profile, Clinical and Analysis of Osteoarthritis Patients in Surabaya

Ahmad

Rahmawati²,

Wardhana³

2018

BHSJ

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“…It is characterized by progressive destruction of the articular cartilage and substantial abnormalities in the subchondral bone, ligaments, synovial membrane, articular capsule, and periarticular muscles. OA can be triggered by various factors like inflammation, physical injury, and other metabolic causes [2]. A number of environmental risk factors such as obesity and trauma can also initiate diverse pathological pathways which may eventually lead to OA [3].…”

Section: Introductionmentioning

confidence: 99%

Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis

2018

J Orthop Surg Res

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BackgroundThe measurement of cartilage oligomeric matrix protein (COMP) has become a novel way for the diagnosis of knee osteoarthritis (OA). However, no conclusive correlation has been drawn between COMP and knee OA. The purpose of this study was to examine the utility of serum COMP as biomarker for knee OA and its relation with disease severity.MethodsA systematic search on PubMed, ScienceDirect, and EMBASE was conducted in January 2018 using certain keywords. Initial search yielded a total of 285 publications, and 35 articles were reviewed in full-text. Eventually, nine studies were included in the analysis. All the retrieved studies used Kellgren-Lawrence (K-L) classification for knee OA and provided available data of serum COMP in OA patients and healthy controls. Sensitivity analysis was performed by removing one study result at a time to detect the impact of each study have on the overall effect and to test the stability of the cumulative result. Subgroup study based on K-L grade system was also conducted to disclose the correlation between serum COMP and knee OA disease severity.ResultsPooled analysis of nine studies demonstrated a significant elevation of serum COMP in knee OA patients (SMD 0.81, [95% CI, 0.36, 1.25], P = 0.0004) compared with controls. In comparisons between K-L 1–4 and controls, significantly higher serum COMP was detected in all three subgroups except K-L grade 1 versus control. Comparisons among K-L grades 1–4 revealed significantly higher serum COMP levels in patients with more serious than less serious disease stage. However, the elevation in patients with K-L grade 3 did not reach statistical significance when compared with K-L grade 1 patients.ConclusionThe overall analysis showed significantly higher serum COMP in knee OA patients compared to controls which indicate the potential ability of serum COMP in differentiating knee OA patients from healthy subjects. Pooled statistic of our meta-analysis showed that serum COMP levels were effective in distinguishing patients with K-L ≥ 2.

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“…Osteoarthritis (OA) is a chronic inflammatory joint disease that frequently coexists with other comorbidities, reducing joint range of motion and generating pain, functional limitations, and a high economic burden. 1 – 3 Although there are some partially effective methods, 4 it is generally accepted that treatments do not completely prevent disease progression, 3 which is associated with cartilage erosion and joint inflammation, leading to disability. 1 …”

Section: Introductionmentioning

confidence: 99%

Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression

Calvo

Sánchez-Herraéz

Casis

et al. 2020

Bone & Joint Research

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Aims To analyze the potential role of synovial fluid peptidase activity as a measure of disease burden and predictive biomarker of progression in knee osteoarthritis (KOA). Methods A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years (SD 1.15) with advanced KOA (Ahlbäck grade ≥ 3 and clinical indications for arthrocentesis) recruited through the (Orthopaedic Department at the Complejo Asistencial Universitario de León, Spain (CAULE)), measuring synovial fluid levels of puromycin-sensitive aminopeptidase (PSA), neutral aminopeptidase (NAP), aminopeptidase B (APB), prolyl endopeptidase (PEP), aspartate aminopeptidase (ASP), glutamyl aminopeptidase (GLU) and pyroglutamyl aminopeptidase (PGAP). Results Synovial fluid peptidase activity varied significantly as a function of clinical signs, with differences in levels of PEP (p = 0.020), ASP (p < 0.001), and PGAP (p = 0. 003) associated with knee locking, PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p = 0.000) with knee failure, and PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p < 0.001) with knee effusion. Further, patients with the greatest functional impairment had significantly higher levels of APB (p = 0.005), PEP (p = 0.005), ASP (p = 0.006), GLU (p = 0.020), and PGAP (p < 0.001) activity, though not of NAP or PSA, indicating local alterations in the renin-angiotensin system. A binary logistic regression model showed that PSA was protective (p = 0.005; Exp (B) 0.949), whereas PEP (p = 0.005) and GLU were risk factors (p = 0.012). Conclusion These results suggest synovial fluid peptidase activity could play a role as a measure of disease burden and predictive biomarker of progression in KOA. Cite this article: Bone Joint Res 2020;9(11):789–797.

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The pathophysiology of osteoarthritis

Cited by 48 publications

References 88 publications

Demographic Profile, Clinical and Analysis of Osteoarthritis Patients in Surabaya

Demographic Profile, Clinical and Analysis of Osteoarthritis Patients in Surabaya

Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis

Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression

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