The prevalence of allergic and non-allergic bronchial asthma and the spectrum of sensitization among children of preschool age living in urban areas of the Altai Territory: a momentary population study

Шахова, Н. В.; Камалтынова, Е. М.; Lobanov, Yu.F.; Кашинская, Т. С.

doi:10.21508/1027-4065-2019-64-1-88-93

Cited by 5 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В Дагестане 50,2% больных бронхиальной астмой имеют сенсибилизацию к Der.p. В Алтайском крае у детей дошкольного возраста с бронхиальной астмой сенсибилизация к Der.p составляет 42,9% [4,5]. Среди пациентов Башкирии с аллергическими ринитами 41,3% сенсибилизированы к Der.f [6].…”

Section: Introductionunclassified

Study of the specific activity of the granulated form of the mixed-allergen from house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farinae for oral immunotherapy

Berzhets¹,

Koreneva²,

Khlgatian³

et al. 2019

Immunopathol Allergol Infectol

View full text Add to dashboard Cite

Цель. Изучить свойства гранулированной формы миксталлергена из Dermatophagoides pteronyssinus (Der.p.) и Dermatophagoides farinae (Der.f.). Методы. Для определения наличия аллергенов в экспериментальном препарате был использован микроточечный иммуноблот. Для изучения иммуногенных свойств экспериментального аллергена (ЭА) проводилась иммунизация морских свинок с последующим изучением сывороток крови животных методом ИФА. Результаты. Доказано, что гранулированная форма микст-аллергена из клещей Der.p. и Der.f. обладает аллергенспецифической активностью. ЭА вызывает статистически достоверный прирост специфических к Der.p. и Der.f. IgG антител у иммунизированных морских свинок по сравнению с контрольной группой. Выводы. Полученные результаты свидетельствуют о возможности применения препарата для иммунотерапии. Ключевые слова Гранулированная форма аллергена, клещи домашней пыли, Dermatophagoides pteronyssinus, Dermatophagoides farinaе, сублингвальная иммунотерапия Summary Objective: To study the properties of the granulated form of the mixed-allergen from Dermatophagoides pteronyssinus (Der.p.) and Dermatophagoides farinae (Der.f.). Methods: Immunodot was used for determination of allergens in the experimental preparation. Guinea pigs were immunized to study the immunogenic properties of the experimental allergen (ЕА), this was followed by the study of animal blood serum by ELISA. Results: It has been proved, that the granulated form of the mixed-allergen from Der.p. and Der.f. has an allergen specific activity. The ЕА causes a statistically significant increase of specific IgG antibodies to Der.p. and Der.f. among immunized Guinea pigs compared to the control group. Conclusion: The results indicate possible therapeutic efficacy of the ЕА in sublingual immunotherapy.

show abstract

Section: Introductionunclassified

Study of the specific activity of the granulated form of the mixed-allergen from house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farinae for oral immunotherapy

Berzhets¹,

Koreneva²,

Khlgatian³

et al. 2019

Immunopathol Allergol Infectol

View full text Add to dashboard Cite

show abstract

Clinical and Epidemiological Features of Allergies in Schoolchildren of the Chechen Republic: Results of an Epidemiological Study

Ibisheva¹,

Shamsadova²,

Namazova-Baranova

2022

Pediatr. farmakol.

