The Pharmacological Properties of “Laudolissin”—a Long‐acting Curarizing Agent*

Collier, H. O. J.; Macauley, Barbara

doi:10.1111/j.1476-5381.1952.tb00707.x

Cited by 18 publications

(9 citation statements)

References 18 publications

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“…Histamine release by pancuronium was investigated in two species. In cats, the delayed depressor response described by Collier & Macauley (1952) was studied and in guinea-pigs the broncoconstriction test of Konzett & Rossler (1940) was used.…”

Section: Histamine Releasementioning

confidence: 99%

The Pharmacology of Pancuronium Bromide (ORG.NA97), a New Potent Steroidal Neuromuscular Blocking Agent

Buckett¹,

Marjoribanks²,

Marwick³

et al. 1968

British Journal of Pharmacology and Chemotherapy

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The incorporation of a biologically active group into a naturally occurring structure is an interesting approach to new pharmacological agents. For example, when an acetylcholine-like structure is incorporated in ring-A of 5a-androstane-17-one or 5a-pregnan-20-one, neuromuscular blocking agents of up to one-fifteenth the potency of tubocurarine are obtained (Lewis, Martin-Smith, Muir & Ross, 1967). Although of limited clinical value, such compounds present useful leads for further chemical exploration, particularly the synthesis of bisquaternary amino-steroidal salts. A series of 2,8,16,3-diamino-5a-androstane-3a,17p-diol dimethohalide derivatives was described by Buckett, Hewett & Savage (1967). One of them, 2ft,16,/-dipiperidino-5a-androstane3a,17,8-diol diacetate dimethobromide (code number Org.NA97; approved name pancuronium bromide), is a potent neuromuscular blocking agent and in the experiments described in this paper its actions were compared with those of tubocurarine chloride. Cats were anaesthetized with a mixture of chloralose (70 mg/kg) and sodium pentobarbitone (12 mg/kg) injected intraperitoneally; rabbits and dogs were anaesthetized with sodium pentobarbitone (45 mg/kg) injected intravenously, and hens with sodium barbitone (200 mg/kg) injected intravenously. In all species the trachea was intubated and artificial ventilation applied throughout each experiment Twitches and tetani of a gastrocnemius muscle were elicited by stimulating the peripheral portion of the crushed sciatic nerve in the popliteal space with rectangular shocks of

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Section: Histamine Releasementioning

confidence: 99%

The Pharmacology of Pancuronium Bromide (ORG.NA97), a New Potent Steroidal Neuromuscular Blocking Agent

Buckett¹,

Marjoribanks²,

Marwick³

et al. 1968

British Journal of Pharmacology and Chemotherapy

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“…They have been tested on different tissues and by different methods: in some investigations (MacIntosh and Paton, 1949; Collier and Macauley, 1952) an effect of the released histamine, such as skin wealing, or delayed blood-pressure response, has been used to indicate histamine release, in others the released histamine has been directly measured by pharmacological or chemical methods (Alam, Anrep, Barsoum, Talaat, and Wieninger, 1939; Rocha e Silva and Schild, 1949;Feldberg and Paton, 1951;McIntire, Roth, and Sproull, 1951). For the purpose of a quantitative comparison of histamine-releasing activity it is desirable that not only the amount of histamine released but also the concentration of the releaser at the site of action should be known.…”

mentioning

confidence: 99%

Quantitative Measurement of the Histamine‐releasing Activity of a Series of Mono‐alkyl‐amines Using Minced Guinea‐pig Lung

Mongar

Schild

1953

British Journal of Pharmacology and Chemotherapy

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“…Muscle relaxants such as tubocurarine (Comroe and Dripps, 1946;Grob, Lilienthal and Harvey, 1947;Collier and Macauley, 1952;Smith, 1957;Westgate, Schultz and Van Bergen, 1961;Salem, King and El Etr, 1968;McDowell and Clarke, 1969); gallamine (Sniper, 1952;Smith, 1957); suxamethonium (Bourne, Collier and Gomers, 1952;Smith, 1957;Jerums, Whittingham and Wilson, 1967).…”

Section: Discussionmentioning

confidence: 99%

Histamine Release in Man by Propanidid and Thiopentone: Pharmacological Effects and Clinical Consequences

Lorenz

Doenicke

Meyer

et al. 1972

British Journal of Anaesthesia

124

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The Pharmacological Properties of “Laudolissin”—a Long‐acting Curarizing Agent*

Cited by 18 publications

References 18 publications

The Pharmacology of Pancuronium Bromide (ORG.NA97), a New Potent Steroidal Neuromuscular Blocking Agent

The Pharmacology of Pancuronium Bromide (ORG.NA97), a New Potent Steroidal Neuromuscular Blocking Agent

Quantitative Measurement of the Histamine‐releasing Activity of a Series of Mono‐alkyl‐amines Using Minced Guinea‐pig Lung

Histamine Release in Man by Propanidid and Thiopentone: Pharmacological Effects and Clinical Consequences

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