The Potential Contribution of microRNAs in Anti-cancer Effects of Aurora Kinase Inhibitor (AZD1152-HQPA)

Zekri, Ali; Mesbahi, Yashar; Boustanipour, Elham; Sadr, Zahra; Ghaffari, Seyed H.

doi:10.1007/s12031-018-1118-y

Cited by 6 publications

(4 citation statements)

References 52 publications

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“…AURKB, a crucial regulator of malignant mitosis, is involved in chromosome segregation and cytokinesis. upregulated miRNAs (miR-203/138/18b/363/1/ 133b/373) are known to have tumor and metastatic suppressor functions and associated with cell apoptosis and cycle arrest, as well as inhibition of angiogenesis, invasion, and metastasis (Zekri, Mesbahi, Boustanipour, Sadr, & Ghaffari, 2018). miRNA, was downregulated in cervical cancer tissue and miR-374b analog in cervical cancer cell lines showed significantly inhibition of cell proliferation, migration, and invasion through the blockade of the p38/ERK signaling pathway (Li et al, 2018).…”

Section: Cancermentioning

confidence: 99%

Section: Cancermentioning

confidence: 99%

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An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

Saliminejad

Khorshid

Fard

et al. 2018

Journal Cellular Physiology

1,405

830

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MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and currently miRNA-mediated clinical trial has shown promising results for treatment of cancer and viral infection. This review provides an overview and update on miRNAs biogenesis, regulation of miRNAs expression, their biological functions, and role of miRNAs in epigenetics and cell-cell communication. In addition, alteration of miRNAs following exercise, their associationwith diseases, and therapeutic potential will be explained. Finally, miRNA bioinformatics tools and conventional methods for miRNA detection and quantification will be discussed.

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Section: Cancermentioning

confidence: 99%

Section: Cancermentioning

confidence: 99%

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

Saliminejad

Khorshid

Fard

et al. 2018

Journal Cellular Physiology

1,405

830

View full text Add to dashboard Cite

show abstract

“…Zekri et al reported that barasertib has antiproliferative and antitumor effects in NB models. In NB cells, the compound upregulates a relevant number of cancer-related miRNA that are tumor suppressors involved in angiogenesis, cell invasion, and metastasis, while it downregulates two miRNA with oncogenic activity [ 80 ].…”

Section: Stk Inhibitorsmentioning

confidence: 99%

Synthetic Heterocyclic Derivatives as Kinase Inhibitors Tested for the Treatment of Neuroblastoma

et al. 2021

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In the last few years, small molecules endowed with different heterocyclic scaffolds have been developed as kinase inhibitors. Some of them are being tested at preclinical or clinical levels for the potential treatment of neuroblastoma (NB). This disease is the most common extracranial solid tumor in childhood and is responsible for 10% to 15% of pediatric cancer deaths. Despite the availability of some treatments, including the use of very toxic cytotoxic chemotherapeutic agents, high-risk (HR)-NB patients still have a poor prognosis and a survival rate below 50%. For these reasons, new pharmacological options are urgently needed. This review focuses on synthetic heterocyclic compounds published in the last five years, which showed at least some activity on this severe disease and act as kinase inhibitors. The specific mechanism of action, selectivity, and biological activity of these drug candidates are described, when established. Moreover, the most remarkable clinical trials are reported. Importantly, kinase inhibitors approved for other diseases have shown to be active and endowed with lower toxicity compared to conventional cytotoxic agents. The data collected in this article can be particularly useful for the researchers working in this area.

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“…Some miRNAs are associated with cancer growth, while others are tumor suppressors. Zekri et al (2018) found that cells from neuroblastoma treated with compound 19 increased tumor suppressor miRNA production, whereas they decreased production of oncogenic miRNAs [ 202 ]. However, compound 19 has not found any use in clinical practice, yet.…”

Section: Aurora Kinases Inhibitorsmentioning

confidence: 99%

Mitotic Poisons in Research and Medicine

et al. 2020

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Cancer is one of the greatest challenges of the modern medicine. Although much effort has been made in the development of novel cancer therapeutics, it still remains one of the most common causes of human death in the world, mainly in low and middle-income countries. According to the World Health Organization (WHO), cancer treatment services are not available in more then 70% of low-income countries (90% of high-income countries have them available), and also approximately 70% of cancer deaths are reported in low-income countries. Various approaches on how to combat cancer diseases have since been described, targeting cell division being among them. The so-called mitotic poisons are one of the cornerstones in cancer therapies. The idea that cancer cells usually divide almost uncontrolled and far more rapidly than normal cells have led us to think about such compounds that would take advantage of this difference and target the division of such cells. Many groups of such compounds with different modes of action have been reported so far. In this review article, the main approaches on how to target cancer cell mitosis are described, involving microtubule inhibition, targeting aurora and polo-like kinases and kinesins inhibition. The main representatives of all groups of compounds are discussed and attention has also been paid to the presence and future of the clinical use of these compounds as well as their novel derivatives, reviewing the finished and ongoing clinical trials.

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The Potential Contribution of microRNAs in Anti-cancer Effects of Aurora Kinase Inhibitor (AZD1152-HQPA)

Cited by 6 publications

References 52 publications

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

Synthetic Heterocyclic Derivatives as Kinase Inhibitors Tested for the Treatment of Neuroblastoma

Mitotic Poisons in Research and Medicine

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