2015
DOI: 10.3390/nu7064271
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The Potential for Zinc Stable Isotope Techniques and Modelling to Determine Optimal Zinc Supplementation

Abstract: It is well recognised that zinc deficiency is a major global public health issue, particularly in young children in low-income countries with diarrhoea and environmental enteropathy. Zinc supplementation is regarded as a powerful tool to correct zinc deficiency as well as to treat a variety of physiologic and pathologic conditions. However, the dose and frequency of its use as well as the choice of zinc salt are not clearly defined regardless of whether it is used to treat a disease or correct a nutritional de… Show more

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Cited by 16 publications
(9 citation statements)
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References 167 publications
(249 reference statements)
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“…Zinc absorption and bioavailability in humans is mostly analyzed with (stable) isotope tracer techniques, primarily measuring fractional zinc absorption [315]. In earlier studies, the zinc radioisotope 65 Zn was also used to investigate zinc homeostasis [316] and bioavailability in humans [317], but is currently replaced by non-radioactive and stable isotopes [318] and solely employed in vitro [66,71,79].…”
Section: Analytical Approaches To Studying In Vitro Zinc Absorption Amentioning
confidence: 99%
“…Zinc absorption and bioavailability in humans is mostly analyzed with (stable) isotope tracer techniques, primarily measuring fractional zinc absorption [315]. In earlier studies, the zinc radioisotope 65 Zn was also used to investigate zinc homeostasis [316] and bioavailability in humans [317], but is currently replaced by non-radioactive and stable isotopes [318] and solely employed in vitro [66,71,79].…”
Section: Analytical Approaches To Studying In Vitro Zinc Absorption Amentioning
confidence: 99%
“…Radioisotopes are a decent diagnostic tool, but they are costly. New biomarkers such as Linoleic Acid are emerging [54][55][56][57] . However, considering the vast population involved with SARS-CoV-2 and the high economic Burdon of such approaches, we propose a simple and cheap method to select zinc-deficient SARS-CoV-2 patients and include zinc correction in their treatment package.…”
Section: Practicalitymentioning
confidence: 99%
“…To date, there are no isotopic methods used to evaluate iron status. The utility of monitoring the size of the exchangeable zinc pool (EZP) to reflect changes in zinc intake or absorption has been investigated ( 22 ).…”
Section: Current Status Of Knowledgementioning
confidence: 99%
“…The ratio of the 2 isotopes in urine (or plasma can be used) is examined after an appropriate mixing time ( Figure 6 ). After correcting for dose size and enrichment, fractional absorbed zinc and total zinc absorption from the test meal can be determined ( 22 ). For example, a zinc-absorption study provided women with typical wheat and zinc-biofortified wheat tortillas containing different zinc isotopes ( 67 Zn and 70 Zn), and compared the enrichment in urine with an intravenous dose of 68 Zn [ Figure 6 ( 104 † )].…”
Section: Current Status Of Knowledgementioning
confidence: 99%
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