The polymorphism of the β3-adrenergic receptor gene is associated with reduced low-density lipoprotein particle size

Genetic Influences of .BETA.-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients

“…In addition, the previously reported frequencies of two β 2 ADR SNPs, Gly16Arg and Glu27Gln, in a Japanese ( 28 ) and a Taiwanese ( 29 ) cohort were identical to the respective frequencies determined here. Finally, the frequency of Trp64Arg for the β 3 ADR reflected the findings of another Japanese group ( 30 ). Based on the accordance of our findings with these previous studies, our results would seem to be an accurate evaluation of the frequencies of these five β ADR SNPs.…”

The Trp64Arg polymorphism of the β3-adrenergic receptor gene is associated with increased small dense low-density lipoprotein in a rural Japanese population: the Mima study

“…This result is consistent with a previous study [27], although the method used in the determination of LDL particle size (at the peak size by electrophoresis using nondenaturing 2% to 16% polyacrylamide gradient gels in plasma samples [28], as originally described by Krauss and Burke [15]) was different. For the LipoPrint System, this is the first description that the area of sdLDL was larger in Arg carriers than in non-Arg carriers, as shown in Table 1.…”

LDL particle size, fat distribution and insulin resistance in obese children

“…In men with abdominal obesity with blunted growth hormone secretion, growth hormone treatment marginally increased the mean LDL diameter (Svensson et al, 2000). Furthermore, serum adiponectin (Kazumi et al, 2004) and polymorphism of the beta3-adrenergic receptor gene (Okumura et al, 2003), which have been shown to be related to obesity and insulin sensitivity, were also associated with LDL particle size in healthy Japanese subjects.…”