The possible protective and therapeutic effects of ginger and cinnamon on the testis and coda epididymis of streptozotocin-induced-diabetic rats: Histological and biochemical studies

Faddladdeen, Khadija Abdul jalil

doi:10.1016/j.sjbs.2022.103452

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…These results are consistent with previous studies which demonstrated a decrease in the average number of Leydig cells, diameter and epithelium thickness of seminiferous tubules, and Johnsen score in the testes of diabetes mellitus rats. [47][48][49][50][51][52][53] Diabetes mellitus causes hyperglycemia, which can increase reactive oxygen species (ROS) in all organs. Furthermore, oxidative stress caused by increased ROS can reduce luteinizing hormone (LH) secretion, which stimulates the growth of Leydig cells.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Methotrexate, Moringa oleifera Leaf Extract, and Andrographis paniculata Leaf Extract on the Testes of Hyperglycemic Wistar Rats

2023

TJNPR

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MTX has the potential to stimulate 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), activate AMP-activated protein kinase (AMPK), and regulate glucose uptake, and promote lipid oxidation in skeletal muscle. Pharmacological activation of AMPK in skeletal muscle plays a role in enhancing glucose uptake without insulin mediation. As a result, it is very beneficial for patients with T1DM. 6 Moringa oleifera (MO) and Andrographis paniculata (AP) leaf extracts have been reported to be very beneficial for diabetes mellitus patients in terms of controlling blood sugar levels. [7][8][9] Previous studies have reported that MO and AP leaf extracts reduce the negative effects of chronic hyperglycemia on various tissues. 10,11 In addition, it has been reported that the potential anti-inflammatory effects of MO and AP leaf extracts is due to the suppression activity of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathway. [12][13][14][15] This study investigates the potential antihyperglycemic and antiinflammatory effects of MTX, MO, and AP on the testes of male rodents with STZ-NA-induced hyperglycemia. We examined the individual and combined effects of these agents on the interleukin-6 (IL-6) levels in testicular tissue, number of Leydig cells, diameter and epithelial thickness of seminiferous tubules, and Johnsen score. [16][17][18] Materials and Methods Drugs and chemicalsThis study used the following materials: streptozotocin (STZ) made in the United States by BioWorld with a batch number 41910012-2, nicotinamide (NA) made in India by Jubilant Ingrevia with a batch number B-2208-NIA049, methotrexate made in Indonesia by PT Kalbe

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Section: Resultsmentioning

confidence: 99%

The Effects of Methotrexate, Moringa oleifera Leaf Extract, and Andrographis paniculata Leaf Extract on the Testes of Hyperglycemic Wistar Rats

2023

TJNPR

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“…Previous studies have reported that cinnamon has been the subject of many ethnopharmacological studies. These reports have pointed out that cinnamon is the source of bioactive compounds with protective properties against inflammation, oxidative stress, diabetes (regulation of insulin, glucose uptake), obesity, hypercholesterolemia, hypertension, and blood lipid profile (Cheng et al, 2022;Das et al, 2022;Faddladdeen, 2022;Li et al, 2022;Miah et al, 2022;Rasool et al, 2022;Senevirathne et al, 2022;Wu et al, 2022;Milagres de Almeida et al, 2023). Moreover, cinnamon has been used as anticancer agent (Hamidpour et al, 2015;Sadeghi et al, 2019;Rasool et al, 2022) and to treat of the dental problems (Gupta and Jain, 2015;Sethi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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2022

