The potential of adipokines as biomarkers and therapeutic agents for vascular complications in type 2 diabetes mellitus

Liang, Wei; Ye, Dong dong

doi:10.1016/j.cytogfr.2019.06.002

Cited by 57 publications

(39 citation statements)

References 94 publications

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“…It is responsible for the endothelial dysfunction that may cause progression of atherosclerosis. So, it becomes a risk factor for cardiovascular diseases (Liang and Ye 2019;Ragino et al 2020;Landecho et al 2019).…”

Section: Discussionmentioning

confidence: 99%

The effect of balneotherapy on body mass index, adipokine levels, sleep disturbances, and quality of life of women with morbid obesity

et al. 2020

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To investigate the effect of balneotherapy on body mass index, adipokine levels, sleep disturbances, and quality of life in women with morbid obesity. Fifty-four women with morbid obesity were included in the study. The body mass indexes (BMI) and waist/ hip ratios (WHR) of the women were calculated. Subcutaneous fat thickness was measured using a *skinfold meter, and the percentage of adipose tissue was calculated. The *Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality, and the Nottingham Health Profile (NHP) was used to assess quality of life. In addition to routine biochemical tests, leptin, adipokine, visfatin from blood, and cortisol from saliva samples were studied. Participants were given 15 sessions of balneotherapy for 20 min each. After treatment, the laboratory and clinical parameters of the participants were *reevaluated. There was no statistically significant difference of BMI, WHR, and percentage of adipose tissue between before and after treatment measurements (p ˃ 0.05).There was a statistically significant improvement in PSQI and NSP scores (p ˂ 0.001). The levels of blood glucose, leptin, and visfatin were significantly decreased, and adiponectin was significantly increased after treatment (p = 0.047, p ˂ 0.001, p ˂ 0.001, and p ˂ 0.001, respectively).There was no statistically significant changes in salivary cortisol levels (p = 0.848). Patients with diabetes showed a statistically significant decrease in glucose levels after treatment (p = 0.017).There was a statistically significant decrease in low-density lipoprotein cholesterol levels in patients with dyslipidemia compared with pretreatment (p = 0.018). Balneotherapy improves sleep and quality of life of women with morbid obesity. After balneotherapy, glucose, leptin, adiponectin, and visfatin levels may change positively.

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Section: Discussionmentioning

confidence: 99%

The effect of balneotherapy on body mass index, adipokine levels, sleep disturbances, and quality of life of women with morbid obesity

et al. 2020

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“…Omentin is encoded by two genes, known as omentin-1 and omentin-2, with the former being the major circulating form. Omentin-1 is mainly expressed in the stromal vascular cells of visceral adipose tissue that plays an anti-inflammatory, anti-oxidative, and insulin-sensitizer role [62]. In obesity, omentin-1 levels are decreased and are inversely correlated to BMI, waist circumference, and markers of metabolic syndrome.…”

Section: Specific Adipokinesmentioning

confidence: 99%

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

et al. 2019

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Obesity, which is a worldwide epidemic, confers increased risk for multiple serious conditions including type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular diseases. Adipose tissue is considered one of the largest endocrine organs in the body as well as an active tissue for cellular reactions and metabolic homeostasis rather than an inert tissue only for energy storage. The functional pleiotropism of adipose tissue relies on its ability to synthesize and release a large number of hormones, cytokines, extracellular matrix proteins, and growth and vasoactive factors, which are collectively called adipokines known to influence a variety of physiological and pathophysiological processes. In the obese state, excessive visceral fat accumulation causes adipose tissue dysfunctionality that strongly contributes to the onset of obesity-related comorbidities. The mechanisms underlying adipose tissue dysfunction include adipocyte hypertrophy and hyperplasia, increased inflammation, impaired extracellular matrix remodeling, and fibrosis together with an altered secretion of adipokines. This review describes the relevance of specific adipokines in the obesity-associated cardiovascular disease.

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“…Various adipocytokines and proinflammatory cytokines, including resistin, can deteriorate in obesityrelated disorders, including insulin resistance, type 2 diabetes, atherosclerosis, and coronary artery disease (CAD) [1,2]. Resistin is primarily known as a hormone secreted by adipocytes primarily in rodents, while it is mainly expressed by macrophages in humans [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Elevated resistin contributes to the formation of atherosclerosis through not only its indirect influences on the exacerbation of risk factors, such as insulin resistance, atherogenic dyslipidaemia, and hypertension, but also its direct effects on key steps of atherosclerosis [5]. Some experimental studies have indicated that resistin regulates the progression of atherosclerosis via inducing endothelial dysfunction, the artery inflammatory response, and the formation of foam cells in human macrophages [1,2,5]. Additionally, clinical research with a large sample size also indicated that serum resistin may act as a risk factor for coronary disease in the general population, especially in women [11].…”

Section: Introductionmentioning

confidence: 99%

Significant association between serum resistin and hypersensitive troponin I levels in patients with a first ST-segment elevation myocardial infarction

Zhu

Liu

et al. 2019

Preprint

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Background Resistin, a proinflammatory adipocytokine secreted predominately by macrophages in humans, plays an important role in the pathogenesis and development of atherosclerosis. The present research mainly investigated the association between serum resistin level and peak hypersensitive cardiac troponin I (hs-cTnI) in patients with ST-segment elevation myocardial infarction (STEMI).Methods We consecutively enrolled 92 patients with a first STEMI in this cross-sectional and observational study. Resistin concentrations upon admission and 24 h and 72 h after primary percutaneous coronary intervention (PCI) were all measured. The change in resistin (δ Resistin) was defined as (serum resistin concentration at admission)-(serum resistin concentration 24 h after intervention).Results Serum resistin concentration decreased rapidly after primary PCI. Resistin at admission correlated positively with tumour necrosis factor-α (r = 0.522, p<0.001) and macrophage migration inhibitory factor (r = 0.471, p<0.001). Additionally, resistin at admission correlated negatively with the reactive oxygen species scavengers superoxide dismutase (r = -0.261, p = 0.012) and glutathione peroxidase (r = -0.235, p = 0.024). Most importantly, serum resistin concentrations upon admission (r = 0.381, p<0.001) and 24 h (r = 0.372, p<0.001) and 72 h (r = 0.347, p = 0.001) after primary PCI all correlated with peak hs-cTnI, while δ Resistin was not associated with peak hs-cTnI. After multiple linear regression analysis, serum resistin (beta = 13.593, 95% CI 5.951 to 21.235, p < 0.001) at admission and 24 h (beta = 13.972, 95% CI 5.662 to 22.282, p = 0.001) and 72 h (beta = 14.455, 95% CI 5.178 to 23.733, p = 0.003) after intervention remained associated with peak hs-cTnI.Conclusions In our present research, serum resistin concentrations at different time points all correlated positively with peak hs-cTnI, which may suggest that serum resistin concentrations during the acute phase of STEMI are useful for forecasting myocardial infarction size and prognosis in patients after primary PCI. Additionally, our research also indicated that resistin may regulate myocardial IRI partly by promoting the inflammatory process and oxidative stress.

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The potential of adipokines as biomarkers and therapeutic agents for vascular complications in type 2 diabetes mellitus

Cited by 57 publications

References 94 publications

The effect of balneotherapy on body mass index, adipokine levels, sleep disturbances, and quality of life of women with morbid obesity

The effect of balneotherapy on body mass index, adipokine levels, sleep disturbances, and quality of life of women with morbid obesity

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

Significant association between serum resistin and hypersensitive troponin I levels in patients with a first ST-segment elevation myocardial infarction

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