The Prevalence of Cleft Lip and/or Palate in Children from Łódź in Years 2001-2010

Antoszewski, Bogusław; Fijałkowska, Marta

doi:10.2478/pjs-2013-0049

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…The pattern of orofacial clefts in our study was similar to observations reported from Sudan and Europe (Jensen et al, 1988;Suleiman et al, 2005). In contrast, the isolated cleft palate was the most common pattern in some European countries (Antoszewski and Fijalkowska, 2013). These variations might be attributed to ethnic and environmental factors in the etiology of CL/P (Antoszewski and Fijalkowska, 2013).…”

supporting

confidence: 90%

Prevalence and Clinical Case Series of Syndromic and Nonsyndromic Cleft Lip and Palate in a Saudi Arabian Neonatal Population

Alyami

Ali-Hassan

Braimah³

et al. 2020

The Cleft Palate Craniofacial Journal

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Objective: To report clinical case series of cleft lip with or without palate (CL/P) and to estimate the prevalence of infants with CL/P who were syndromic or nonsyndromic. Design: This is a clinical case series study of CL/P among live births in the maternity hospital. Setting: The study was carried out in Maternity and Children Hospital, Najran between January 2013 and December 2016. Materials and Methods: Sex and clinical presentation of CL/P were collected from the medical records of live births. Clinical presentations were identified by type of CL/P and stratified according to laterality of occurrence. The data were analyzed using (SPSS) program, version 20. Results were presented in simple descriptive statistics. Main Outcome: Prevalence of CL/P in the Najran region of Saudi Arabia was 0.65 per 1000 live births (95% CI: 0.650 [0.389-1.092]). Cleft lip and palate was the commonest clinical presentation. Result: Of 24 367 live birth, 16 were classified as having CL/P. The overall frequency of CL/P was 0.65/1000 live births (95% CI: 0.650 [0.389-1.092]). There were 10 males and 5 females. Infant sex cannot be established in 1 case. Two (12.5%) patients had cleft lip, 4 (25%) had isolated cleft palate, and 10 (62.5%) had combined CL/P. Nine (56.25%) neonates were cases of nonsyndromic CL/P, while 7 (43.75%) were cases of syndromic CL/P. Conclusions: Prevalence rate of 0.65 per 1000 live births over 4-year period was observed at (95% CI: 0.650 [0.389-1.092]). Cleft lip with or without palate was the commonest clinical presentation.

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supporting

confidence: 90%

Prevalence and Clinical Case Series of Syndromic and Nonsyndromic Cleft Lip and Palate in a Saudi Arabian Neonatal Population

Alyami

Ali-Hassan

Braimah³

et al. 2020

The Cleft Palate Craniofacial Journal

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“…Orofaziale Spaltbildungen zählen zu den am weitesten verbreiteten Fehlbildungen insgesamt und entstehen aus fehlerhaften Verschmelzungsprozessen des Gesichts während der Embryogenese [17][18][19]. Es sind die häufigsten Fehlbildungen des Kopf-und Halsbereiches [20,21].…”

Section: Hintergrundunclassified

“…Zwischen den 16 Bundesländern zeigen sich keine erheblichen Unterschiede im Auftreten der 4 zusammengefassten Fehlbildungen. Auffallend sind jedoch die vergleichsweise niedrige Prävalenz in Berlin (9,41/10 000 LB, KI 8,4-10,5) und das scheinbar gehäufte Auftreten von angeborenen Fehlbildungen in Mecklenburg-Vorpommern (17,41/10 000 LB, KI 15,[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]6). Ursache dafür ist wahrscheinlich der Fehler der kleinen Zahlen, also eine Verfälschung des Ergebnisses aufgrund einer geringen Gesamtmenge.…”

Section: Ergebnisseunclassified

“…Das geringste Auftreten von kongenitalen Malformationen wurde in Berlin (9,41/10 000 LB, KI 8,4-10,5) registriert. Das höchste Auftreten (17,41/10 000 LB,KI 15,[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]6) zeigte sich in Mecklenburg-Vorpommern.DiskussionBei den gemeldeten Fällen von Omphalozele, Gastroschisis und orofazialen Spaltbildungen beobachteten wir in Deutschland einen statistisch signifikanten Anstieg über den betrachteten Zeitraum, dessen Effektgröße jedoch sehr gering ist (z. B. Omphalozele OR 1,04, KI 1,02-1,05, p-korrigiert < 0,05) und vielmehr auf die hohe ▶Abb.…”

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Prävalenz von Gastroschisis, Omphalozele, Spina bifida und orofazialen Spaltbildungen bei Neugeborenen im Zeitraum Januar 2000–Dezember 2010 in Leipzig, Sachsen, Sachsen-Anhalt und Deutschland

et al. 2016

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Whether or not there has been an actual increase in the prevalence of neonatal malformations in Germany over the years or the apparent increase is just due to bias, coding errors, multiple reporting and/or false registration and codification remains unclear. Importantly, in Germany, since prevalence of malformations is monitored prospectively only in Saxony-Anhalt and Rhineland-Palatinate, only in these states is it possible to recognize recent changes. For early identification of changes in prevalence and timely implementation of preventive measures, a nationwide register or additional regional registers are deemed necessary.

