“…When a non-suppurative effusion is present, it varies quantitatively and qualitatively. Smallvolume, clinically unapparent effusions may be found at tympanocentesis [Paradise et al, 1976;Orchik et al, 1978;Fiellau-Nikolajsen, 1983;Karma et al, 1989;Toner and Mains, 1990;Babonis et al, 1991;Finitzo et al, 1992;Ovesen et al, 1993;Sassen et al, 1994;van Balen and de Melker, 1994;Watters et al, 1997]. In OME, effusions may be serous or mucoid [Carrie et al, 1992]; the former are mucin poor and associated with less inflammation in terms of immunoglobulin and cytokine levels [Chung et al, 2002;Yabe et al, 2008] and leucocyte infiltration [Tanaka et al, 1986;Yoon et al, 1990] (and are more often of shorter duration [Yoon et al, 1990], unilateral, and in an older age group [Giebink et al, 1982a, b]).…”