The predictive value of pregnancy-specific β1-glycoprotein (SP1) in threatened abortion

Schultz-Larsen, Peter; Hertz, J. B.

doi:10.1016/0028-2243(78)90074-6

Cited by 21 publications

(8 citation statements)

References 12 publications

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“…SP, is produced from the earliest stage of pregnancy . It may be that its main function is exercised at an early stage of pregnancy and that it is best employed as a placental function test in conditions like threatened abortion (Schultz-Larsen and Hertz, 1978). Gordon et al(1977) were more optimistic about SP, measurements in retarded fetal growth and it may be that a larger series will show more definite changes.…”

Section: Discussionmentioning

confidence: 99%

Tests of Fetal Wellbeing in the Third Trimester of Pregnancy

Hughes¹,

Bischof²,

Wilson³

et al. 1980

BJOG

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Summary Five different products secreted by the fetoplacental unit into the maternal circulation were measured in 272 patients when they were 34 weeks pregnant. The most useful indicator of present pathology or future complications of pregnancy was a placental protein, pregnancy associated plasma protein A which was raised in pre‐eclamptic toxaemia, antepartum haemorrhage and premature labour. The highest values were recorded in pre‐eclampsia before any signs of the disease were evident. Schwangerschafts protein 1 was also raised in pre‐eclampsia and antepartum haemorrhage but only after the disease had presented. Placental lactogen was also raised in pre‐eclampsia and its measurement may have some predictive value. Total oestriol was lowered in fetal growth retardation and the unconjugated steroid raised in pre‐eclampsia and lowered in retarded fetal growth.

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Section: Discussionmentioning

confidence: 99%

Tests of Fetal Wellbeing in the Third Trimester of Pregnancy

Hughes¹,

Bischof²,

Wilson³

et al. 1980

BJOG

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“…The concentration of SP1 in maternal serum (MSSP1) increases throughout pregnancy (Schultz-Larsen and Herz, 1978;Lenton et al, 1981) and it is a prognostic indicator in pregnancy complications (Brambati et al, 1991;Johnson et al, 1993). In Down syndrome (DS) pregnancies, elevated MSSP1 in the second trimes-ter has been described (Bartels and Lindemann, 1988;Wald et al, 1989;Knight et al, 1989;Bartels et al, 1990Bartels et al, , 1994Petrocik et al, 1990;Graham et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Schwangerschaftsprotein 1 (Sp1) as a Maternal Serum Marker for Down Syndrome in the First and Second Trimesters

et al. 1997

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“…Serum levels of hormones and proteins of fetal, placental and maternal origin have been used to predict the outcome in threatened abortion (Niven et al 1972;Nygren et al 1973 & Hertz 1978;Damber el ul. 1978;Jovanovic et al 1978;Joupilla el a/.…”

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confidence: 99%

Does ultrasound examination render biochemical tests obsolete in the prediction of early pregnancy failure?

Westergaard

Teisner²,

Sinosich

et al. 1985

BJOG

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Serum lcvels of fetal, placental and maternal hormones and proteins (u-fetoprotein (AFP), human chorionic gonadotrophin, human placentai lactogen. schwangerschaftsprotein 1, pregnancy associated plasma protein-A (PAPP-A), oestradiol-178, progesterone, pregnancy zone protein] were measured in 108 women with bleeding during the first half of pregnancy. Ultrasound examination at the time of each blood sampling revealed a fetal heart action on at least one occasion in 77 women. Spontaneous abortion occurred in 42 pregnancies, 31 of these showed no ultrasound sign of fetal life, whilst the fetal heart action was observed repeatedly until abortion in the remaining 11 women. Abnormally low levels of PAPP-A were most likely to indicate pregnancy failure, in particular if the fetal heart action was seen at the time of blood sampling. The predictive value, sensitivity and relative risk of a single depressed PAPP-A level were respectively 49, 89 and 41%, the predictive value of a normal result being 99%. With the exception of AFP, all other biochemical indices examined were consistently in the normal range in this group of women. If ultrasound findings were not considered, the biochemical indices were of comparable value in the prediction of spontaneous abortion. PAPP A levels were uniformly depressed in all patients who spontaneously aborted, frequently weeks before this event, in the presence of a live fetus.

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The predictive value of pregnancy-specific β1-glycoprotein (SP1) in threatened abortion

Cited by 21 publications

References 12 publications

Tests of Fetal Wellbeing in the Third Trimester of Pregnancy

Tests of Fetal Wellbeing in the Third Trimester of Pregnancy

Schwangerschaftsprotein 1 (Sp1) as a Maternal Serum Marker for Down Syndrome in the First and Second Trimesters

Does ultrasound examination render biochemical tests obsolete in the prediction of early pregnancy failure?

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