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“…Prevalence data for OFCs are often presented for CL and CLP combined (i.e., cleft lip with or without cleft palate [CL/P]) and for CP alone. Based on worldwide population-based surveillance data, the overall prevalence (per 10,000 live births) of OFCs ranges from 11.1 to 20.4 [66,[102][103][104][105][106]; the prevalence of CL/P and CP ranges from 8.9 to 13.2 and 4.0 to 7.7, respectively [63,66,102,105,[107][108][109]. Studies of the prevalence of CL have reported estimates from 3.9 to 5.0 [108][109][110].…”

Section: Orofacial Cleftsmentioning

confidence: 99%

Associations between cough medications containing dextromethorphan or guaifenesin and major structural birth defects

Cao¹

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Dextromethorphan and guaifenesin are the main active components in over-thecounter cough medications. Prenatal exposure to dextromethorphan has been shown to be teratogenic in animal models. Data from human studies for either dextromethorphan or guaifenesin are limited and inconclusive. We used data from the population-based National Birth Defects Prevention Study (NBDPS) to examine associations between maternal periconceptional (one month before through three months after conception) use of cough medications containing dextromethorphan, with or without guaifenesin, and isolated neural tube defects (NTDs). We also used NBDPS data to explore associations between such exposures and other isolated major birth defects, as well as associations between maternal periconceptional use of cough medications containing guaifenesin alone and isolated major birth defects. Enrolled cases comprised 19,538 live births, still births, and elective terminations with isolated major birth defects, and enrolled controls comprised 10,200 live births without defects delivered from October 1997 through December 2009. Telephone interview reports of pregnancy exposures, including periconceptional use of cough medications, were obtained from mothers of case and control infants. Two approaches were used to build multivariable models: backward model selection and comparing the change in odds ratios (ORs) by adding each covariable individually into the main effect models. Adjusted ORs (aORs) and 95% confidence intervals (CIs) for maternal periconceptional exposure of cough medications containing dextromethorphan, with or without guaifenesin, or guaifenesin alone, respectively, and 22 types of birth defects were estimated using multivariable logistic iv regression analysis. Applying our first multivariable model building approach, we observed that maternal periconceptional use of dextromethorphan, with or without guaifenesin, was marginally significantly associated with an increased risk of all NTDs combined (aOR=1.7, 95%CI=1.0-2.9), or spina bifida alone (aOR=1.9, 95%CI=1.0-3.5). Applying our second model-building approach confirmed the associations with all NTDs combined and spina bifida alone (aOR==1.9, 95% CI=1.2-3.0 and aOR=2.1, 95% CI=1.2-3.8; respectively). For other isolated birth defects, a positive, marginally significant association was observed for maternal periconceptional use of dextromethorphan, with or without guaifenesin, and cleft lip with or without cleft palate (aOR=1.3, 95%CI=1.0-1.7) applying our first model building approach. Our second model-building approach produced significant associations between such exposure and gastroschisis (aOR=1.8, 95%CI=1.2-2.8). With regard to maternal periconceptional use of cough medications containing guaifenesin alone, we observed marginally significant associations with all NTDs combined (aOR=1.9, 95%CI=1.1-3.5), spina bifida alone (aOR=2.3, 95%CI=1.1-4.4), or anorectal atresia (aOR=1.9, 95%CI=1.0-3.6) applying our first model-building approach. Applying our second model-building approach...

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The Prevalence of Cleft Lip and/or Palate in Children from Łódź in Years 2001-2010

Cited by 5 publications

References 5 publications

Prevalence and Clinical Case Series of Syndromic and Nonsyndromic Cleft Lip and Palate in a Saudi Arabian Neonatal Population

Prevalence and Clinical Case Series of Syndromic and Nonsyndromic Cleft Lip and Palate in a Saudi Arabian Neonatal Population

Prävalenz von Gastroschisis, Omphalozele, Spina bifida und orofazialen Spaltbildungen bei Neugeborenen im Zeitraum Januar 2000–Dezember 2010 in Leipzig, Sachsen, Sachsen-Anhalt und Deutschland

Associations between cough medications containing dextromethorphan or guaifenesin and major structural birth defects

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