The prevalence and associations of sleep disturbances in patients with systemic lupus erythematosus

Abstract

The aim of this study was to analyze sleep complaints in patients with systemic lupus erythematosus (SLE) and to determine its prevalence and associations. Fifty outpatients with SLE and an equal number of age- and sex-matched controls were included in the study. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) in both cases and controls. Depressed mood, functional disability and pain severity were assessed in patients using standardized questionnaires. Disease severity, cumulative damage and presence of fibromyalgia were determined by clinical examination. Bivariate associations between sleep quality and disease-related variables as well as demographic variables were calculated. A series of hierarchical regression analyses were computed to determine the independent determinant of sleep quality. PSQI scores were significantly higher in patients with SLE. Prevalence of sleep disturbance was 62%. Functional disability, disease activity and depressed mood correlated positively with sleep disturbances. 36% of the patients satisfied ACR criteria for fibromyalgia. In multiple regression analyses disease activity was found to be an independent determinant of sleep quality. The prevalence of poor sleep quality in patients with SLE was higher than it is generally perceived to be. Functional disability, disease activity and depressed mood contributed significantly to sleep disturbances in SLE.

Acute Pain and Depressive Symptoms: Independent Predictors of Insomnia Symptoms among Adults with Sickle Cell Disease

“…In a qualitative study by Weisberg et al (2013), a participant with SCD was quoted as saying “And I would be scared to go to sleep, because I would think I was going to die in my sleep” suggesting sleep disturbances may arise from psychological stress (Weisberg et al, 2013). In addition, across studies disease severity and disease activity are consistently identified as risk factors for sleep problems among chronic disease populations (Chandrasekhara, Jayachandran, Rajasekhar, Thomas, & Narsimulu, 2009; Frech et al, 2011; Martínez De Lapiscina, Aguirre, Blanco, & Pascual, 2012). …”

High C-Reactive Protein Is Associated with Poor Sleep Quality Independent of Nocturnal Symptoms in Patients with Inflammatory Bowel Disease

“…Sleep problems are remarkably common in society and have been linked to a number of diseases and stressors including acute and chronic illness, physical and psychiatric disorders 10, 15–20 . In the context of IBD, recent work has suggested both depression and sleep impairment to be common, increase risk of relapses, and even precede a diagnosis of IBD 9–14 .…”

Qualidade do sono em pacientes com espondilite anquilosante

“…Além disso, as pontuaç ões do BASDAI que sugeriam doença ativa (≥ 4) estiveram significativamente associadas a escores maiores no PSQI (p < 0,001). A pontuação média do PSQI (3-6) foi de 4 nos pacientes com doença inativa e 8 (6,(8)(9)(10)(11)(12) nos pacientes com doença ativa. A análise detalhada de cada questão do BASDAI revelou que todas as questões se correlacionaram com os escores do PSQI (r = 0,453, p = 0,001 para Q1; r = 0,516, p < 0,001 para Q2; r = 0,431, p = 0,001 para Q3; r = 0,378, p = 0,005 para Q4; r = 0,457, p = 0,001 para Q5 e r = 0,442, p = 0,001 para Q6).…”

“…11 A compreensão da importância dos distúrbios do sono em pacientes com doenças reumáticas tem aumentado. 1,[12][13][14][15] Tal como na EA, mais da metade dos pacientes reumáti-cos relata distúrbios do sono. Considerando a qualidade de vida dos pacientes, é necessário compreender os componentes do sono perturbados e sua relação com os surtos da doença.…”