The Potential Importance of MicroRNAs as Novel Indicators How to Manage Patients with Juvenile Idiopathic Arthritis More Effectively

Orczyk, Krzysztof; Smolewska, Elżbieta

doi:10.1155/2021/9473508

Cited by 9 publications

(5 citation statements)

References 96 publications

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“…In particular, we focused on the clinical characteristics of JIA patients (subtypes, disease activity, and therapies), the type of biological samples used in the different studies, and the biological characteristics of the miRNAs analyzed (free or EV-derived). The comparison between data obtained in JIA vs. adult arthritides, as well as miRNA role in JIA pathogenesis, which have been previously reviewed by others [19,112], was not further addressed here. Finally, we summarized data in the literature highlighting the relevance of miRNAs as therapeutic biomarkers in patients affected by chronic inflammatory rheumatic conditions other than JIA to emphasize the need for future research in JIA aimed at assessing miRNA potential value as predictors of responses to therapies for clinical applications in this disease.…”

Section: Mirnas In Jia: General Considerationsmentioning

confidence: 99%

MicroRNAs in Juvenile Idiopathic Arthritis: State of the Art and Future Perspectives

Pelassa

Raggi

Rossi

et al. 2023

Biology

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Juvenile Idiopathic Arthritis (JIA) represents the most common chronic pediatric arthritis in Western countries and a leading cause of disability in children. Despite recent clinical achievements, patient management is still hindered by a lack of diagnostic/prognostic biomarkers and targeted treatment protocols. MicroRNAs (miRNAs) are short non-coding RNAs playing a key role in gene regulation, and their involvement in many pathologies has been widely reported in the literature. In recent decades, miRNA’s contribution to the regulation of the immune system and the pathogenesis of autoimmune diseases has been demonstrated. Furthermore, miRNAs isolated from patients’ biological samples are currently under investigation for their potential as novel biomarkers. This review aims to provide an overview of the state of the art on miRNA investigation in JIA. The literature addressing the expression of miRNAs in different types of biological samples isolated from JIA patients was reviewed, focusing in particular on their potential application as diagnostic/prognostic biomarkers. The role of miRNAs in the regulation of immune responses in affected joints will also be discussed along with their potential utility as markers of patients’ responses to therapeutic approaches. This information will be of value to investigators in the field of pediatric rheumatology, encouraging further research to increase our knowledge of miRNAs’ potential for future clinical applications in JIA.

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Section: Mirnas In Jia: General Considerationsmentioning

confidence: 99%

MicroRNAs in Juvenile Idiopathic Arthritis: State of the Art and Future Perspectives

Pelassa

Raggi

Rossi

et al. 2023

Biology

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“…Certain de ces miARN jouent un rôle important dans la régulation immunitaire (maturation et différenciation des lymphocytes T, des monocytes, polarisation des macrophage et des lymphocytes T en lymphocytes Th17, etc. ), renforçant l'hypothèse de leur implication dans cette maladie inflammatoire [27,29]. Cependant, la plupart de ces études n'ont portées que sur un nombre restreint de miARN.…”

Section: Les Micro-arn Et L'ajiunclassified

Microbiote et miARN intestinaux

2023

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L’arthrite juvénile idiopathique (AJI) est une maladie inflammatoire chronique caractérisée par la présence d’une ou plusieurs arthrites (inflammations des articulations) chez l’enfant. Les mécanismes exacts responsables de son développement restent inconnus. Pour de nombreuses maladies inflammatoires, un dialogue altéré entre le microbiote intestinal et son hôte est un élément clé de leur physiopathologie. Les micro-ARN (miARN) fécaux, de petits ARN non codants synthétisés par l’hôte que l’on retrouve dans les fèces, semblent jouer un rôle important dans ce dialogue. Dans l’AJI, si la présence d’une dysbiose et d’une modification du profil des miARN présents dans le sang, dans les cellules et les articulations ont été établies, les spécificités des miARN fécaux des patients n’ont pas été étudiées. Nous discutons, dans cette revue, l’intérêt d’une étude concomitante des miARN fécaux et du microbiote intestinal ches les patients atteints d’AJI, un concept qui apparaît essentiel pour la compréhension de la physiopathologie de cette maladie.

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“…However, juvenile idiopathic arthritis will also occur in a high proportion, which is very detrimental to the growth of children [ 82 ]. The study has shown that miR-23b helps in the diagnosis and monitoring of RA [ 83 ]. miR-23b is negatively related to inflammation in RA [ 47 ].…”

Section: The Role Of Mir-23b In Autoimmune Diseasementioning

confidence: 99%

The Role of miR-23b in Cancer and Autoimmune Disease

Guo

Wang

et al. 2021

Journal of Oncology

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Short-stranded miRNAs are single-stranded RNA molecules involved in the regulation of gene expression. miRNAs are involved in a variety of cellular physiological processes, including cell proliferation, differentiation, and apoptosis. miR-23b have been identified to act both as oncogenes and as tumor suppressors. In addition, miR-23b is related to inflammation resistance to various autoimmune diseases and restrained inflammatory cell migration. The characterization of the specific alterations in the patterns of miR-23b expression in cancer and autoimmune disease has great potential for identifying biomarkers for early disease diagnosis, as well as for potential therapeutic intervention in various diseases. In this review, we summarize the ever-expanding role of miR-23b and its target genes in different models and offer insight into how this multifunctional miRNA modulates tumor cell proliferation and apoptosis or inflammatory cell activation, differentiation, and migration.

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The Potential Importance of MicroRNAs as Novel Indicators How to Manage Patients with Juvenile Idiopathic Arthritis More Effectively

Cited by 9 publications

References 96 publications

MicroRNAs in Juvenile Idiopathic Arthritis: State of the Art and Future Perspectives

MicroRNAs in Juvenile Idiopathic Arthritis: State of the Art and Future Perspectives

Microbiote et miARN intestinaux

The Role of miR-23b in Cancer and Autoimmune Disease

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