The prevalence and risk factors of atopic dermatitis in 6–8 year-old first graders in Taipei

Ho, Chi Kung; Chang, Lu-I; Wu, Wei

doi:10.1016/j.pedneo.2018.05.010

Cited by 13 publications

(12 citation statements)

References 30 publications

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“…Our multivariate analysis also revealed that Pohang-Si had higher odds ratios of AD and AR than Yeongdeok-Gun. In fact, several studies conducted in developed countries have shown a higher prevalence of allergic diseases [12,21,22,23,24], and in another, urban areas were found to be more prone to allergic diseases [25], which supports the argument that industrialization is associated with the higher prevalence of allergic diseases.…”

Section: Discussionmentioning

confidence: 64%

“…Views differ regarding whether age is a risk factor of allergic diseases [26,27]. One study [21] demonstrated a weak relation between age and allergic diseases, whereas another study [22] found a positive association. In the present study, those aged ≥19 had higher odds for AD and AR, possibly because our subjects were more exposed to allergens because this population may be more ambulatory, socio-economically active and might encounter more chances of being exposed to allergens during work and travel compared to the lower age group population.…”

Section: Discussionmentioning

confidence: 99%

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Factors Associated with Atopic Dermatitis and Allergic Rhinitis among Residents of Two Municipal Areas in South Korea

2019

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Background and Objectives: The growing burden and deleterious health consequences of allergic diseases, especially of allergic rhinitis (AR) and atopic dermatitis (AD), in developed countries remains an important public health issue. The current study aimed to assess the prevalence and to identify the risk factors of atopic dermatitis and allergic rhinitis among residents of Pohang-Si and Yeongdeok-Gun, two municipal areas in South Korea. Materials and Methods: A cross-sectional study was conducted in both municipal areas between 12 November and 13 December 2017. A total of 302 subjects were recruited from 100 households (25 apartments and 25 houses in each municipality), by system extraction according to district code numbers. Data were collected using International Study of Asthma and Allergies in Childhood (ISAAC) Standard Questionnaires for children and a health questionnaire for adults. Risk factors were identified by multivariate logistic regression analysis. Results: Of the 302 study participants, 12.9% and 25.5% had AD and AR, respectively. The significant factors associated with AD by multivariate logistic regression analysis were age ≥19 years (aOR (adjusted odds ratio) 6.9; 95% CI (confidence interval) (2.9–16.37)), residence in Pohang-Si (aOR 2.5; 95% CI (1.18–5.53)), and family history of allergic disease (aOR 2.3; 95% CI (1.09–4.9)). Similarly, the significant factors associated with AR were male gender (aOR 2.3; 95% CI (1.24–4.42)), age ≥19 years (aOR 4.4; 95% CI (2.28–8.48)), residence in Pohang-Si (aOR 2.8; 95% CI (1.51–5.37)), and family history of allergic disease (aOR 6.7; 95% CI (3.50–12.82)). Conclusion: The present study shows that age ≥19 years, residence in Pohang-Si, and family history of allergic disease are risk factors for AD and AR, and that, additionally, male gender is a risk factor of AR. Understanding the risk factors of allergic diseases can aid the design and implementation of evidence-specific strategies to reduce the long-standing problems associated with allergic disease.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Factors Associated with Atopic Dermatitis and Allergic Rhinitis among Residents of Two Municipal Areas in South Korea

2019

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“…RNN/5/15/KE. czynniki, jak brak zachorowania na zapalenie oskrzelików przed ukończeniem 2. roku życia, prawidłowe stosowanie antybiotyków u niemowląt i porady dietetyczne dla matek karmiących piersią [7]. W patogenezie AZS mutacje w genach kodujących białka strukturalne warstwy rogowej naskórka wpływają na funkcję bariery naskórkowej, natomiast stan zapalny rozwija się jako skutek kaskady cytokinowej związanej ze zmianami bariery [8].…”

Section: Methodsunclassified

“…Dermatology Review/Przegląd Dermatologiczny 2019/3 breastfeeding mothers may be good prevention strategies of AD [7]. In the pathogenesis of AD mutations in genes encoding stratum corneum structural proteins impact epidermal barrier function, while inflammation emerges as a downstream consequence of a sustained, barrier-driven cytokine cascade [8].…”

