The Pharmacological Properties in Animals of Ct1341???a New Steroid Anaesthetic Agent

Child, Korean J; Currie, J.P.; Davis, Brian; Dodds, Michael; Pearce, D. R.; Twissell, D.J.

doi:10.1097/00132586-197204000-00049

Cited by 44 publications

(56 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Polyvinyl cannulae had been implanted chronically in their right external jugular vein and descending aorta at least 4 days before the first experiment (Child et al, 1971).…”

Section: Methodsmentioning

confidence: 99%

Anaesthetic, cardiovascular and respiratory effects of a new steroidal agent CT 1341: a comparison with other intravenous anaesthetic drugs in the unrestrained cat

Child¹,

Davis²,

Dodds³

et al. 1972

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

Summary1. The anaesthetic, cardiovascular, respiratory and adverse effects produced by the intravenous injection of CT 1341, thiopentone, methohexitone, pentobarbitone, propanidid and ketamine have been compared in unrestrained cats prepared with chronically implanted venous and arterial cannulae. Aortic blood pressure and heart rates were monitored before, during and after loss of consciousness. 2. CT 1341 produced rapid induction of anaesthesia followed by moderately rapid recovery, was active over a wide range of doses and caused minimal respiratory depression and few adverse effects. It caused an initial shortlasting tachycardia and fall in aortic blood pressure succeeded by a secondary depressor response. 3. The safety margin was narrower with the barbiturate drugs than with CT 1341, and large doses induced apnoea and respiratory depression. Small doses of methohexitone elicited excitatory effects and large doses caused severe respiratory and circulatory depression, and recovery from anaesthesia was protracted. 4. Propanidid induced short-lasting light anaesthesia. The safety margin was narrowest with this drug and induction was associated with adverse circulatory, respiratory and other effects. 5. Ketamine was active over a wide range of doses but exhibited qualitatively different properties from the other anaesthetics. Induction was slower after small doses and these produced circulatory stimulation, catatonia and bizarre behavioural effects. Large doses caused respiratory and circulatory depression and recovery was protracted. 6. It is concluded that CT 1341 has a wider therapeutic latitude, produces less respiratory depression and has other advantages over the currently used intravenous anaesthetics.

show abstract

“…Polyvinyl cannulae had been implanted chronically in their right external jugular vein and descending aorta at least 4 days before the first experiment (Child et al, 1971).…”

Section: Methodsmentioning

confidence: 99%

Anaesthetic, cardiovascular and respiratory effects of a new steroidal agent CT 1341: a comparison with other intravenous anaesthetic drugs in the unrestrained cat

Child¹,

Davis²,

Dodds³

et al. 1972

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…These veins were preferred since they are visible and in the relaxed animal accurate venepuncture was found to be relatively easy. Child et al (1971) showed that different animals vary in their susceptibility to CTl341. Only Macaca irus monkeys were used in this work, and it is possible that slightly differing results could be obtained in other monkey species.…”

Section: Resultsmentioning

confidence: 99%

“…Its composition, pharmacology and toxicology in animal species including the monkey have been described by Child et al (1971) who showed that when administered by the intravenous route CTI341 has a wide therapeutic index. The work now presented describes the results obtained in using CT] 34] as an alternative to phencyclidine in monkeys.…”

Section: L'emploi De L'anesthesique Ct 1341 ('Saffan') Sur Les Singesmentioning

confidence: 99%

See 1 more Smart Citation

Use of CT1341 anaesthetic ('Saffan') in monkeys

Box¹,

Ellis²

1973

Lab Anim

View full text Add to dashboard Cite

SUMMARYAn intramuscular dose of 12 mg/kg of this steroid anaesthetic produced sedation in cynomolgus monkeys, and higher doses (up to 60 mg/kg) produced light anaesthesia lasting up to 3 hours. Surgical anaesthesia could be induced by a single injection of 120 mg/kg, or by an intramuscular injection of 18 mg/kg followed by 6-12 mg/kg intravenously.No clinical or pathological effects were observed after daily use of the anaesthetic for 4 weeks.

show abstract

“…The effects of cremophor EL were studied in 13 in PCWP, per cent at the end of infusion, -32 per cent 150 minutes after the end of infusion). Heart rate and systemic vascular resistance did not vary significantly.…”

Section: The Effects Of Cremophor El In the Anaesthetized Dogmentioning

confidence: 99%

The effects of cremophor EL in the anaesthetized dog

et al. 1987

View full text Add to dashboard Cite

The effects of cremophor EL in the anaesthetized dogThe effects of cremophor EL were studied in 13 in PCWP, per cent at the end of infusion, -32 per cent 150 minutes after the end of infusion). Heart rate and systemic vascular resistance did not vary significantly. Pulmonary vascular resistance increased at the end of infusion, five and ten minutes after the end of infusion (+ 734, +548 and +439 per cent respectively). Plasma volume decreased I0 and 30 minutes after the end of infusion (-28 and -30.5 per cent respectively). per cent at the end of iofusion). Platelet and white cell counts decreased markedly. There was a marked and sustained increase in plasma hista-

show abstract

The Pharmacological Properties in Animals of Ct1341???a New Steroid Anaesthetic Agent

Cited by 44 publications

References 0 publications

Anaesthetic, cardiovascular and respiratory effects of a new steroidal agent CT 1341: a comparison with other intravenous anaesthetic drugs in the unrestrained cat

Anaesthetic, cardiovascular and respiratory effects of a new steroidal agent CT 1341: a comparison with other intravenous anaesthetic drugs in the unrestrained cat

Use of CT1341 anaesthetic ('Saffan') in monkeys

The effects of cremophor EL in the anaesthetized dog

Contact Info

Product

Resources

About