The physiology of wound healing

Singh, Shailendra; Young, Alistair; McNaught, Clare-Ellen

doi:10.1016/j.mpsur.2017.06.004

Cited by 243 publications

(262 citation statements)

References 17 publications

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“…The use of autologous nasal mucosa grafts on rabbit has shown to improve re-epithelization. Utilizing light and scanning electron microscopy, Topdag et al had demonstrated that the ciliary epithelium covered greater area, had more mature and sophisticated cilia, and had less hypertrophied epithelium in grafted tissue compared to the non-grafted tissue [6].…”

Section: Cell and Tissue Therapymentioning

confidence: 99%

Current and Alternative Therapies for Nasal Mucosa Injury: A Review

Selvarajah

Saim

Idrus

et al. 2020

IJMS

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Nasal mucosa injury can be caused by trauma, radiotherapy, chronic infection such as sinusitis, and post sinus surgery. The rate of healing and its treatment are important in the recovery of patients especially in post sinus surgery, which introduces new injuries. In this review, the current knowledge in terms of the mechanism underlying nasal wound healing was initially discussed. The currently available treatment options for enhancement of wound healing following sinus surgery were discussed and these had included intravenous antibiotics or steroids, various nasal sprays, and nasal packing. In addition, emerging alternative therapies in nasal mucosa wound healing such as herbal medicine and the advancement of regenerative medicine therapies such as stem cells and their byproducts were also discussed. Despite the various available treatment options for wound healing in nasal mucosa, rigorous strong evidence of their efficacy is gravely warranted in order to recommend them as part of the treatment modality.

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Section: Cell and Tissue Therapymentioning

confidence: 99%

Current and Alternative Therapies for Nasal Mucosa Injury: A Review

Selvarajah

Saim

Idrus

et al. 2020

IJMS

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“…Both acute and chronic wounds are major health concerns with considerable costs for health services and can lead to morbidity in poor treatment conditions. Wound healing involves a gradual progress to full skin restoration consisting of complicated sequential steps, where numerous biochemical processes take place in cellular level …”

Section: Introductionmentioning

confidence: 99%

“…However, these products also limit the passage of liquids which is not preferred for the case of exudative wounds. There is a lack of an inexpensive product possessing all desired features of a modern dressing, which can also manage controlled drug/protein/cell delivery to the wounded area under chronic exudate conditions …”

Section: Introductionmentioning

confidence: 99%

“…Low‐cost polysaccharide hydrogels have been successfully used as topical drug delivery matrices for wound dressing because they contain functional molecules that aid in the attachment, proliferation and differentiation of cells . Some of the most promising and widely studied polysaccharides are starch, alginate, chitosan and pectin, owing to their similarities to extra cellular matrix, good biological performances, and low costs .…”

Section: Introductionmentioning

confidence: 99%

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Low‐methoxyl pectin–zeolite hydrogels controlling drug release promote in vitro wound healing

Kocaaga

Kürkçüoğlu

Tatlıer

et al. 2019

J of Applied Polymer Sci

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This study presents the design of novel hydrogel films, based on low-methoxyl (LM) pectin and NaA-or ZnA-zeolite particles, to serve as wound dressing materials with controlled drug delivery properties. We studied the effects of the preparation method of hydrogels, the amounts of crosslinker, drug and zeolite, and the type of cation in zeolites on the drug release mechanisms from the hydrogels. Ionic strengths of both film and external medium dictated the drug release behavior of the films, while the other parameters also played essential roles. NaAzeolite hydrogels prepared using membrane diffusion controlled system, could reach a drug release ratio of 86% within 5 h. The drug-free hydrogels displayed no cytotoxicity while supporting cell proliferation and migration. Our cost-effective LM pectin-zeolite hydrogels promise to be effective wound dressing materials with controlled drug delivery ability, transparency, good swelling properties, ability to hold fluids, good oxygen transmission rate, and biocompatibility.Pectin is a water soluble polysaccharide mostly extracted from citrus peels. It is a byproduct or waste product of fruit juice industry; therefore, it is easily available and cheap. It is mainly composed of linear chains of galacturonic acid residues. Pectin is referred to as low-methoxyl pectin (LM-pectin) in case the degree of esterification of the carboxylic acid groups is <50%. LM pectin forms three-dimensional (3D) network gels of Ca 2+ ion-bridged dimers to induce an "egg box shell" structure, 4 which makes it an Additional Supporting Information may be found in the online version of this article.