Section: Wprowadzeniementioning

confidence: 99%

Allergen-specific immunoglobulin E and interleukin 33 in atopic dermatitis

Bernacka¹,

Liszewska²,

Robak³

et al. 2019

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Introduction. The pathogenesis of atopic dermatitis includes genetic predisposition, epidermal barrier dysfunction, immunologic abnormalities and increased immunoglobulin E levels in some of the patients. Objective. Determination the allergen-specific immunoglobulin E level and serum interleukin-33 concentration in patients with atopic dermatitis. Material and methods. The study included 62 patients with atopic dermatitis at the mean age of 30.4 ±11.6 years. Clinical eveluation of the SCORAD index and the objective SCORAD (oSCORAD) was performed. Serum samples were analyzed for immunoglobulin E specific allergy using immunoblot kits for 21 allergens of atopy. Serum concentration of interleukin-33 was examined by ELISA. Results. The SCORAD index was higher (p < 0.05) in atopic dermatitis patients with immunoglobulin E specific to birch, dog fur, horse fur, Cladosporium herbarum, egg white, hazelnut, carrot, and potato than in those without such allergen-specific immunoglobulin E. Objective SCORAD was increased (p < 0.05) in atopic dermatitis patients with immunoglobulin E specific to birch, dog fur, Cladosporium herbarum, egg white, hazelnut, carrot, and potato in comparison to those without such allergen-specific immunoglobulin E. Mean serum concentration of interleukin-33 in patients with atopic dermatitis was 4.9 ±8.12 pg/ml. Serum interleukin-33 level did not correlate with such clinical parameters as the extent of skin lesions, pruritus, sleep disorders, SCORAD index and objective SCORAD. Interleukin-33 level was not higher in atopic dermatitis patients with immunoglobulin E specific to any examined antigen in comparison to those without such immunoglobulin E. Conclusions. Our study suggests that interleukin-33 is not a reliable marker of activity in atopic dermatitis. Further studies are necessary to confirm this hypothesis. StRESzczEniE Wprowadzenie. Patogeneza atopowego zapalenia skóry obejmuje predyspozycje genetyczne, dysfunkcję bariery naskórkowej, nieprawidłowości immunologiczne oraz podwyższony poziom immunoglobulin E u części pacjentów.

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“…In Taiwan, 24,999 Taiwanese children between 6–8-years of age were studied. The reported AD period prevalence within the time period of 2007 to 2008 was 10.7% [ 75 ]. Lin et al conducted a study among 74,688 junior high school students within the age range of 13 to 15 years old, which gave a prevalence of 7.6% [ 48 ].…”

Section: Global Epidemiology Of Admentioning

confidence: 99%

The Epidemiology and Global Burden of Atopic Dermatitis: A Narrative Review

Hadi

Tarmizi

Khalid

et al. 2021

Life

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The global epidemiology of atopic dermatitis (AD) in the current decade (2009–2019) has not been extensively reported. Epidemiological studies play an important role in presenting the risk factors of AD, as detailed prevalence and incidence data could demonstrate the burden of disease in the population of adults, adolescents, and children in different geographical regions. Thus, the primary objective of this review was to assess and summarize the epidemiological studies of the prevalence and incidence of AD in different age groups, focusing on data from studies published for 2009 to 2019. After a thorough literature search, six countries were identified from African, Asian, and European regions respectively, who published studies on AD. In contrast, only two studies were identified from Australia and New Zealand, three countries from North America and two from South America published AD studies, respectively. The highest prevalence of AD from included studies was noted among Swedish children with 34%, while the lowest prevalence was in Tunisian children with 0.65%; studies reporting incidence data were far less numerous. A common trend in the prevalence of AD was that children would have a higher prevalence as compared to adolescents and adults. The severity and morbidity of the disease showed variance with age, sex, socioeconomic characteristics, geographical location, and ethnicity. Environmental factors played an important role as causative agents in AD. The risk factors that were proven to cause and induce AD were skin barrier impairments due to FLG mutation, changes in the environment, and diet. FLG mutation may impair the skin barrier function by disruption of pH and hydration maintenance of the skin. Lastly, there were only a few studies on the incidence of AD in the 21st century. Therefore, epidemiological studies on childhood and adulthood AD in different continents are still needed, especially on the incidence of AD during adulthood.

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The prevalence and risk factors of atopic dermatitis in 6–8 year-old first graders in Taipei

Cited by 13 publications

References 30 publications

Factors Associated with Atopic Dermatitis and Allergic Rhinitis among Residents of Two Municipal Areas in South Korea

Factors Associated with Atopic Dermatitis and Allergic Rhinitis among Residents of Two Municipal Areas in South Korea

Allergen-specific immunoglobulin E and interleukin 33 in atopic dermatitis

The Epidemiology and Global Burden of Atopic Dermatitis: A Narrative Review

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