The Potential Advantages of Lipid Nanoparticles in Treatment of Acne

Abstract

Acne is a disfiguring disorder of the skin with significant cosmetic morbidity that may lead to serious psychological and social dysfunction. The skin disease comes in two forms. The most well-known form is Acne vulgaris (referred to as acne), which mostly manifests in teens but may continue into the early 20s. The second form is called Acne rosacea (referred to as rosacea) and mostly affects 30- to 60-year-olds. The two forms, despite sharing a common prefix, are quite unrelated in their respective pathophysiology, have different approaches to treatment and hence are considered two separate conditions. The conventional drug delivery system is efficient in the management of acne but poor patient compliance and adverse effects limit its efficacy. Lipid nanoparticles are novel nano lipid carriers made from biocompatible lipid which reduces toxicity; improve physical stability, skin hydration, and film formation. Furthermore, lipid nanoparticles protect the encapsulated drug from degradation. Thus current review focused on the potential use of lipid nanoparticles for the management of acne.

Recent advances for commedonal acne treatment by employing lipid nanocarriers topically

“…Topical therapy is the first-line treatment used for mild and moderate acne. Topical treatments base on antibiotics, acids, benzoyl peroxide, retinoids, herbal agents or a combination of topical drugs (6). Although topical treatments are safer than systemic, it has many adverse effects.…”

“…Nanotechnological carriers have essential advantages over conventional treatments which overcome their undesired effects and address other challenges as following: ➢ Take role in photothermal and photodynamic therapy of acne as through ruining antibiotic resistant bacteria that cause acne Besides particles size, lipophilicity of the nanocarrier plays important role in delivering the drug to the target site by helping crossing the stratum corneum and forming a drug reservoir in the hair follicles. Thus, lipid based nanocarriers are most suitable for topical therapy (6). Lipid nanoparticles are novel nanolipid carriers made from biocompatible lipid which reduces toxicity; improve physical stability, skin hydration (due to their occlusive nature, they form a thin patch on skin surface thus reducing trans epidermal water loss) which facilitates topical penetration.…”

“…Lipid nanoparticles are novel nanolipid carriers made from biocompatible lipid which reduces toxicity; improve physical stability, skin hydration (due to their occlusive nature, they form a thin patch on skin surface thus reducing trans epidermal water loss) which facilitates topical penetration. Also, the lipid nanoparticles shield the encapsulated drug from degradation (6). Lipid nanocarriers refer to a large panel of drug delivery systems.…”

“…Other external factors, termed as "exposomes", such as environmental factors, dietetic factors, emotional factors and various drug therapies, largely influence the incidence, duration and severity of acne (4). Most of the conventional formulations produce side effects that diminish the patient compliance (6). Systemic utilization drugs can be accompanied with unwanted toxicities.…”

“…Nano-carrier based drug delivery reduces irritancy of drugs and improves penetration of drug into the hair follicles. The antiacne therapeutics loadedlipid particulate system for topical application is more preferable compared to conventional available topical delivery system (6).Hence, nanocarriers used for topical drug-delivery strategies have gained interest in recent years. Dermal drug delivery via lipid-based nanocarriers (solid-lipid nanoparticles and nanostructured lipid carriers, vesicular nanocarriers including oleic acid vesicles, niosomes, transethosomes and spanlastics and microemulsions have been widely investigated.…”