View full text Add to dashboard Cite

Background. One of the topical issues of modern medicine is the widespread increase in the incidence of allergic pathology. Objective. The aim of the study is to investigate clinical and epidemiological features of allergies in schoolchildren of the Chechen Republic. Methods. We performed clinical and diagnostic verification of allergies according to clinical guidelines in patients who positively answered the ISAAC questionnaire (n = 80) — 46 first-grade and 34 eighth-grade pupils. The first diagnostic step on studying the clinical manifestations in observed children was the history taking, complaints, physical examination. Laboratory and instrumental diagnosis included: IgE total, detection of skin sensitivity to allergens via standard pollen, domestic, epidermal, and food allergens (produced by I.M. Mechnikov Research Institute of Vaccines and Sera, Stavropol Research Institute of Vaccines and Sera), revealing of allergen-specific antibodies, component-divided allergen diagnosis via indirect immunofluorescence with ImmunoCAP analyzer, respiratory function evaluation with CareFusion, nitric oxide level detection in exhaled air via portable NObreath analyzer. If needed, specialised medical consultation were performed. Results. Asthma was detected in 37 (46.3%) children, allergic rhinitis (AR) — in 37 (46.3%), atopic dermatitis (AD) — in 5 (6.3%) according to the results of our study. The most common combination of medical conditions in examined patients was combination of asthma and AR. There were no statistically significant differences in age groups. No gender differences were reported in the study. The highest incidence of asthma and AR was revealed in city residents (p < 0.05), while the AD incidence in the city and rural areas did not differ significantly. The sensibilization spectrum analysis in schoolchildren of the Chechen Republic revealed predominance of sensitivity to pollen (ragweed, herd grass) and domestic allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae). No significant differences in food sensibilization were observed. Sensibilization to epidermal allergens was also less common, the predominant one was the cat allergen. Conclusion. Thus, the first study on the territory of the Chechen Republic carried out according to the ISAAC program has revealed high prevalence of allergies in schoolchildren. Moreover, regional features of sensibilization structure have been identified. It will allow us to maintain economically optimal diagnosis of allergic diseases in children living in the Chechen Republic.

show abstract

Evaluation of the spectrum of sensitization in children with bronchial asthma in Moscow and Moscow region

Kolosova,

Denisova,

Denisova

2024

Medicinskij sovet

View full text Add to dashboard Cite

Introduction. Chronic allergic respiratory inflammation triggered by contact with cause-significant allergens is the pathogenetic characteristic of atopic bronchial asthma. Identification of sensitization is essential for successful therapy of bronchial asthma.Aim. To study age-related changes in the spectrum of sensitization to allergens in children with bronchial asthma followed up in healthcare facilities of Moscow and Moscow region.Materials and methods. A total of 970 children aged 0 to 17 years 11 months residing in Moscow and Moscow region were include in the retrospective, cross-sectional, population-based study of the spectrum of allergic sensitization of bronchial asthma based on their medical records.Results. Total IgE was only assessed in 37.11% (n = 360) of patients from the study cohort of children with bronchial asthma, of which an elevated IgE level was identified in 81% of cases (292 children), suggesting the prevalence of the atopic bronchial asthma phenotype over non-atopic asthma phenotype. The analysis showed the changing patterns of allergen sensitization by age group. Most of the patients, irrespective of their age, showed sensitization to household allergens. In addition to household allergen sensitization, food sensitization was also reported in 36% in children under 4 years of age, which was the highest rate as compared to other age periods. Sensitization to household and pollen allergens was found to increase significantly as children age (p < 0.05). Cross-sensitization (to pollens produced from wind-pollinated plants) to food allergens was low, but increased from an early age up to 15-18 years. Allergic rhinitis (AR) is a very common comorbidity of asthma and accounts for 18% with a gradual increase in indicators by the age of 18. Children with concurrent asthma have almost the same incidence of developing atopic dermatitis up to age 18.Conclusions. The prevalence of sensitization to food allergens has been established in children with asthma residing in Moscow and Moscow region under 4 years old, and the prevalence of sensitization to household, pollen and epidermal allergens — over 5 years old, which should be taken into account when managing these patients.

show abstract

The prevalence of allergic and non-allergic bronchial asthma and the spectrum of sensitization among children of preschool age living in urban areas of the Altai Territory: a momentary population study

Cited by 5 publications

References 14 publications

Study of the specific activity of the granulated form of the mixed-allergen from house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farinae for oral immunotherapy

Study of the specific activity of the granulated form of the mixed-allergen from house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farinae for oral immunotherapy

Clinical and Epidemiological Features of Allergies in Schoolchildren of the Chechen Republic: Results of an Epidemiological Study

Evaluation of the spectrum of sensitization in children with bronchial asthma in Moscow and Moscow region

Contact Info

Product

Resources

About