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“…Dôvodov nehojenia je mnoho, ale za primárne možno považovať najmä bakteriálnu kolonizáciu, bielkovinový status pacienta a jeho celkový stav. K ďalším príčinám ovplyvňujúcim proces hojenia patria patologický tlak, metabolické poruchy, malígne ochorenie, porucha krvotvorby, podvýživa, hypoxia, imunosupresie, chronické choroby (Singh, Young, McNaught, 2017). Podľa uvedenia Stryja et al (2011) sa tieto faktory delia na systémové a lokálne, resp.…”

unclassified

Efekt Microdacynu v procese hojenia chronických rán

Pavelová¹,

Krištofová²,

Mesárošová³

et al. 2019

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Proces hojenia nie je ovplyvnený iba samotným ošetrovaním rany, ale sú prítomné ďalšie faktory, ktoré ovplyvňujú hojenie rán. Cieľ: Zhodnotenie procesu hojenia chronických rán pomocou hydrogélu Microdacyn a vplyvu ďalších faktorov. Metódy: Výskumnú vzorku tvorilo celkovo 124 pacientov z agentúr domácej ošetrovateľskej starostlivosti (57 %) a z kliniky chirurgie a cievnej chirurgie (43 %) FN v Nitre. Metódou zberu dát bola metóda pozorovania resp. posúdenie rany a procesu hojenia rany použitím pozorovacieho hárka Bates-Jensen podľa odporúčania autoriek Pokorná, Mrázová (2012). Pre hodnotenie rozdielov stavu rany v troch časových bodoch bol použitý Studentov t-test pre závislé výbery. Pre skúmanie faktorov ovplyvňujúcich efektivitu liečby bola použitá metóda viacnásobnej lineárnej regresie. Výsledky: Kvantitatívne hodnotenie procesu hojenie rán prebiehalo v 3 hlavných etapách. Medzi jednotlivými etapami hojenia rán boli zistené štatisticky významné rozdiely a najväčší posun v celkovom skóre bol zaznamenaný medzi prvou a druhou etapou merania. Vo všetkých etapách boli zaznamenané štatisticky významné rozdiely vo všetkých 13 kategóriách (vlastnostiach) rany. Zhojenie rany pomocou Microdacynu sa dosiahlo v priemere za 28 dní (Min=8; Max=58). Najhoršie hojenie rán bolo vyhodnotené pri vredoch predkolenia. V prvej etape hojenia rán vstupoval do procesu hojenia rán negatívne faktor CRP. V druhej a tretej etape na stav rany vplývali zo systémových faktorov najmä bielkoviny, albumín a tiež CRP, horšie výsledky boli zaznamenané viac u žien. Zároveň negatívne ovplyvňoval stav rany aj diabetes mellitus. Na celkové zlepšenie stavu chronickej rany vplývala najmä hodnota bielkovín a albumínu, BMI a CRP. Implikácie: Na základe kvantitatívnych analýz môžeme konštatovať, že hojenie rany je najviac ovplyvnené samotným lokálnym ošetrením. V jednotlivých etapách vstupujú do procesu hojenia rany aj ďalšie faktory, najmä stav bielkovín.

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The physiology of wound healing

Cited by 243 publications

References 17 publications

Current and Alternative Therapies for Nasal Mucosa Injury: A Review

Current and Alternative Therapies for Nasal Mucosa Injury: A Review

Low‐methoxyl pectin–zeolite hydrogels controlling drug release promote in vitro wound healing

Efekt Microdacynu v procese hojenia chronických rán

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