J. New Sci.

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This study was designed to examine the effect of the administration of essential oil (CEO) and aqueous extract (CE) of cinnamon on key enzymes related to diabetes, obesity and hypertension and kidneyliver and metabolic disorders indices in diabetic rats. Results of this study showed that the administration of CEO or CE to surviving diabetic rats inhibited α-amylase rate in small intestine by 48 and 42% for diabetic rats. Moreover, CEO or CE protect pancreas β-cells from death and damage and increase insulin sensibility by oral glucose tolerance test (OGTT), which leads to decrease of blood glucose level by 59.9 and 402% respectively as compared to untreated diabetic rats. In addition, this study demonstrated that administration of CEO or CE to diabetic rats ameliorated the glycogen rate in liver and muscle. In addition, the administration of CEO or CE reverted back the activity of angiotensin converting enzyme (ACE) respectively in kidney and plasma. Interestingly, the CEO or CE inhibited lipase activity in small intestine by 48 and 42% which leads to the regulation of lipid profile. Moreover, the CEO or CE protected liver-kidney function evidenced by blood indices toxicity. In conclusion, our finding demonstrates that the administration of CEO or CE to diabetic rats can make it a potential strong candidate for industrial application as a pharmacological agent for the prevention and treatment of hyperglycemia, obesity and hypertension.

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Metabolic Changes of Active Components of Important Medicinal Plants on the basis of Traditional Chinese Medicine under Different Environmental Stresses

Shahrajabian

Kuang

Cui

et al. 2023

COC

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Introduction: Traditional Chinese medicine is an ancient system of wellness and health that has been used in almost all countries of the world, specially in Asia for thousands of years. Method: The growth, development, final yield and chemical compounds of medicinal plants can be negatively influenced by different kinds of biotic and abiotic stresses. Abiotic stress signals are chemical stress (Mineral salts, heavy metal, aerosols, gaseous toxins, pesticides, and pollutants), salinity (salt), temperature (Heat, cold), radiation (Ionisation radiation, light and UV), water (Flooding, drought) and mechanical stress (Submergence, wind, soil movement). Relevant literature has been obtained using the keywords “Traditional Chinese Medicine”, “Abiotic Stress”, “Biotic Stress”, “Ginseng”, “Ginger”, “Goji berry”, “Astragalus”, “Ginkgo”, “Artemisia annua L.”, “LC-MS”, “GC-MS”, and “NMR” in scientific information, namely “Web of Science”, “PubMed”, “SciFinder”, and “Elsevier”. Some of the plants’ secondary metabolites under different growth conditions are Camptothecin (Camptotheca acuminata), Capsaicin (Capsicum sp.), Rosmarinic acid (Salvia miltiorrhiza), Codeine (Papaver somniferum), Resveratrol (Grapes, groundnut), Artemisinin (Artemesia annua), Allicin (Allium sativum), Rohitukine (Dysoxylum binectariferum), Stevioside (Stevia rebaudiana), Andrographolide (Andrographis paniculata), Saikosaponins (Bupleurum chinense), Sennosides (Cassia augustifolia), Rutin (Dimorphandra mollis), Valepotriates (Valeria species), Indole alkaloids (Catharanthus roseous), and Furanocoumarins (Bituminaria bituminosa). Result: The aim of this article is a survey of active chemical compounds and metabolic changes of some of the most important medicinal plants in traditional Chinese medicine (TCM) in both abiotic and biotic stresses. Conclusion: Future research is needed to evaluate the effects of biotic and abiotic stresses on chemical compounds and active metabolites of medicinal plants specially traditional Chinese medicine, and more surveys on the roles of LC-MS, GC-MS and NMR techniques for a better understanding of chemical components of medicinal plants.

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The possible protective and therapeutic effects of ginger and cinnamon on the testis and coda epididymis of streptozotocin-induced-diabetic rats: Histological and biochemical studies

Cited by 4 publications

References 34 publications

The Effects of Methotrexate, Moringa oleifera Leaf Extract, and Andrographis paniculata Leaf Extract on the Testes of Hyperglycemic Wistar Rats

The Effects of Methotrexate, Moringa oleifera Leaf Extract, and Andrographis paniculata Leaf Extract on the Testes of Hyperglycemic Wistar Rats

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Metabolic Changes of Active Components of Important Medicinal Plants on the basis of Traditional Chinese Medicine under Different Environmental Stresses

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