The Possible Effect of Dietary Fiber Intake on the Metabolic Patterns of Dyslipidemia Subjects: Cross-Sectional Research Using Nontargeted Metabolomics

Han, Youngmin; Jang, Kyunghye; Kim, Unchong; Huang, Xiucai; Kim, Min‐Joo

doi:10.1016/j.tjnut.2023.07.014

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…In contrast, plasma metabolites (S)-3-hydroxybutyrylcarnitine were found to exert an inhibitory effect. This compound is commonly involved in lipid metabolism and energy production ( Han et al, 2023 ), but its specific mechanism of action in increasing the risk of OP is unknown.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota, plasma metabolites, and osteoporosis: unraveling links via Mendelian randomization

Lu,

Cai,

Shi

et al. 2024

Front. Microbiol.

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ObjectiveOsteoporosis, characterized by reduced bone density and heightened fracture risk, is influenced by genetic and environmental factors. This study investigates the interplay between gut microbiota, plasma metabolomics, and osteoporosis, identifying potential causal relationships mediated by plasma metabolites.MethodsUtilizing aggregated genome-wide association studies (GWAS) data, a comprehensive two-sample Mendelian Randomization (MR) analysis was performed involving 196 gut microbiota taxa, 1,400 plasma metabolites, and osteoporosis indicators. Causal relationships between gut microbiota, plasma metabolites, and osteoporosis were explored.ResultsThe MR analyses revealed ten gut microbiota taxa associated with osteoporosis, with five taxa positively linked to increased risk and five negatively associated. Additionally, 96 plasma metabolites exhibited potential causal relationships with osteoporosis, with 49 showing positive associations and 47 displaying negative associations. Mediation analyses identified six causal pathways connecting gut microbiota to osteoporosis through ten mediating relationships involving seven distinct plasma metabolites, two of which demonstrated suppression effects.ConclusionThis study provides suggestive evidence of genetic correlations and causal links between gut microbiota, plasma metabolites, and osteoporosis. The findings underscore the complex, multifactorial nature of osteoporosis and suggest the potential of gut microbiota and plasma metabolite profiles as biomarkers or therapeutic targets in the management of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota, plasma metabolites, and osteoporosis: unraveling links via Mendelian randomization

Lu,

Cai,

Shi

et al. 2024

Front. Microbiol.

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Oxidative balance score and associations with dyslipidemia and mortality among US adults: A mortality follow‐up study of a cross‐sectional cohort

Kong,

Gao,

Wang

2024

J Parenter Enteral Nutr

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BackgroundOxidative stress has been implicated in the pathogenesis and progression of dyslipidemia. We aimed to investigate the association between the oxidative balance score, and dyslipidemia, as well as to assess the mortality risk associated with oxidative balance score in patients with dyslipidemia.MethodsWe performed a mortality follow‐up study of a cross‐sectional cohort of 26,118 adults from the National Health and Nutrition Examination Survey 1999–2018. The total oxidative balance score was calculated by 16 dietary nutrients (dietary oxidative balance score) and four lifestyle factors (lifestyle oxidative balance score). Weighted Cox proportional hazard model was applied to determine the relationship between oxidative balance score and all‐cause or cardiovascular disease (CVD) mortality within the dyslipidemia group.ResultsDuring a median follow‐up of 118 months, 2448 all‐cause deaths (766 CVD‐related) occurred. A significant negative correlation was observed between total oxidative balance score, dietary oxidative balance score, lifestyle oxidative balance score, and dyslipidemia. The multivariable‐adjusted odds ratios and 95% CIs for dyslipidemia were 0.86 (0.77–0.97), 0.80 (0.72–0.91), and 0.63 (0.56–0.70), respectively, when comparing the second, third, and fourth quartiles of total oxidative balance score to the reference lowest quartile (P for trend <0.0001). Increasing total oxidative balance score was inversely associated with all‐cause (hazard ratio [HR] = 0.98, 95% CI 0.98–0.99) and CVD‐specific mortality (HR = 0.98, 95% CI 0.97–0.99) in participants with dyslipidemia.ConclusionsOxidative balance score is inversely associated with dyslipidemia and linked to all‐cause and CVD‐related mortality, highlighting the potentially protective role of an antioxidant‐rich diet against dyslipidemia.

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Role of dietary fibres in cardiometabolic diseases

Dahm,

Langmann,

Nannsen

et al. 2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review This review highlights recent developments in understanding the role of dietary fibre and specific fibre types on risk and management of cardiometabolic disease with a focus on the causal pathways leading to cardiometabolic diseases, namely weight management, glycaemic control, and lipid levels, as well as the latest findings for cardiovascular disease outcomes such as coronary heart disease, stroke, and mortality. Evidence for mechanisms through gut microbiota are also briefly reviewed. Recent findings Dietary fibre intake is associated with improved weight management, the extent of which may depend on the subtype of dietary fibre. Overall dietary fibre intake reduces blood glucose and HbA1c, however soluble fibres may be particularly effective in reducing HbA1c, fasting blood glucose and blood lipids. Individual meta-analyses and umbrella reviews of observational studies on dietary fibre, as well as major fibre types, observed inverse associations with incident coronary heart disease, stroke, and mortality due to cardiovascular disease. As different types of fibres exerted different health benefits, fibre diversity (i.e. combinations of fibres) should be further investigated. Summary Dietary fibres improve both short-term and long-term cardiometabolic disease risk factors and outcomes, and thus should be on every menu.

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The Possible Effect of Dietary Fiber Intake on the Metabolic Patterns of Dyslipidemia Subjects: Cross-Sectional Research Using Nontargeted Metabolomics

Cited by 3 publications

References 33 publications

Gut microbiota, plasma metabolites, and osteoporosis: unraveling links via Mendelian randomization

Gut microbiota, plasma metabolites, and osteoporosis: unraveling links via Mendelian randomization

Oxidative balance score and associations with dyslipidemia and mortality among US adults: A mortality follow‐up study of a cross‐sectional cohort

Role of dietary fibres in cardiometabolic diseases

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