The prevalence of coeliac disease is significantly higher in children compared with adults

Mariné, Meritxell; Farré, Carme; Alsina, Montserrat; Vilar, Pere; Cortijo, Montserrat; Salas, Antonio; Fernández‐Bañares, Fernando; Rosinach, Mercé; Santaolalla, Rebeca; Loras, Carme; Marques, Teresa Sá; Cusí, V.; Hernández, María Isabel; Carrasco, Anna; Ribes, Josepa; Viver, Josep Maria; Esteve, María

doi:10.1111/j.1365-2036.2010.04543.x

Cited by 72 publications

(60 citation statements)

References 39 publications

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“…The ratio of males to females (1:1.9) in our CD group was slightly lower than those reported in paediatric populations in other studies, 1:2.7 in Spain, [17] and 1:2.5 in Auckland, New Zealand. [18] However it was higher than the ratio of 1:1.4 found in a previous local study by Cook et al [4] that included a small sub-group of children under 19 years old.…”

Section: Discussioncontrasting

confidence: 47%

A Retrospective Application of the European Society for Paediatric Gastroenterology Hepatology and Nutrition Guidelines for Diagnosis of Coeliac Disease in New Zealand Children

Miller

Day²

2016

IJCD

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In 2012 the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) published an updated guideline for the diagnosis of Coeliac disease, allowing symptomatic individuals with appropriate serology and HLA genotype to be diagnosed without a small bowel biopsy. This retrospective study aimed to assess the applicability of this guideline to children in New Zealand. Children less than 16 years of age investigated for coeliac disease with small bowel biopsy in Christchurch Hospital between January 2010 and December 2012 were identified. The results of those with tissue transglutaminase IgA (tTG) levels greater than 50 units (10 times upper limit of normal), positive endomysial antibodies and HLA DQ2/DQ8 were used to calculate sensitivity and specificity. Data from 160 children was available: 70 had biopsy-confirmed Coeliac disease, and 90 had negative biopsies. Limited data precluded application of the guidelines to all patients. Using only tTG data, levels above 50 units provided a sensitivity of 67% and a specificity of 92%. Specificity increased to 97% when limited EMA and HLA DQ2/DQ8 data was added. Despite limited data, applying the ESPGHAN guidelines in the Christchurch paediatric population over this period produced a high specificity (97%). Prospective studies are now required to confirm these findings.

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Section: Discussioncontrasting

confidence: 47%

A Retrospective Application of the European Society for Paediatric Gastroenterology Hepatology and Nutrition Guidelines for Diagnosis of Coeliac Disease in New Zealand Children

Miller

Day²

2016

IJCD

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“…Comparable data on CD prevalence in children and in adults only exists for the Irkutsk region, where a higher CD prevalence was reported in children than in adults (Table 3) [34]. Environmental factors influencing infancy or CD latency in adulthood can explain this fact [35]. …”

Section: Discussionmentioning

confidence: 99%

Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence

Savvateeva

Erdes

Antishin

et al. 2017

Journal of Immunology Research

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Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of dietary gluten from some cereals mainly in individuals carrying the HLA-DQ2 and/or HLA-DQ8 haplotypes. As an autoimmune disease, CD is manifested in the small intestine in the form of a progressive and reversible inflammatory lesion due to immune response to self-antigens. Indeed, CD is one of the most challenging medicosocial problems in current gastroenterology. At present, the global CD prevalence is estimated at approximately 1% based on data sent from different locations and available CD screening strategies used. However, it is impossible to estimate global CD prevalence without all the data from the world, including Russia. In this review, we summarize the data on the incidence and prevalence of CD across geographically distinct regions of Russia, which are mostly present in local Russian scientific sources. Our conclusion is that the situation of CD prevalence in Russia is higher than is commonly believed and follows global tendencies that correspond to the epidemiologic situation in Europe, America, and Southwest Asia.

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“…A value of anti-TG2<2 U/mL was established as the cut-off limit for normality [29]. Serum IgA anti-endomisial antibodies (EmA) were examined, as previously described, [30] in patients with anti-TG2 values ranging from 2 to 8 U/mL in order to confirm their positivity.…”

Section: Methodsmentioning

confidence: 99%

Intestinal Intraepithelial Lymphocyte Cytometric Pattern Is More Accurate than Subepithelial Deposits of Anti-Tissue Transglutaminase IgA for the Diagnosis of Celiac Disease in Lymphocytic Enteritis

et al. 2014

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Background & AimsAn increase in CD3+TCRγδ+ and a decrease in CD3− intraepithelial lymphocytes (IEL) is a characteristic flow cytometric pattern of celiac disease (CD) with atrophy. The aim was to evaluate the usefulness of both CD IEL cytometric pattern and anti-TG2 IgA subepithelial deposit analysis (CD IF pattern) for diagnosing lymphocytic enteritis due to CD.MethodsTwo-hundred and five patients (144 females) who underwent duodenal biopsy for clinical suspicion of CD and positive celiac genetics were prospectively included. Fifty had villous atrophy, 70 lymphocytic enteritis, and 85 normal histology. Eight patients with non-celiac atrophy and 15 with lymphocytic enteritis secondary to Helicobacter pylori acted as control group. Duodenal biopsies were obtained to assess both CD IEL flow cytometric (complete or incomplete) and IF patterns.ResultsSensitivity of IF, and complete and incomplete cytometric patterns for CD diagnosis in patients with positive serology (Marsh 1+3) was 92%, 85 and 97% respectively, but only the complete cytometric pattern had 100% specificity. Twelve seropositive and 8 seronegative Marsh 1 patients had a CD diagnosis at inclusion or after gluten free-diet, respectively. CD cytometric pattern showed a better diagnostic performance than both IF pattern and serology for CD diagnosis in lymphocytic enteritis at baseline (95% vs 60% vs 60%, p = 0.039).ConclusionsAnalysis of the IEL flow cytometric pattern is a fast, accurate method for identifying CD in the initial diagnostic biopsy of patients presenting with lymphocytic enteritis, even in seronegative patients, and seems to be better than anti-TG2 intestinal deposits.

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The prevalence of coeliac disease is significantly higher in children compared with adults

Abstract: SUMMARY BackgroundSome limited studies of coeliac disease have shown higher frequency of coeliac disease in infancy and adolescence than in adulthood. This finding has remained unnoticed and not adequately demonstrated.

Cited by 72 publications

References 39 publications

A Retrospective Application of the European Society for Paediatric Gastroenterology Hepatology and Nutrition Guidelines for Diagnosis of Coeliac Disease in New Zealand Children

A Retrospective Application of the European Society for Paediatric Gastroenterology Hepatology and Nutrition Guidelines for Diagnosis of Coeliac Disease in New Zealand Children

Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence

Intestinal Intraepithelial Lymphocyte Cytometric Pattern Is More Accurate than Subepithelial Deposits of Anti-Tissue Transglutaminase IgA for the Diagnosis of Celiac Disease in Lymphocytic Enteritis

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