The Postoperative Antiemetic Effect of Midazolam in Patients Undergoing Appendectomy

Cho, Sang Yoon; Oh, Mi Kyung; Yeom, Jong Hoon; Shin, Woo Jong; Kim, Yong Chul; Lee, Dong Hoon

doi:10.4097/kjae.1999.37.6.1095

Cited by 3 publications

(2 citation statements)

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“…It was recently reported that midazolam, a benzodiazepine used for pretreatment to reduce preanesthetic anxiety, reduced the frequency and intensity of PONV, showing a sedative effect as well as an antiemetic effect [ 6 , 7 ]. Midazolam has been used in many different ways to prevent PONV.…”

Section: Introductionmentioning

confidence: 99%

The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

Kim

Koo

Kang

et al. 2012

Korean J Anesthesiol

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BackgroundWe made a comparative study on the antiemetic effect of midazolam and ondansetron added to intravenous patient-controlled analgesia (PCA) using fentanyl with gynecologic patients undergoing pelviscopic surgery.MethodsThe PCA using 20 µg/kg of fentanyl was started in all groups postoperatively. A dose of 16 mg of ondansetron was added to the PCA of group O (n = 30). A dose of 5 mg of midazolam was added to the PCA of group M (n = 30). While 16 mg of ondansetron and 5 mg of midazolam were added to the PCA of group MO (n = 30). Total volume of the PCA was 60 ml, and the PCA system was programmed to deliver 0.5 ml/h of continuous doses and a 0.5 ml bolus on demand, with a 15 minutes lockout interval. The incidence of postoperative nausea and vomiting (PONV), sedation score, visual analog scale (VAS) for pain, and rescue drug dose for PONV were investigated at the postanesthesia care unit (PACU), 6 hours, and 24 hours after recovery.ResultsThe incidence of PONV in group MO was significantly lower than in group O at PACU, 24 hours after recovery (P < 0.05). The sedation score and VAS pain score showed no differences among all groups.ConclusionsMidazolam added to PCA using fentanyl proved more effective than ondansetron in preventing PONV without adverse effects.

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Section: Introductionmentioning

confidence: 99%

The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

Kim

Koo

Kang

et al. 2012

Korean J Anesthesiol

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show abstract

“…[ 1 2 3 4 ] The incidence of PONV is varies from 14% to 82%. [ 2 3 5 7 26 27 ] The etiology of PONV is not completely known but from the present data showed that stimulation of four groups of receptors are effective in prevention of PONV. These receptors are: Cholinergic (muscarinic), dopaminergic (D2), histaminergic (H1) and seretoninergic (5HT3).…”

Section: Discussionmentioning

confidence: 73%

Geranisetron versus gabapentin in preventing postoperative nausea and vomiting after middle ear surgery in adults: A double-blinded randomized clinical trial study

et al. 2015

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Background:The incidence of postoperative nausea and vomiting (PONV) after middle ear surgery is high. In this study we want to compare the effects of intravenous granisetron and oral gabapentin as a premedication before surgery on the incidence and severity of PONV after middle ear surgery in adult patents.Materials and Methods:We enrolled 90 patients that were randomly divided into the three groups of 30 in each. Group I received granisetron 3 mg iv 2 minutes before induction of anesthesia; Group II received oral gabapentin 300 mg 1 hour before anesthesia and Group III received placebo. The incidence and severity of PONV were recorded each 15 minutes in the post-anesthesia care unit (PACU) and each 8 hours until 24 hours after discharge from the PACU.Result:The incidence and severity of nausea and vomiting at different time intervals in Groups I and Group II was significantly lower compared with Group III (P < 0.05). There was no significant difference in the incidence of side effects of study drug administration including respiratory depression, apnea, extra pyramidal disorders, drowsiness, dizziness, vertigo and headache in three groups.Conclusion:The study was shown that using gabapentin and granisetron have equal anti-emetic effects, but significant differences were seen between these two groups compared to the control group. These submit the efficiency of these drugs in preventing PONV.

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The effect of perioperative benzodiazepine administration on postoperative nausea and vomiting: a systematic review and meta-analysis of randomised controlled trials

Au,

Zhao,

Belley-Côté

et al. 2024

British Journal of Anaesthesia

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The Postoperative Antiemetic Effect of Midazolam in Patients Undergoing Appendectomy

Cited by 3 publications

References 0 publications

The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

Geranisetron versus gabapentin in preventing postoperative nausea and vomiting after middle ear surgery in adults: A double-blinded randomized clinical trial study

The effect of perioperative benzodiazepine administration on postoperative nausea and vomiting: a systematic review and meta-analysis of randomised controlled trials

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