The Pineal Gland and Mammalian Photoperiodism

Goldman, Bruce D.; Darrow, Janet M.

doi:10.1159/000123579

Cited by 258 publications

(98 citation statements)

References 62 publications

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“…In addition, afternoon melatonin injections in the Djungarian hamster also attenuate the castration-induced increase in serum FSH and LH. This finding supports the conclusion that melatonin mediates the effects of short daylength on the reproductive system (Goldman & Darrow, 1983). …”

Section: Methodssupporting

confidence: 89%

Influence of short days on diurnal patterns of serum gonadotrophins and prolactin concentrations in the male Djungarian hamster, Phodopus sungorus

Yellon¹,

Goldman²

1987

Reproduction

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Section: Methodssupporting

confidence: 89%

Influence of short days on diurnal patterns of serum gonadotrophins and prolactin concentrations in the male Djungarian hamster, Phodopus sungorus

Yellon¹,

Goldman²

1987

Reproduction

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“…1) (Glass, 1986;Korytko et al, 1995 (Hoffmann, 1979;Goldman and Darrow, 1983;Reiter, 1987). Recent evidence indicates that melatonin secretion (Ruf et al, 1997) and hypothalamic GnRH content …”

Section: Resultsmentioning

confidence: 99%

Phenotypic differences in the GnRH neuronal system of deer mice Peromyscus maniculatus under a natural short photoperiod

Korytko

Vessey²,

Blank³

1998

Reproduction

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“…In immature Djungarian hamsters short photoperiods hamper gonadal growth in prepubertal male (4,5) and female (6) animals for months. There is strong evidence that in Djungarian hamsters, as in other rodents (7), the daily temporal pattern of synthesis and release of melatonin by the epiphysis may be involved in transforming photoperiodic information (8,9), i.e. from 10 days of age onwards when the neural photoperiodic transduction system is well established (10).…”

Section: Introductionmentioning

confidence: 99%

Enhanced serum oestrogen levels and highly steroidogenic, luteinized atretic follicles in the ovaries of the Djungarian hamster (Phodopus sungorus) kept under a short photoperiod from birth

Hurk

Dijkstra²,

Jong³

2002

European Journal of Endocrinology

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Enhanced serum oestrogen levels and highly steroidogenic, luteinized atretic follicles in the ovaries of the Djungarian hamster (Phodopus sungorus ) kept under a short photoperiod from birth R van den Hurk, G Dijkstra and F H de Jong AbstractObjective: In contrast to the elaborate information available on the effects of the photoperiod on the testes of hamsters, little is known about the influence on their ovaries. This study aimed to describe the ovarian follicular development and steroid hormone production in Djungarian hamsters kept from birth under a short daylight regime. Design and Methods: Female Djungarian hamsters (Phodopus sungorus ) were kept under two different light regimes: (i) 16 h light:8 h darkness (long daylight; LD) and (ii) 4 h light:20 h darkness (short daylight; SD). They were killed at 28, 56 and 80 days after birth; blood and ovaries were collected. Ovaries were either fixed in Bouin's solution or frozen. Fixed material was dehydrated, embedded in paraffin, serially sectioned at 5 mm and stained with haematoxylin and eosin, whereafter all healthy and atretic follicles were classified and counted. 3b-Hydroxysteroid dehydrogenase (3b-HSD) was histochemically demonstrated in 10 mm sections of frozen ovaries. Serum oestradiol-17b and progesterone levels were determined by RIA. Results: The numbers of healthy preantral and antral follicles were higher in LD than in SD hamsters. Antral follicles did not significantly differ in number during development in LD hamsters, but they were completely absent from 80-day-old SD animals. In LD animals the number of apoptotic preantral follicles dramatically increased with age. In SD animals the numbers of apoptotic antral follicles strongly decreased with age, whereas numerous non-apoptotic follicles with luteinized granulosa cells and a degenerated oocyte appeared, and in increasing numbers with age. During development, moderate 3b-HSD activity was present in interstitial cells, theca cells of healthy follicles, and in both theca and granulosa cells of degenerating follicles. Strong enzyme activity was found in the hypertrophied granulosa cells of luteinized atretic follicles. Mean serum progesterone values varied from 2 to 6 nmol/l and were not different in LD and SD hamsters. Mean serum oestradiol levels varied from 132 to 542 and 325 to 2353 pmol/l in LD and SD hamsters respectively. The highest oestradiol levels were found in SD animals at day 28 of development. Conclusions: Folliculogenesis was dramatically disturbed in Djungarian hamsters raised under a short photoperiod. These animals developed high serum oestradiol levels and numerous luteinized atretic follicles with highly steroidogenic granulosa cells, which appear to be the source of the increased serum oestradiol levels.

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The Pineal Gland and Mammalian Photoperiodism

Cited by 258 publications

References 62 publications

Influence of short days on diurnal patterns of serum gonadotrophins and prolactin concentrations in the male Djungarian hamster, Phodopus sungorus

Influence of short days on diurnal patterns of serum gonadotrophins and prolactin concentrations in the male Djungarian hamster, Phodopus sungorus

Phenotypic differences in the GnRH neuronal system of deer mice Peromyscus maniculatus under a natural short photoperiod

Enhanced serum oestrogen levels and highly steroidogenic, luteinized atretic follicles in the ovaries of the Djungarian hamster (Phodopus sungorus) kept under a short photoperiod from birth

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