The Potentizing Effect of Antimolding Agents in Syrups*

Littlejohn, Oliver M.; Husa, William J.

doi:10.1002/jps.3030440514

Cited by 7 publications

(5 citation statements)

References 1 publication

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“…Potentizing Action of Mixtures of p-Hydroxybenzoate%-Several investigators (4,5) have suggested the use of mixtures of the p-hydroxybenzoates and have demonstrated an increase in activity when mixtures were employed. Since many of these reports are lacking in details, a comprehensive study of this potentizing action was undertaken.…”

mentioning

confidence: 99%

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The Effect of Various Preservatives on Microorganisms Isolated from Deteriorated Syrups

Schimmel

Husa

1956

Journal of the American Pharmaceutical Association (Scientific

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confidence: 99%

“…Throughout this study, the term "potentizing action" denotes the increased effect which occurs when a mixture of two or more preservatives has a greater apparent preservative action than the sum of the effects of the preservatives when used alone. The calculation of potentizing action is the same as that employed by Littlejohn and Husa (4).…”

mentioning

confidence: 99%

The Effect of Various Preservatives on Microorganisms Isolated from Deteriorated Syrups

Schimmel

Husa

1956

Journal of the American Pharmaceutical Association (Scientific

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“…16 Accordingly, it was recommended to use a mixture of paraben derivatives in order to obtain a more efficient preservative. 17 Physically, paraben is white crystals with no odor or distinguished taste for a concentration of less than 0.08%, higher concentrations have a metallic strong taste. 18 Therefore, its use in food products is limited to the mentioned concentration.…”

Section: Physiochemical Properties Of Parabenmentioning

confidence: 99%

“…For example, antifungal properties are linked to those with longer alkyl chains 16 . Accordingly, it was recommended to use a mixture of paraben derivatives in order to obtain a more efficient preservative 17 …”

Section: Introductionmentioning

confidence: 99%

Implication of parabens in cosmetics and cosmeceuticals: Advantages and limitations

Al-Halaseh

Al‐Adaileh

Mbaideen

et al. 2022

J of Cosmetic Dermatology

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Cosmetics, cosmeceuticals, and variable healthcare products used parabens, among other excipients, for their preservative and antimicrobial activities. Paraben derivatives exhibit distinguished physiochemical properties that enable them to be compatible with the formulation of cosmetic agents in different dosage forms. In addition to their potency and efficacy, parabens are economically efficient as they have low‐manufacturing costs. Despite the desirable characteristics, the safety of parabens use is controversial after detecting these chemicals in various biological tissues after repetitive and long‐term use of formulations containing them. The use of parabens drew public health attention after scientific reports linked skin exposure to parabens with health issues, in particular, breast cancer. In response, worldwide authorities set regulations for the allowance concentrations of paraben to be used in variable cosmetic products.

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“…Different types of parabens are different in their functions and applications. Longer alkyl chain parabens have stronger effect on plant pathogenic fungi [2], and mixtures of the parabens show more effective of preservative than each individual paraben [3]. These parabens exist in some fruits and vegetables in nature, but most of them are synthesized from hydroxyl benzoic acid during industrial-scale process, and then modified for various types of our daily products.…”

Section: Introductionmentioning

confidence: 99%

Review on Life Cycle of Parabens: Synthesis, Degradation, Characterization and Safety Analysis

Yang

Zhang

2018

COC

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In this review, we show the life cycle of parabens, commonly used preservatives that exist in nature and commercial products. Typical synthetic methods to produce parabens, and a set of complimentary characterization techniques to monitor the composition of parabens are also highlighted. These includes solid state analysis using Scanning Electron Microscope (SEM), Differential Scanning Calorimetry (DSC) and X-Ray Diffraction (XRD), in-situ monitoring of crystallization process using Focused Beam Reflectance Measurement (FBRM), Particle Vision Measurement (PVM), quantitative detection via High Performance Liquid Chromatography (HPLC), and Gas Chromatography (GC). An improved understanding of the overall physical, biophysical and chemical properties of parabens and their life cycle, summarized in this article, are vital for the safety control and extensive applications of relevant products in food, cosmetic and pharmaceutical industries.

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The Potentizing Effect of Antimolding Agents in Syrups*

Cited by 7 publications

References 1 publication

The Effect of Various Preservatives on Microorganisms Isolated from Deteriorated Syrups

The Effect of Various Preservatives on Microorganisms Isolated from Deteriorated Syrups

Implication of parabens in cosmetics and cosmeceuticals: Advantages and limitations

Review on Life Cycle of Parabens: Synthesis, Degradation, Characterization and Safety Analysis

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