The Possible Prognostic Significance of Immunophenotype in Feline Alimentary Lymphoma: a Pilot Study

Patterson-Kane, Janet C.; Kugler, B.Perrins; Francis, Kathryn

doi:10.1016/j.jcpa.2003.09.008

Cited by 43 publications

(47 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In alimentary lymphoma, while the ratio of T-and B-cell phenotypes varied in previous studies [16,25,27], a high incidence of T-cell subtype was observed in the present study. In mediastinal lymphoma, the B-cell subtype was found up to 1/3 of mediastinal cases in the present study, although there was a report about significant correlation with the T-cell phenotype [9].…”

Section: Discussionsupporting

confidence: 43%

Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

Chino

Fujino

Kobayashi

et al. 2013

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Of the various classification systems for non-Hodgkin's lymphoma, the updated Kiel classification is valuable for veterinary practice, because of its utility to classify the subtypes not only by histopathology but also by cytomorphology. However, there are only a few reports of small number of feline lymphomas to apply the updated Kiel classification. In this study, immunogical subtypes and morphology of 76 feline lymphomas were evaluated and classified into subtypes of the updated Kiel classification. Of the cases, 49% were T-cell lymphoma, 25% were B-cell lymphoma and 26% were undetermined immunological subtype. Based on the updated Kiel classification, most subtypes were identified also in feline lymphomas as in dogs and humans. Globule leukocyte lymphoma was specific for cats and relatively common in feline alimentary lymphomas. Of the present cases, 64% were high-grade subtypes, whereas 36% were low-grade subtypes. The present study indicated that feline lymphomas could be morphologically classified by the modified updated Kiel classification.

show abstract

Section: Discussionsupporting

confidence: 43%

Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

Chino

Fujino

Kobayashi

et al. 2013

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

“…These observations suggest that these parameters could be important diagnostic features of ITCL, although these criteria are not considered in the current WHO classification scheme. 6 A similar variability in cellular morphology has also been observed in a smaller number of lymphomas involving the feline alimentary tract 4 : 6 ITCLs out of 23 alimentary lymphomas consisted of 4 small-cell lymphomas and 2 large-cell lymphomas, whereas every B-cell lymphoma was of the large-cell type.…”

supporting

confidence: 55%

Feline Intestinal T-Cell Lymphoma: Assessment of Morphologic and Kinetic Features in 30 Cases

2009

View full text Add to dashboard Cite

Abstract. In this study, 30 feline intestinal T-cell lymphomas (ITCLs) from 77 cats with gastrointestinal lymphoma were evaluated. Neoplastic lesions were composed predominantly of small (n 5 21) or medium to large (n 5 9) anaplastic cells. Different patterns of tumor growth were observed. A starry-sky pattern was evident in 7 cases (23.3%), fibrosis in 18 cases (60%), and neovascularization in 19 cases (63.3%). The cell proliferation index (assessed by MIB1 [mindbomb homolog 1] immunohistochemistry) ranged from 0.21% to 66.91%. Mean MIB1 index was 3.49% within the first 33rd percentile, 18.31% within the second 33rd percentile, and 40.16% within the third 33rd percentile (P , 0.000001). Microscopic and kinetic features provided evidence that ITCL in cats exhibits a spectrum in cytological composition and growth patterns that could putatively reflect differences in biologic behavior.

show abstract

“…In cats, there have been present insufficient data on outcome between B and T lymphomas. In a study on feline alimentary lymphomas, there was no significant difference in survival time between cats with Bcell lymphoma and those with T-cell lymphoma [9]. However, the number of cases was so small in the study that further investigation should be required to evaluate the prognostic significance of immunophenotype in cats.…”

mentioning

confidence: 82%

Comparison between Immunohistochemistry and Genetic Clonality Analysis for Cellular Lineage Determination in Feline Lymphomas

Sato

Fujino

Uchida

et al. 2011

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Clinical application of genetic clonality analysis by PCR has been available in feline lymphoma. However, it is in under dispute whether the analysis can be applied for cellular lineage determination. To evaluate utility of the analysis for lineage determination, the results between immunohistochemistry and the genetic analysis were compared. Based on the result with immunohistochemistry, sensitivity of the primer for IgH was 89% and specificity was 75%. Sensitivity of the primer for TCR was 25% and specificity was 100%. Cross-lineage IgH rearrangement was found in 25% of T-cell lymphomas. The present study suggests that the genetic analysis had better be applied as not a definite but an adjunctive tool for lineage determination in feline lymphomas.

show abstract

The Possible Prognostic Significance of Immunophenotype in Feline Alimentary Lymphoma: a Pilot Study

Cited by 43 publications

References 6 publications

Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

Feline Intestinal T-Cell Lymphoma: Assessment of Morphologic and Kinetic Features in 30 Cases

Comparison between Immunohistochemistry and Genetic Clonality Analysis for Cellular Lineage Determination in Feline Lymphomas

Contact Info

Product

Resources

About