The pathways connecting the hippocampal formation, the thalamic reuniens nucleus and the thalamic reticular nucleus in the rat

Çavdar, Safiye; Onat, Filiz; Çakmak, Yusuf; Yananlı, Hasan Raci; Gulcebi, Medine I.; Aker, Rezzan

doi:10.1111/j.1469-7580.2008.00858.x

Cited by 72 publications

(45 citation statements)

References 47 publications

(77 reference statements)

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“…Taken together, these data suggest that interactions of the PFC system with TRN may be critical in complex situations such as emotional reactivity. Finally, in accordance with our results, a recent report demonstrates projections from the hippocampal formation to the rostral TRN in the rat and also shows that the same sector of the TRN receives input from the reuniens nucleus of the thalamus (Cavdar et al, 2008). Therefore, lesion of the TRN may in part alter the thalamic-hippocampal circuitry, such as our results suggest.…”

Section: Damage Of the Trn Induced Neuronal Hypotrophy In Pfc Ventrasupporting

confidence: 93%

Dendritic morphology changes in neurons from the prefrontal cortex, hippocampus and nucleus accumbens in rats after lesion of the thalamic reticular nucleus

et al. 2012

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Section: Damage Of the Trn Induced Neuronal Hypotrophy In Pfc Ventrasupporting

confidence: 93%

Dendritic morphology changes in neurons from the prefrontal cortex, hippocampus and nucleus accumbens in rats after lesion of the thalamic reticular nucleus

et al. 2012

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“…This apparent neglect is surprising given the connections between the ReRh and brain structures such as the hippocampus and medial prefrontal cortex (mPFC), which are both crucial to memory processing over time (Frankland and Bontempi, 2005;Sutherland et al, 2010;Winocur et al, 2010). Indeed, the ReRh is the major source of excitatory thalamic projections to the hippocampus (Wouterlood et al, 1990; Dolleman-Van der Weel et al, 1997; Bertram and Zhang, 1999;Cavdar et al, 2008), and has dense bilateral connections with the PFC (Vertes, 2002;Vertes et al, 2006; Hoover and c-Fos immunohistochemistry Brain preparation and section processing. Ninety minutes after behavioral test completion, rats were killed by an overdose of pentobarbital (200 mg/kg, i.p.)…”

Section: Introductionmentioning

confidence: 99%

The Ventral Midline Thalamus (Reuniens and Rhomboid Nuclei) Contributes to the Persistence of Spatial Memory in Rats

Loureiro¹,

Cholvin²,

Lopez³

et al. 2012

Journal of Neuroscience

129

134

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The formation of enduring declarative-like memories engages a dialog between the hippocampus and the prefrontal cortex (PFC). Electrophysiological and neuroanatomical evidence for reciprocal connections with both of these structures makes the reuniens and rhomboid nuclei (ReRh) of the thalamus a major functional link between the PFC and hippocampus. Using immediate early gene imaging (c-Fos), fiber-sparing excitotoxic lesion, and reversible inactivation in rats, we provide evidence demonstrating a contribution of the ReRh to the persistence of a spatial memory. Intact rats trained in a Morris water maze showed increased c-Fos expression (vs home cage and visible platform groups: Ͼ500%) in the ReRh when tested in a probe trial at a 25 d delay, against no change at a 5 d delay; behavioral performance was comparable at both delays. In rats subjected to excitotoxic fiber-sparing NMDA lesions circumscribed to the ReRh, we found normal acquisition of the water-maze task (vs sham-operated controls) and normal probe trial performance at the 5 d delay, but there was no evidence for memory retrieval at the 25 d delay. In rats having learned the water-maze task, lidocaine-induced inactivation of the ReRh right before the probe trial did not alter memory retrieval tested at the 5 d or 25 d delay. Together, these data suggest an implication of the ReRh in the long-term consolidation of a spatial memory at the system level. These nuclei could then be a key structure contributing to the transformation of a new hippocampal-dependent spatial memory into a remote one also depending on cortical networks.

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“…RE is reciprocally connected with the hippocampus (HF) and the medial prefrontal cortex (mPFC) (Herkenham 1978;Wouterlood et al 1990; Dollerman-Van der Weel and Witter 1996; Risold et al 1997;Bokor et al 2002;McKenna and Vertes 2004;Vertes 2002Vertes , 2004Vertes , 2006Cavdar et al 2008), and as such appears to be critically involved in the two way communication between these structures. RE is a major route through which the mPFC influences the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

Collateral projections from nucleus reuniens of thalamus to hippocampus and medial prefrontal cortex in the rat: a single and double retrograde fluorescent labeling study

2011

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The nucleus reuniens (RE) of the midline thalamus has been shown to strongly innervate structures of the limbic forebrain, prominently including the hippocampus (HF) and the medial prefrontal cortex (mPFC) and to exert pronounced excitatory effects on HF and mPFC. It was unknown, however, whether RE projections to, and hence actions on, the HF and mPFC originate from a common or largely separate groups of RE neurons. Using fluorescent retrograde tracing techniques, we examined the patterns of distribution of RE cells projecting to HF, to the mPFC or to both sites via axon collaterals. Specifically, injections of the retrograde tracers Fluorogold (FG) or Fluororuby (FR) were made in the mPFC and in various subfields of HF and patterns of single (FG or FR) or double labeled (FG + FR) cells in RE were determined. Pronounced numbers of (single) labeled neurons were present throughout RE with FG or FR injections, and although intermingled in RE, cells projecting to the mPFC were preferentially distributed along the midline or in the perireuniens nucleus (pRE), whereas those projecting to HF occupied a wide mediolateral cross sectional area of RE lying between cells projecting to the mPFC. Approximately, tenfold more labeled cells were present in RE with ventral compared to dorsal CA1 injections. Like single labeled neurons, double labeled cells were found throughout RE, but were most densely concentrated in areas of greatest overlap of FG+ and FR+ neurons or mainly in the lateral one-third of RE, medial to pRE. Depending on specific combinations of injections, double labeled cells ranged from approximately 3-9% of the labeled neurons. The nucleus reuniens has been shown to be a vital link in limbic subcortical-cortical communication and recent evidence indicates a direct RE involvement in hippocampal and medial prefrontal cortical-dependent behaviors. The present findings indicate that RE is critically positioned to influence the HF and mPFC, and their associated behaviors, via separate or collateral projections to these sites.

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The pathways connecting the hippocampal formation, the thalamic reuniens nucleus and the thalamic reticular nucleus in the rat

Cited by 72 publications

References 47 publications

Dendritic morphology changes in neurons from the prefrontal cortex, hippocampus and nucleus accumbens in rats after lesion of the thalamic reticular nucleus

Dendritic morphology changes in neurons from the prefrontal cortex, hippocampus and nucleus accumbens in rats after lesion of the thalamic reticular nucleus

The Ventral Midline Thalamus (Reuniens and Rhomboid Nuclei) Contributes to the Persistence of Spatial Memory in Rats

Collateral projections from nucleus reuniens of thalamus to hippocampus and medial prefrontal cortex in the rat: a single and double retrograde fluorescent labeling study

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